Evaluation of Salivary Interleukin 2 (IL-2) and Interleukin 12(IL-12) in Recurrent Aphthous Stomatitis
Recurrent aphthous stomatitis (RAS) is a common kind of excruciating mouth mucosal disease. Despite their high prevalence, etiopathogenesis remains unclear. This study was to investigate the concentration of Interleukin 2 (IL-2) and Interleukin 12 (IL-12) in the saliva of RAS. Eighty people were i...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad
2024-10-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3338 |
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| Summary: | Recurrent aphthous stomatitis (RAS) is a common kind of excruciating mouth mucosal disease. Despite their high prevalence, etiopathogenesis remains unclear. This study was to investigate the concentration of Interleukin 2 (IL-2) and Interleukin 12 (IL-12) in the saliva of RAS. Eighty people were involved In this study (forty RAS patients and forty healthy controls), their ages ranged (from 16 - 60) years. The sandwich enzyme-linked immune-sorbent assay was used to assess Interleukin 2 (IL-2) and Interleukin 12 (IL-12) concentrations in saliva in each group. The salivary concentrations of Interleukin 2 (IL-2) and Interleukin 12 (IL-12) was significantly higher in the patient group (159.06 ± 20.37), (331.32 ± 94.42) respectively in comparison to the control group at (p<0.05). These results indicate that saliva provides the perfect medium for the detection of pro-inflammatory markers of the oral cavity, Additionally, salivary Interleukin 2 (IL-2) and Interleukin 12 (IL-12) may play a significant role in the pathophysiology of this illness.
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| ISSN: | 1609-4042 2521-3407 |