The APOE Gene Cluster in Normal Aging
Aging is a multifaceted biological process characterized by numerous physiological and molecular alterations that profoundly impact health and susceptibility to disease. Among the genetic determinants influencing aging, the apolipoprotein E (APOE) gene cluster has emerged as a critical focus of rese...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-07-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/24/7/10.31083/JIN36401 |
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| author | Jolanta Florczak-Wyspiańska Mikołaj Hurła Damian Pikor Joanna Poszwa Izabela Korczowska-Łącka Oliwia Szymanowicz Agnieszka Pluto-Prądzyńska Ulyana Goutor Małgorzata Wiszniewska Wojciech Kozubski Jolanta Dorszewska |
| author_facet | Jolanta Florczak-Wyspiańska Mikołaj Hurła Damian Pikor Joanna Poszwa Izabela Korczowska-Łącka Oliwia Szymanowicz Agnieszka Pluto-Prądzyńska Ulyana Goutor Małgorzata Wiszniewska Wojciech Kozubski Jolanta Dorszewska |
| author_sort | Jolanta Florczak-Wyspiańska |
| collection | DOAJ |
| description | Aging is a multifaceted biological process characterized by numerous physiological and molecular alterations that profoundly impact health and susceptibility to disease. Among the genetic determinants influencing aging, the apolipoprotein E (APOE) gene cluster has emerged as a critical focus of research. This study explored the diverse roles of APOE in both normal and pathological aging, with particular emphasis on its involvement in Alzheimer’s disease (AD). We first examined the “physiological” aspects of aging, highlighting cellular and systemic adaptations that support organismal homeostasis. This was followed by an analysis of the pathophysiological deviations underlying neurodegenerative disorders, with AD as a key example. The role of APOE in normative aging was then discussed, including its contributions to lipid metabolism, synaptic plasticity, and neuroprotection—functions essential for maintaining both cerebral and systemic health. However, the pathological implications of APOE genetic variants, particularly the ε4 allele, were considered in relation to the increased risk of AD and other age-related diseases. Additionally, the APOE gene cluster, which includes adjacent regulatory and interactive genes, was examined for its potential to modulate APOE expression and function, thereby influencing the aging process. This synthesis underscores the pivotal role of the APOE gene cluster in elucidating the genetic and molecular mechanisms underlying aging and age-related diseases, providing a foundation for the development of targeted therapeutic interventions. |
| format | Article |
| id | doaj-art-720a340249c243a3a4e1419c68a6d260 |
| institution | Kabale University |
| issn | 0219-6352 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-720a340249c243a3a4e1419c68a6d2602025-08-20T04:02:13ZengIMR PressJournal of Integrative Neuroscience0219-63522025-07-012473640110.31083/JIN36401S0219-6352(25)00937-4The APOE Gene Cluster in Normal AgingJolanta Florczak-Wyspiańska0Mikołaj Hurła1Damian Pikor2Joanna Poszwa3Izabela Korczowska-Łącka4Oliwia Szymanowicz5Agnieszka Pluto-Prądzyńska6Ulyana Goutor7Małgorzata Wiszniewska8Wojciech Kozubski9Jolanta Dorszewska10Chair and Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandLaboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandLaboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandLaboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandLaboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandLaboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandDepartment of Clinical Immunology, Poznan University of Medical Sciences, 60-355 Poznan, PolandLaboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandFaculty of Health Care, Stanislaw Staszic University of Applied Sciences in Pila, 64-920 Pila, PolandChair and Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandLaboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, PolandAging is a multifaceted biological process characterized by numerous physiological and molecular alterations that profoundly impact health and susceptibility to disease. Among the genetic determinants influencing aging, the apolipoprotein E (APOE) gene cluster has emerged as a critical focus of research. This study explored the diverse roles of APOE in both normal and pathological aging, with particular emphasis on its involvement in Alzheimer’s disease (AD). We first examined the “physiological” aspects of aging, highlighting cellular and systemic adaptations that support organismal homeostasis. This was followed by an analysis of the pathophysiological deviations underlying neurodegenerative disorders, with AD as a key example. The role of APOE in normative aging was then discussed, including its contributions to lipid metabolism, synaptic plasticity, and neuroprotection—functions essential for maintaining both cerebral and systemic health. However, the pathological implications of APOE genetic variants, particularly the ε4 allele, were considered in relation to the increased risk of AD and other age-related diseases. Additionally, the APOE gene cluster, which includes adjacent regulatory and interactive genes, was examined for its potential to modulate APOE expression and function, thereby influencing the aging process. This synthesis underscores the pivotal role of the APOE gene cluster in elucidating the genetic and molecular mechanisms underlying aging and age-related diseases, providing a foundation for the development of targeted therapeutic interventions.https://www.imrpress.com/journal/JIN/24/7/10.31083/JIN36401molecular factorsapoe gene clusterneurodegenerationnormal aging |
| spellingShingle | Jolanta Florczak-Wyspiańska Mikołaj Hurła Damian Pikor Joanna Poszwa Izabela Korczowska-Łącka Oliwia Szymanowicz Agnieszka Pluto-Prądzyńska Ulyana Goutor Małgorzata Wiszniewska Wojciech Kozubski Jolanta Dorszewska The APOE Gene Cluster in Normal Aging Journal of Integrative Neuroscience molecular factors apoe gene cluster neurodegeneration normal aging |
| title | The APOE Gene Cluster in Normal Aging |
| title_full | The APOE Gene Cluster in Normal Aging |
| title_fullStr | The APOE Gene Cluster in Normal Aging |
| title_full_unstemmed | The APOE Gene Cluster in Normal Aging |
| title_short | The APOE Gene Cluster in Normal Aging |
| title_sort | apoe gene cluster in normal aging |
| topic | molecular factors apoe gene cluster neurodegeneration normal aging |
| url | https://www.imrpress.com/journal/JIN/24/7/10.31083/JIN36401 |
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