Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones
Abstract In this study, a novel hybrid nanostructure consisting of acid-decorated chitosan and magnetic AlFeO3 nanoparticles was fabricated. The acid-decorated chitosan provided a stable and biocompatible matrix for the magnetic AlFeO3 nanoparticles. Various techniques including Fourier transform in...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87779-x |
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| author | Maryam Saberi-Zare Mohammad Ali Bodaghifard |
| author_facet | Maryam Saberi-Zare Mohammad Ali Bodaghifard |
| author_sort | Maryam Saberi-Zare |
| collection | DOAJ |
| description | Abstract In this study, a novel hybrid nanostructure consisting of acid-decorated chitosan and magnetic AlFeO3 nanoparticles was fabricated. The acid-decorated chitosan provided a stable and biocompatible matrix for the magnetic AlFeO3 nanoparticles. Various techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), specific surface area (BET), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) were used to characterize and confirm the successful synthesis of the hybrid nanostructure. The newly prepared magnetic bio-nanocomposite (AlFeO3@CS-SO3H) was effectively employed in the synthesis of biologically active 7-aryl[4,3d]pyrido[1,2a]pyrimidin-6(7H)one derivatives in an aqueous medium, creating an environmentally friendly process. The desired products were manufactured in high yields (88–98%) without the formation of noticeable side products. This procedure offers numerous advantages, including short reaction times, the use of a green solvent, the ability to reuse the catalyst without a significant decrease in catalytic activity, and easy separation of the catalyst using an external magnet. The high yields and minimal side product formation indicate the efficiency and selectivity of this method, making it a promising strategy for the sustainable production of biologically active compounds. |
| format | Article |
| id | doaj-art-7215e4341de2421f80726c100e791cc5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-7215e4341de2421f80726c100e791cc52025-02-02T12:16:08ZengNature PortfolioScientific Reports2045-23222025-01-0115111610.1038/s41598-025-87779-xAcid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑onesMaryam Saberi-Zare0Mohammad Ali Bodaghifard1Department of Chemistry, Faculty of Science, Arak UniversityDepartment of Chemistry, Faculty of Science, Arak UniversityAbstract In this study, a novel hybrid nanostructure consisting of acid-decorated chitosan and magnetic AlFeO3 nanoparticles was fabricated. The acid-decorated chitosan provided a stable and biocompatible matrix for the magnetic AlFeO3 nanoparticles. Various techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), specific surface area (BET), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) were used to characterize and confirm the successful synthesis of the hybrid nanostructure. The newly prepared magnetic bio-nanocomposite (AlFeO3@CS-SO3H) was effectively employed in the synthesis of biologically active 7-aryl[4,3d]pyrido[1,2a]pyrimidin-6(7H)one derivatives in an aqueous medium, creating an environmentally friendly process. The desired products were manufactured in high yields (88–98%) without the formation of noticeable side products. This procedure offers numerous advantages, including short reaction times, the use of a green solvent, the ability to reuse the catalyst without a significant decrease in catalytic activity, and easy separation of the catalyst using an external magnet. The high yields and minimal side product formation indicate the efficiency and selectivity of this method, making it a promising strategy for the sustainable production of biologically active compounds.https://doi.org/10.1038/s41598-025-87779-xHybrid nanostructuresHeterogeneous catalysisMulticomponent reactionGreen synthesis |
| spellingShingle | Maryam Saberi-Zare Mohammad Ali Bodaghifard Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones Scientific Reports Hybrid nanostructures Heterogeneous catalysis Multicomponent reaction Green synthesis |
| title | Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones |
| title_full | Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones |
| title_fullStr | Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones |
| title_full_unstemmed | Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones |
| title_short | Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones |
| title_sort | acid decorated chitosan magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active 4 3 d pyrido 1 2 a pyrimidin 6 ones |
| topic | Hybrid nanostructures Heterogeneous catalysis Multicomponent reaction Green synthesis |
| url | https://doi.org/10.1038/s41598-025-87779-x |
| work_keys_str_mv | AT maryamsaberizare aciddecoratedchitosanmagneticaluminumferriteasabionanocompositecatalystforgreensynthesisofbiologicallyactive43dpyrido12apyrimidin6ones AT mohammadalibodaghifard aciddecoratedchitosanmagneticaluminumferriteasabionanocompositecatalystforgreensynthesisofbiologicallyactive43dpyrido12apyrimidin6ones |