Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatment
Abstract The objective of the present study was to develop a novel molybdenum disulfide/iron oxide/gold nanorods (MoS2/Fe3O4/GNR) nanocomposite (MFG) with different concentrations of AgNO3 solution (MFG1, MFG2, and MFG3) for topical doxorubicin (DOX) drug delivery. Then, these nanocomposites were sy...
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| Format: | Article |
| Language: | English |
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Springer
2024-08-01
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| Series: | Journal of Materials Science: Materials in Medicine |
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| Online Access: | https://doi.org/10.1007/s10856-024-06819-6 |
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| author | Behdad Shariati Mohammad Taghi Goodarzi Alireza Jalali Nasrin Salehi Majid Mozaffari |
| author_facet | Behdad Shariati Mohammad Taghi Goodarzi Alireza Jalali Nasrin Salehi Majid Mozaffari |
| author_sort | Behdad Shariati |
| collection | DOAJ |
| description | Abstract The objective of the present study was to develop a novel molybdenum disulfide/iron oxide/gold nanorods (MoS2/Fe3O4/GNR) nanocomposite (MFG) with different concentrations of AgNO3 solution (MFG1, MFG2, and MFG3) for topical doxorubicin (DOX) drug delivery. Then, these nanocomposites were synthesized and characterized by Fourier transform infrared (FTIR), Transmission electron microscopy (TEM), Dynamic light scattering (DLS), and Ultraviolet-visible (UV–Vis) spectroscopies to confirm their structural and optical properties. Cytotoxicity of samples on Hela cell was determined using MTT assay. Results indicated that nanocomposites possess little cytotoxicity without NIR laser irradiation. Also, the relative viabilities of Hela cells decreased when the concentration of AgNO3 solution increased in this nanocomposite. Using NIR irradiation, the relative viabilities of Hela cells decreased when the concentration of samples increased. Acridine orange/propidium iodide (PI) staining, flow cytometry were recruited to evaluate the effect of these nanocomposites on apoptosis of Hela cells. Finally, results revealed when DOX loading increased in nanocomposite, then cell viability was decreased in it. Therefore, these properties make MFG3 nanocomposite a good candidate for photothermal therapy and drug loading. Graphical Abstract |
| format | Article |
| id | doaj-art-720bd1f59dfb471fae0395dad50d2fad |
| institution | OA Journals |
| issn | 1573-4838 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-720bd1f59dfb471fae0395dad50d2fad2025-08-20T01:59:48ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382024-08-013511910.1007/s10856-024-06819-6Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatmentBehdad Shariati0Mohammad Taghi Goodarzi1Alireza Jalali2Nasrin Salehi3Majid Mozaffari4Department of Biochemistry, Shahrood Branch, Islamic Azad UniversityDepartment of Biochemistry, Shahrood Branch, Islamic Azad UniversityDepartment of Chemistry, Herbal Medicines Raw Materials Research Center, Shahrood Branch, Islamic Azad UniversityDepartment of Basic Sciences, Shahrood Branch, Islamic Azad UniversityDepartment of Chemistry, Herbal Medicines Raw Materials Research Center, Shahrood Branch, Islamic Azad UniversityAbstract The objective of the present study was to develop a novel molybdenum disulfide/iron oxide/gold nanorods (MoS2/Fe3O4/GNR) nanocomposite (MFG) with different concentrations of AgNO3 solution (MFG1, MFG2, and MFG3) for topical doxorubicin (DOX) drug delivery. Then, these nanocomposites were synthesized and characterized by Fourier transform infrared (FTIR), Transmission electron microscopy (TEM), Dynamic light scattering (DLS), and Ultraviolet-visible (UV–Vis) spectroscopies to confirm their structural and optical properties. Cytotoxicity of samples on Hela cell was determined using MTT assay. Results indicated that nanocomposites possess little cytotoxicity without NIR laser irradiation. Also, the relative viabilities of Hela cells decreased when the concentration of AgNO3 solution increased in this nanocomposite. Using NIR irradiation, the relative viabilities of Hela cells decreased when the concentration of samples increased. Acridine orange/propidium iodide (PI) staining, flow cytometry were recruited to evaluate the effect of these nanocomposites on apoptosis of Hela cells. Finally, results revealed when DOX loading increased in nanocomposite, then cell viability was decreased in it. Therefore, these properties make MFG3 nanocomposite a good candidate for photothermal therapy and drug loading. Graphical Abstracthttps://doi.org/10.1007/s10856-024-06819-6MFG nanocompositeGNRDOXPhotothermal therapyDrug delivery |
| spellingShingle | Behdad Shariati Mohammad Taghi Goodarzi Alireza Jalali Nasrin Salehi Majid Mozaffari Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatment Journal of Materials Science: Materials in Medicine MFG nanocomposite GNR DOX Photothermal therapy Drug delivery |
| title | Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatment |
| title_full | Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatment |
| title_fullStr | Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatment |
| title_full_unstemmed | Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatment |
| title_short | Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatment |
| title_sort | improvement photothermal property of mos2 fe3o4 gnr nanocomposite in cancer treatment |
| topic | MFG nanocomposite GNR DOX Photothermal therapy Drug delivery |
| url | https://doi.org/10.1007/s10856-024-06819-6 |
| work_keys_str_mv | AT behdadshariati improvementphotothermalpropertyofmos2fe3o4gnrnanocompositeincancertreatment AT mohammadtaghigoodarzi improvementphotothermalpropertyofmos2fe3o4gnrnanocompositeincancertreatment AT alirezajalali improvementphotothermalpropertyofmos2fe3o4gnrnanocompositeincancertreatment AT nasrinsalehi improvementphotothermalpropertyofmos2fe3o4gnrnanocompositeincancertreatment AT majidmozaffari improvementphotothermalpropertyofmos2fe3o4gnrnanocompositeincancertreatment |