Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States
Background: Sleep is a multifaceted phenomenon influenced by both duration and quality. Various sleep disturbances have been associated with mild cognitive impairment, but the role of specific disturbances in mild cognitive impairment pathophysiology remains unclear. This study investigated the asso...
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| Format: | Article |
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SAGE Publishing
2025-02-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121251317912 |
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| author | Chan Shen Hao Wang Arthur Nguimatsa Djiotsop R. Constance Wiener Mona Pathak Sophie Mitra Patricia A Findley Usha Sambamoorthi |
| author_facet | Chan Shen Hao Wang Arthur Nguimatsa Djiotsop R. Constance Wiener Mona Pathak Sophie Mitra Patricia A Findley Usha Sambamoorthi |
| author_sort | Chan Shen |
| collection | DOAJ |
| description | Background: Sleep is a multifaceted phenomenon influenced by both duration and quality. Various sleep disturbances have been associated with mild cognitive impairment, but the role of specific disturbances in mild cognitive impairment pathophysiology remains unclear. This study investigated the associations between distinct sleep disturbances and mild cognitive impairment in adults aged 50 and older using nationally representative data. Methods: Longitudinal data from the Health and Retirement Study were analyzed to explore the association between mild cognitive impairment and three types of sleep disturbances: trouble falling asleep, trouble waking up, and waking up too early. Logistic regression models estimated unadjusted (Model 1) and adjusted associations accounting for sex, race/ethnicity, age, social determinants of health (Model 2), general health (Model 3), depression (Model 4), and pain and physical activity (Model 5). Results: The study cohort included 8877 participants aged ⩾50 years in 2018 (baseline) who were followed up in 2020. Overall, 15.4% reported trouble falling asleep, 23.2% reported trouble waking up, and 12.8% reported waking up too early and being unable to fall back asleep most of the time. Among older adults, approximately 13.1% reported experiencing mild cognitive impairment; The prevalence of mild cognitive impairment was even higher in those who experienced sleep disturbances. The unadjusted odds ratio (uOR) for experiencing trouble falling asleep most of the time was 1.69 (95% CI: 1.42–2.03), for trouble waking up most of the time was 1.31 (95% CI: 1.10–1.57), and for waking up early most of the time was 1.88 (95% CI: 1.51–2.35). However, these positive associations attenuated depending on the covariate adjustment. Conclusions: Nearly one in seven adults had mild cognitive impairment. The relationship between sleep disturbances and mild cognitive impairment has been challenging to delineate. Our findings demonstrate a positive association between sleep disturbances and mild cognitive impairment, although these associations were sensitive to covariate adjustments. These findings suggest multifaceted pathways for reducing the risk of mild cognitive impairment. |
| format | Article |
| id | doaj-art-7205ae786cd74c178083740d0c0a4d0d |
| institution | Kabale University |
| issn | 2050-3121 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj-art-7205ae786cd74c178083740d0c0a4d0d2025-02-07T06:03:57ZengSAGE PublishingSAGE Open Medicine2050-31212025-02-011310.1177/20503121251317912Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United StatesChan Shen0Hao Wang1Arthur Nguimatsa Djiotsop2R. Constance Wiener3Mona Pathak4Sophie Mitra5Patricia A Findley6Usha Sambamoorthi7Departments of Surgery and Public Health Sciences, Penn State College of Medicine, Hershey, PA, USADepartment of Emergency Medicine, JPS Health Network, Integrative Emergency Services, Fort Worth, TX, USADepartment of Pharmacotherapy, College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USADepartment of Dental Public Health and Professional Practice, West Virginia University, Morgantown, WV, USADepartment of Pharmacotherapy, College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USADepartment of Economics, Fordham University, Bronx, NY, USADean of the School of Social Work, Loyola University Chicago, Chicago, IL, USADepartment of Pharmacotherapy, College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USABackground: Sleep is a multifaceted phenomenon influenced by both duration and quality. Various sleep disturbances have been associated with mild cognitive impairment, but the role of specific disturbances in mild cognitive impairment pathophysiology remains unclear. This study investigated the associations between distinct sleep disturbances and mild cognitive impairment in adults aged 50 and older using nationally representative data. Methods: Longitudinal data from the Health and Retirement Study were analyzed to explore the association between mild cognitive impairment and three types of sleep disturbances: trouble falling asleep, trouble waking up, and waking up too early. Logistic regression models estimated unadjusted (Model 1) and adjusted associations accounting for sex, race/ethnicity, age, social determinants of health (Model 2), general health (Model 3), depression (Model 4), and pain and physical activity (Model 5). Results: The study cohort included 8877 participants aged ⩾50 years in 2018 (baseline) who were followed up in 2020. Overall, 15.4% reported trouble falling asleep, 23.2% reported trouble waking up, and 12.8% reported waking up too early and being unable to fall back asleep most of the time. Among older adults, approximately 13.1% reported experiencing mild cognitive impairment; The prevalence of mild cognitive impairment was even higher in those who experienced sleep disturbances. The unadjusted odds ratio (uOR) for experiencing trouble falling asleep most of the time was 1.69 (95% CI: 1.42–2.03), for trouble waking up most of the time was 1.31 (95% CI: 1.10–1.57), and for waking up early most of the time was 1.88 (95% CI: 1.51–2.35). However, these positive associations attenuated depending on the covariate adjustment. Conclusions: Nearly one in seven adults had mild cognitive impairment. The relationship between sleep disturbances and mild cognitive impairment has been challenging to delineate. Our findings demonstrate a positive association between sleep disturbances and mild cognitive impairment, although these associations were sensitive to covariate adjustments. These findings suggest multifaceted pathways for reducing the risk of mild cognitive impairment.https://doi.org/10.1177/20503121251317912 |
| spellingShingle | Chan Shen Hao Wang Arthur Nguimatsa Djiotsop R. Constance Wiener Mona Pathak Sophie Mitra Patricia A Findley Usha Sambamoorthi Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States SAGE Open Medicine |
| title | Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States |
| title_full | Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States |
| title_fullStr | Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States |
| title_full_unstemmed | Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States |
| title_short | Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States |
| title_sort | association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the united states |
| url | https://doi.org/10.1177/20503121251317912 |
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