Diagnosis and treatment of early eosinophilic fasciitis: a case report
Abstract Background Eosinophilic fasciitis is an infrequent connective tissue disorder that often delays treatment owing to misdiagnosis or omission. In advanced stages, severe skin sclerosis can lead to joint contracture and tendon retraction, which can severely affect the quality of life. Therefor...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-025-05440-7 |
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| author | Jinlu Ma Yunping Cai Han Shao Jingjing Dou Yusheng Yang Xiaoli Fan Cui Lu |
| author_facet | Jinlu Ma Yunping Cai Han Shao Jingjing Dou Yusheng Yang Xiaoli Fan Cui Lu |
| author_sort | Jinlu Ma |
| collection | DOAJ |
| description | Abstract Background Eosinophilic fasciitis is an infrequent connective tissue disorder that often delays treatment owing to misdiagnosis or omission. In advanced stages, severe skin sclerosis can lead to joint contracture and tendon retraction, which can severely affect the quality of life. Therefore, it is important to make a clear diagnosis and intervene in the early stages of the disease. Case presentation We report a case of a 52-year-old Chinese patient with marked symmetric swelling of her extremities, especially forearms and calves, sclerosis of the subcutaneous tissue, limited joint mobility, and whose serologic markers showed markedly elevated serum eosinophils at the beginning of the consultation. The diagnosis of eosinophilic fasciitis was further clarified and treated after refinement of soft tissue magnetic resonance imaging and subcutaneous tissue biopsy, and the patient responded favorably to treatment with marked improvement in cutaneous sclerosis and the quality of life. Conclusion Enhanced magnetic resonance imaging and whole-layer biopsy plays a critical role in enabling early diagnosis of eosinophilic fasciitis, while early treatment with a combination of glucocorticoids and methotrexate significantly improves the clinical symptoms of the disease. |
| format | Article |
| id | doaj-art-71f7009dc4804eab8764250b441a56f2 |
| institution | DOAJ |
| issn | 1752-1947 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-71f7009dc4804eab8764250b441a56f22025-08-20T03:05:29ZengBMCJournal of Medical Case Reports1752-19472025-07-011911610.1186/s13256-025-05440-7Diagnosis and treatment of early eosinophilic fasciitis: a case reportJinlu Ma0Yunping Cai1Han Shao2Jingjing Dou3Yusheng Yang4Xiaoli Fan5Cui Lu6Department of Rheumatology and Immunology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Rheumatology and Immunology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Chinese Traditional Medicine, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Chinese Traditional Medicine, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Pathology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Chinese Traditional Medicine, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Rheumatology and Immunology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of MedicineAbstract Background Eosinophilic fasciitis is an infrequent connective tissue disorder that often delays treatment owing to misdiagnosis or omission. In advanced stages, severe skin sclerosis can lead to joint contracture and tendon retraction, which can severely affect the quality of life. Therefore, it is important to make a clear diagnosis and intervene in the early stages of the disease. Case presentation We report a case of a 52-year-old Chinese patient with marked symmetric swelling of her extremities, especially forearms and calves, sclerosis of the subcutaneous tissue, limited joint mobility, and whose serologic markers showed markedly elevated serum eosinophils at the beginning of the consultation. The diagnosis of eosinophilic fasciitis was further clarified and treated after refinement of soft tissue magnetic resonance imaging and subcutaneous tissue biopsy, and the patient responded favorably to treatment with marked improvement in cutaneous sclerosis and the quality of life. Conclusion Enhanced magnetic resonance imaging and whole-layer biopsy plays a critical role in enabling early diagnosis of eosinophilic fasciitis, while early treatment with a combination of glucocorticoids and methotrexate significantly improves the clinical symptoms of the disease.https://doi.org/10.1186/s13256-025-05440-7Eosinophilic fasciitisClinical manifestationBiopsyDiagnosisTherapy |
| spellingShingle | Jinlu Ma Yunping Cai Han Shao Jingjing Dou Yusheng Yang Xiaoli Fan Cui Lu Diagnosis and treatment of early eosinophilic fasciitis: a case report Journal of Medical Case Reports Eosinophilic fasciitis Clinical manifestation Biopsy Diagnosis Therapy |
| title | Diagnosis and treatment of early eosinophilic fasciitis: a case report |
| title_full | Diagnosis and treatment of early eosinophilic fasciitis: a case report |
| title_fullStr | Diagnosis and treatment of early eosinophilic fasciitis: a case report |
| title_full_unstemmed | Diagnosis and treatment of early eosinophilic fasciitis: a case report |
| title_short | Diagnosis and treatment of early eosinophilic fasciitis: a case report |
| title_sort | diagnosis and treatment of early eosinophilic fasciitis a case report |
| topic | Eosinophilic fasciitis Clinical manifestation Biopsy Diagnosis Therapy |
| url | https://doi.org/10.1186/s13256-025-05440-7 |
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