Disseminated Cryptococcosis in a Non-HIV Patient in Singapore
We present a case of disseminated cryptococcosis (DC) in a 71-year-old gentleman with systemic lupus erythematosus (SLE) on long-term corticosteroids. He initially presented with right arm cellulitis in a tertiary hospital in Singapore and was subsequently diagnosed with DC involving skin, meninges,...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2019/3835701 |
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| _version_ | 1850221885798744064 |
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| author | Jonathan See Kok Choon Raymond Fong Humaira Shafi |
| author_facet | Jonathan See Kok Choon Raymond Fong Humaira Shafi |
| author_sort | Jonathan See |
| collection | DOAJ |
| description | We present a case of disseminated cryptococcosis (DC) in a 71-year-old gentleman with systemic lupus erythematosus (SLE) on long-term corticosteroids. He initially presented with right arm cellulitis in a tertiary hospital in Singapore and was subsequently diagnosed with DC involving skin, meninges, blood, and possibly pulmonary involvement. He eventually succumbed to the disease despite prolonged antifungal therapy. Through this case, we wish to highlight an atypical clinical presentation of an uncommon infection and hope to share the importance of considering DC in the differential diagnosis of nonresolving cellulitis among immunocompromised individuals. Mortality and morbidity rates for this condition remain high despite appropriate treatment. Early diagnosis and treatment are crucial for improved outcomes. More research is needed to improve the therapeutic modalities for treatment of DC and to improve the clinical outcomes for this life-threatening condition. |
| format | Article |
| id | doaj-art-72014960a5e8429ca2b7347aef492d54 |
| institution | OA Journals |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-72014960a5e8429ca2b7347aef492d542025-08-20T02:06:35ZengWileyCase Reports in Infectious Diseases2090-66252090-66332019-01-01201910.1155/2019/38357013835701Disseminated Cryptococcosis in a Non-HIV Patient in SingaporeJonathan See0Kok Choon Raymond Fong1Humaira Shafi2Department of Infectious Disease, Changi General Hospital, 2 Simei Street 3, 529889, SingaporeDepartment of Infectious Disease, Changi General Hospital, 2 Simei Street 3, 529889, SingaporeDepartment of Infectious Disease, Changi General Hospital, 2 Simei Street 3, 529889, SingaporeWe present a case of disseminated cryptococcosis (DC) in a 71-year-old gentleman with systemic lupus erythematosus (SLE) on long-term corticosteroids. He initially presented with right arm cellulitis in a tertiary hospital in Singapore and was subsequently diagnosed with DC involving skin, meninges, blood, and possibly pulmonary involvement. He eventually succumbed to the disease despite prolonged antifungal therapy. Through this case, we wish to highlight an atypical clinical presentation of an uncommon infection and hope to share the importance of considering DC in the differential diagnosis of nonresolving cellulitis among immunocompromised individuals. Mortality and morbidity rates for this condition remain high despite appropriate treatment. Early diagnosis and treatment are crucial for improved outcomes. More research is needed to improve the therapeutic modalities for treatment of DC and to improve the clinical outcomes for this life-threatening condition.http://dx.doi.org/10.1155/2019/3835701 |
| spellingShingle | Jonathan See Kok Choon Raymond Fong Humaira Shafi Disseminated Cryptococcosis in a Non-HIV Patient in Singapore Case Reports in Infectious Diseases |
| title | Disseminated Cryptococcosis in a Non-HIV Patient in Singapore |
| title_full | Disseminated Cryptococcosis in a Non-HIV Patient in Singapore |
| title_fullStr | Disseminated Cryptococcosis in a Non-HIV Patient in Singapore |
| title_full_unstemmed | Disseminated Cryptococcosis in a Non-HIV Patient in Singapore |
| title_short | Disseminated Cryptococcosis in a Non-HIV Patient in Singapore |
| title_sort | disseminated cryptococcosis in a non hiv patient in singapore |
| url | http://dx.doi.org/10.1155/2019/3835701 |
| work_keys_str_mv | AT jonathansee disseminatedcryptococcosisinanonhivpatientinsingapore AT kokchoonraymondfong disseminatedcryptococcosisinanonhivpatientinsingapore AT humairashafi disseminatedcryptococcosisinanonhivpatientinsingapore |