Effects of Acitretin Treatment on Hearing in Patients with Psoriasis Vulgaris
Objective: In this study, we aimed to compare the hearing thresholds and outer hair cell functions of patients with psoriasis vulgaris (PV) with healthy individuals and to investigate the ototoxic effects of acitretin treatment (AT) in patients with PV. Materials and Methods: This study included 23...
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Istanbul University Press
2022-12-01
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| Series: | The Turkish Journal of Ear Nose and Throat |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/38C27111FC2043ADB13BBD17DB61A7E4 |
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| author | Başak Mutlu Merve Torun Topçu Ayşe Serap Karadağ Yasemin Gündüz Mahmut Tayyar Kalcıoğlu |
| author_facet | Başak Mutlu Merve Torun Topçu Ayşe Serap Karadağ Yasemin Gündüz Mahmut Tayyar Kalcıoğlu |
| author_sort | Başak Mutlu |
| collection | DOAJ |
| description | Objective: In this study, we aimed to compare the hearing thresholds and outer hair cell functions of patients with psoriasis vulgaris (PV) with healthy individuals and to investigate the ototoxic effects of acitretin treatment (AT) in patients with PV. Materials and Methods: This study included 23 patients with PV who required treatment with acitretin as well as 23 healthy individuals. Conventional and extended high-frequency pure-tone audiometry and transient-evoked otoacoustic emission tests were performed at regular intervals during the 24 weeks of acitretin treatment. Results: During the acitretin treatment for the PV group, the hearing thresholds of 4,000 Hz (right ear, p=0.004) presented a significant difference that did not have a worsening effect. The signal-to-noise ratios of TEOAE did not show a significant difference. At 24 weeks of AT, the changes in the hearing thresholds (4,000 Hz) and TEOAE signal-to-noise ratios did not indicate any worsening owing to acitretin. According to the ASHA criteria, there was no significant evidence of ototoxicity related to acitretin. According to the TUNE ototoxicity grading system, it was seen that at 24 weeks of AT, all the patients with psoriasis were scored as grade 0 (no hearing loss). Conclusion: This study showed that acitretin does not have an ototoxic effect when it is used to treat PV in the recommended treatment doses. |
| format | Article |
| id | doaj-art-721263a612b14e8bbbba29b384bfbfd3 |
| institution | Kabale University |
| issn | 2602-4837 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | The Turkish Journal of Ear Nose and Throat |
| spelling | doaj-art-721263a612b14e8bbbba29b384bfbfd32025-08-20T03:48:52ZengIstanbul University PressThe Turkish Journal of Ear Nose and Throat2602-48372022-12-013249210010.26650/Tr-ENT.2022.1207615123456Effects of Acitretin Treatment on Hearing in Patients with Psoriasis VulgarisBaşak Mutlu0https://orcid.org/0000-0002-9803-9258Merve Torun Topçu1https://orcid.org/0000-0002-0673-7818Ayşe Serap Karadağ2https://orcid.org/0000-0003-4333-8274Yasemin Gündüz3https://orcid.org/0000-0003-3812-6947Mahmut Tayyar Kalcıoğlu4https://orcid.org/0000-0002-6803-5467İstanbul Medeniyet Üniversitesi, İstanbul, Türkiyeİstanbul Medeniyet Üniversitesi, İstanbul, Türkiyeİstanbul Medeniyet Üniversitesi, İstanbul, Türkiyeİstanbul Medeniyet Üniversitesi, İstanbul, Türkiyeİstanbul Medeniyet Üniversitesi, İstanbul, TürkiyeObjective: In this study, we aimed to compare the hearing thresholds and outer hair cell functions of patients with psoriasis vulgaris (PV) with healthy individuals and to investigate the ototoxic effects of acitretin treatment (AT) in patients with PV. Materials and Methods: This study included 23 patients with PV who required treatment with acitretin as well as 23 healthy individuals. Conventional and extended high-frequency pure-tone audiometry and transient-evoked otoacoustic emission tests were performed at regular intervals during the 24 weeks of acitretin treatment. Results: During the acitretin treatment for the PV group, the hearing thresholds of 4,000 Hz (right ear, p=0.004) presented a significant difference that did not have a worsening effect. The signal-to-noise ratios of TEOAE did not show a significant difference. At 24 weeks of AT, the changes in the hearing thresholds (4,000 Hz) and TEOAE signal-to-noise ratios did not indicate any worsening owing to acitretin. According to the ASHA criteria, there was no significant evidence of ototoxicity related to acitretin. According to the TUNE ototoxicity grading system, it was seen that at 24 weeks of AT, all the patients with psoriasis were scored as grade 0 (no hearing loss). Conclusion: This study showed that acitretin does not have an ototoxic effect when it is used to treat PV in the recommended treatment doses.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/38C27111FC2043ADB13BBD17DB61A7E4acitretinhigh-frequency hearingototoxicitypsoriasis vulgaris |
| spellingShingle | Başak Mutlu Merve Torun Topçu Ayşe Serap Karadağ Yasemin Gündüz Mahmut Tayyar Kalcıoğlu Effects of Acitretin Treatment on Hearing in Patients with Psoriasis Vulgaris The Turkish Journal of Ear Nose and Throat acitretin high-frequency hearing ototoxicity psoriasis vulgaris |
| title | Effects of Acitretin Treatment on Hearing in Patients with Psoriasis Vulgaris |
| title_full | Effects of Acitretin Treatment on Hearing in Patients with Psoriasis Vulgaris |
| title_fullStr | Effects of Acitretin Treatment on Hearing in Patients with Psoriasis Vulgaris |
| title_full_unstemmed | Effects of Acitretin Treatment on Hearing in Patients with Psoriasis Vulgaris |
| title_short | Effects of Acitretin Treatment on Hearing in Patients with Psoriasis Vulgaris |
| title_sort | effects of acitretin treatment on hearing in patients with psoriasis vulgaris |
| topic | acitretin high-frequency hearing ototoxicity psoriasis vulgaris |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/38C27111FC2043ADB13BBD17DB61A7E4 |
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