Multimodal lung cancer theranostics via manganese phosphate/quercetin particle
Abstract The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient’s condition and drive-up treatment costs....
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-025-02242-9 |
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| author | Chong Qiu Fei Xia Qingchao Tu Huan Tang Yinan Liu Hongda Liu Chen Wang HaiLu Yao Linying Zhong Yuanfeng Fu Pengbo Guo Weiqi Chen Xinyu Zhou Li Zou Licheng Gan Jiawei Yan Yichong Hou Junzhe Zhang Huanhuan Pang Yuqing Meng Qiaoli Shi Guang Han Xijun Wang Jigang Wang |
| author_facet | Chong Qiu Fei Xia Qingchao Tu Huan Tang Yinan Liu Hongda Liu Chen Wang HaiLu Yao Linying Zhong Yuanfeng Fu Pengbo Guo Weiqi Chen Xinyu Zhou Li Zou Licheng Gan Jiawei Yan Yichong Hou Junzhe Zhang Huanhuan Pang Yuqing Meng Qiaoli Shi Guang Han Xijun Wang Jigang Wang |
| author_sort | Chong Qiu |
| collection | DOAJ |
| description | Abstract The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient’s condition and drive-up treatment costs. Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. Mechanistic studies indicated that QCT and Mn2+ exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis. Additionally, Mn2+ could activate the cGAS-STING signalling pathway and promote the maturation of dendritic cells and infiltration of activated T cells, thus inducing tumor immunogenic cell death (ICD). Furthermore, it exhibited effective T2-weighted MRI enhancement for tumor imaging, making them valuable for clinical diagnosis. In vitro and in vivo experiments demonstrated that AHA@MnP/QCT NPs enabled non-invasive imaging and tumor treatment, which presented a one-stone-for-two-birds strategy for combining tumor diagnosis and treatment, with broad potential for clinical application in non-small cell lung cancer therapy. Graphical Abstract |
| format | Article |
| id | doaj-art-71f15366fd4745cbbed84557d3723f8f |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-71f15366fd4745cbbed84557d3723f8f2025-02-09T12:15:52ZengBMCMolecular Cancer1476-45982025-02-0124112010.1186/s12943-025-02242-9Multimodal lung cancer theranostics via manganese phosphate/quercetin particleChong Qiu0Fei Xia1Qingchao Tu2Huan Tang3Yinan Liu4Hongda Liu5Chen Wang6HaiLu Yao7Linying Zhong8Yuanfeng Fu9Pengbo Guo10Weiqi Chen11Xinyu Zhou12Li Zou13Licheng Gan14Jiawei Yan15Yichong Hou16Junzhe Zhang17Huanhuan Pang18Yuqing Meng19Qiaoli Shi20Guang Han21Xijun Wang22Jigang Wang23State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese MedicineState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese MedicineState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical SciencesState Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan UniversityState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese MedicineState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese MedicineAbstract The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient’s condition and drive-up treatment costs. Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. Mechanistic studies indicated that QCT and Mn2+ exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis. Additionally, Mn2+ could activate the cGAS-STING signalling pathway and promote the maturation of dendritic cells and infiltration of activated T cells, thus inducing tumor immunogenic cell death (ICD). Furthermore, it exhibited effective T2-weighted MRI enhancement for tumor imaging, making them valuable for clinical diagnosis. In vitro and in vivo experiments demonstrated that AHA@MnP/QCT NPs enabled non-invasive imaging and tumor treatment, which presented a one-stone-for-two-birds strategy for combining tumor diagnosis and treatment, with broad potential for clinical application in non-small cell lung cancer therapy. Graphical Abstracthttps://doi.org/10.1186/s12943-025-02242-9Integrated diagnosis and treatmentAntitumor therapyMagnetic resonance imagingQuercetinManganese phosphate |
| spellingShingle | Chong Qiu Fei Xia Qingchao Tu Huan Tang Yinan Liu Hongda Liu Chen Wang HaiLu Yao Linying Zhong Yuanfeng Fu Pengbo Guo Weiqi Chen Xinyu Zhou Li Zou Licheng Gan Jiawei Yan Yichong Hou Junzhe Zhang Huanhuan Pang Yuqing Meng Qiaoli Shi Guang Han Xijun Wang Jigang Wang Multimodal lung cancer theranostics via manganese phosphate/quercetin particle Molecular Cancer Integrated diagnosis and treatment Antitumor therapy Magnetic resonance imaging Quercetin Manganese phosphate |
| title | Multimodal lung cancer theranostics via manganese phosphate/quercetin particle |
| title_full | Multimodal lung cancer theranostics via manganese phosphate/quercetin particle |
| title_fullStr | Multimodal lung cancer theranostics via manganese phosphate/quercetin particle |
| title_full_unstemmed | Multimodal lung cancer theranostics via manganese phosphate/quercetin particle |
| title_short | Multimodal lung cancer theranostics via manganese phosphate/quercetin particle |
| title_sort | multimodal lung cancer theranostics via manganese phosphate quercetin particle |
| topic | Integrated diagnosis and treatment Antitumor therapy Magnetic resonance imaging Quercetin Manganese phosphate |
| url | https://doi.org/10.1186/s12943-025-02242-9 |
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