Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity
Our previous studies have reported that hydrogen sulfide (H2S) has ability to improve diabetes-associated cognitive dysfunction (DACD), but the exact mechanisms remain unknown. Recent research reveals that Warburg effect is associated with synaptic plasticity which plays a key role in cognition prom...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010224000877 |
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| author | Run-Qi Li Wei-Wen Zhu Cheng Li Ke-Bin Zhan Ping Zhang Fan Xiao Jia-Mei Jiang Wei Zou |
| author_facet | Run-Qi Li Wei-Wen Zhu Cheng Li Ke-Bin Zhan Ping Zhang Fan Xiao Jia-Mei Jiang Wei Zou |
| author_sort | Run-Qi Li |
| collection | DOAJ |
| description | Our previous studies have reported that hydrogen sulfide (H2S) has ability to improve diabetes-associated cognitive dysfunction (DACD), but the exact mechanisms remain unknown. Recent research reveals that Warburg effect is associated with synaptic plasticity which plays a key role in cognition promotion. Herein, the present study was aimed to demonstrate whether hippocampal Warburg effect contributes to H2S-ameliorated DACD and further explore its potential mechanism. We found that H2S promoted the hippocampal Warburg effect and inhibited the OxPhos in the hippocampus of STZ-induced diabetic rats. It also improved the hippocampal synaptic plasticity in STZ-induced diabetic rats, as evidenced by the change of microstructures and the expression of different key-enzymes. Furthermore, inhibited hippocampal Warburg effect induced by DCA markedly abolished the improvement of H2S on synaptic plasticity in the hippocampus of STZ-induced diabetic rats. DCA blocked H2S-attenuated the cognitive dysfunction in STZ-induced diabetic rats, according to the Y-maze, Novel Objective Recognition, and Morris Water Maze tests. Collectively, these findings indicated that the hippocampal Warburg effect mediates H2S-ameliorated DACD by improving hippocampal synaptic plasticity. |
| format | Article |
| id | doaj-art-720003d19a0f4e00b157377b35ce750a |
| institution | Kabale University |
| issn | 0168-0102 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-720003d19a0f4e00b157377b35ce750a2024-11-21T06:02:37ZengElsevierNeuroscience Research0168-01022024-11-012081528Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticityRun-Qi Li0Wei-Wen Zhu1Cheng Li2Ke-Bin Zhan3Ping Zhang4Fan Xiao5Jia-Mei Jiang6Wei Zou7The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, ChinaInstitute of Neuroscience, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, Emergency department, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, ChinaInstitute of Neuroscience, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, ChinaInstitute of Neuroscience, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; The First Affiliated Hospital, Institute of Neurology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; Corresponding author at: The First Affiliated Hospital, Institute of Neurology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; Corresponding author.Our previous studies have reported that hydrogen sulfide (H2S) has ability to improve diabetes-associated cognitive dysfunction (DACD), but the exact mechanisms remain unknown. Recent research reveals that Warburg effect is associated with synaptic plasticity which plays a key role in cognition promotion. Herein, the present study was aimed to demonstrate whether hippocampal Warburg effect contributes to H2S-ameliorated DACD and further explore its potential mechanism. We found that H2S promoted the hippocampal Warburg effect and inhibited the OxPhos in the hippocampus of STZ-induced diabetic rats. It also improved the hippocampal synaptic plasticity in STZ-induced diabetic rats, as evidenced by the change of microstructures and the expression of different key-enzymes. Furthermore, inhibited hippocampal Warburg effect induced by DCA markedly abolished the improvement of H2S on synaptic plasticity in the hippocampus of STZ-induced diabetic rats. DCA blocked H2S-attenuated the cognitive dysfunction in STZ-induced diabetic rats, according to the Y-maze, Novel Objective Recognition, and Morris Water Maze tests. Collectively, these findings indicated that the hippocampal Warburg effect mediates H2S-ameliorated DACD by improving hippocampal synaptic plasticity.http://www.sciencedirect.com/science/article/pii/S0168010224000877Warburg effectOxidative phosphorylationHydrogen sulfideDiabetes-associated cognitive dysfunctionSynaptic plasticity |
| spellingShingle | Run-Qi Li Wei-Wen Zhu Cheng Li Ke-Bin Zhan Ping Zhang Fan Xiao Jia-Mei Jiang Wei Zou Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity Neuroscience Research Warburg effect Oxidative phosphorylation Hydrogen sulfide Diabetes-associated cognitive dysfunction Synaptic plasticity |
| title | Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity |
| title_full | Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity |
| title_fullStr | Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity |
| title_full_unstemmed | Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity |
| title_short | Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity |
| title_sort | hippocampal warburg effect mediates hydrogen sulfide ameliorated diabetes associated cognitive dysfunction involving promotion of hippocampal synaptic plasticity |
| topic | Warburg effect Oxidative phosphorylation Hydrogen sulfide Diabetes-associated cognitive dysfunction Synaptic plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S0168010224000877 |
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