A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Central India
BackgroundPregnant women and children are vulnerable to air pollution-related adverse health effects, especially those residing in low-resource and high-exposure settings like India. However, evidence regarding the effects of early-life exposure to air particulate matter (PM) on childhood growth/dev...
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Frontiers Media S.A.
2025-05-01
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| author | Tanwi Trushna Vikas Yadav Vikas Yadav Uday Kumar Mandal Vishal Diwan Vishal Diwan Rajnarayan R. Tiwari Rajnarayan R. Tiwari Rajesh Ahirwar Rajesh Ahirwar Dharma Raj Sindhuprava Rana Sindhuprava Rana Suchitra Vishwambhar Surve Sagnik Dey Sagnik Dey Yogesh Damodar Sabde Yogesh Damodar Sabde |
| author_facet | Tanwi Trushna Vikas Yadav Vikas Yadav Uday Kumar Mandal Vishal Diwan Vishal Diwan Rajnarayan R. Tiwari Rajnarayan R. Tiwari Rajesh Ahirwar Rajesh Ahirwar Dharma Raj Sindhuprava Rana Sindhuprava Rana Suchitra Vishwambhar Surve Sagnik Dey Sagnik Dey Yogesh Damodar Sabde Yogesh Damodar Sabde |
| author_sort | Tanwi Trushna |
| collection | DOAJ |
| description | BackgroundPregnant women and children are vulnerable to air pollution-related adverse health effects, especially those residing in low-resource and high-exposure settings like India. However, evidence regarding the effects of early-life exposure to air particulate matter (PM) on childhood growth/developmental trajectory is contradictory; evidence about specific constituents of PM, like heavy metals, is limited. Similarly, there are few Indian cohorts investigating PM exposure and the incidence of acute respiratory infection during infancy. This study protocol aims to fill these critical gaps in knowledge.MethodsWe aim to establish a mother–child birth cohort through the enrolment of 1,566 pregnant women residing in two urban areas of central India. Antenatally, we will collect socioeconomic, demographic, and clinical information and details of confounding variables from these pregnant women, who will then be followed up until childbirth to assess their exposure to air PM. Biomonitoring will also be conducted to evaluate heavy metal exposure. At birth, pregnancy outcomes will be noted, followed by postnatal follow-up of live-born children until the first year of life to assess their achievement of growth/development milestones and exposure to pollutants. We will also estimate the incidence of Acute Respiratory Infections (ARI) during infancy.DiscussionThis manuscript describes the protocol for an Indian mother–child air pollution birth cohort study that aims to generate comprehensive evidence regarding the adverse effects of early-life (i.e., both pre- and post-natal) exposure to air PM and its constituent heavy metals among Indian children. This study will provide an epidemiological basis for further understanding in this context. Finally, by reporting our carefully planned study methods/outcome measures, which are comparable to those of published and ongoing birth cohorts, we aim to serve as the starting point for similar cohorts in the future, which, when considered together, would generate enough evidence to facilitate context-specific policy-making and development of appropriate prevention and mitigation strategies. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-71ef24f1fb33465ca31fd6a95228cbb62025-08-20T03:47:36ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-05-011310.3389/fpubh.2025.14854171485417A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Central IndiaTanwi Trushna0Vikas Yadav1Vikas Yadav2Uday Kumar Mandal3Vishal Diwan4Vishal Diwan5Rajnarayan R. Tiwari6Rajnarayan R. Tiwari7Rajesh Ahirwar8Rajesh Ahirwar9Dharma Raj10Sindhuprava Rana11Sindhuprava Rana12Suchitra Vishwambhar Surve13Sagnik Dey14Sagnik Dey15Yogesh Damodar Sabde16Yogesh Damodar Sabde17Department of Environmental Health and Epidemiology, ICMR-National Institute for Research in Environmental Health, Bhopal, IndiaDepartment of Environmental Health and Epidemiology, ICMR-National Institute for Research in Environmental Health, Bhopal, IndiaFaculty of Medical Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, IndiaDepartment of Environmental Health and Epidemiology, ICMR-National Institute for Research in Environmental Health, Bhopal, IndiaFaculty of Medical Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, IndiaDepartment of Environmental Monitoring and Exposure Assessment (Water and Soil), National Institute for Research in Environmental Health, Bhopal, IndiaDepartment of Environmental Health and Epidemiology, ICMR-National Institute for Research in Environmental Health, Bhopal, IndiaFaculty of Medical Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, IndiaFaculty of Medical Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, IndiaDepartment of Environmental Biochemistry, ICMR-National Institute for Research in Environmental Health, Bhopal, IndiaDepartment of Biostatistics and Bioinformatics, ICMR-National Institute for Research in Environmental Health, Bhopal, IndiaFaculty of Medical Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, IndiaDepartment of Biostatistics and Bioinformatics, ICMR-National Institute for Research in Environmental Health, Bhopal, IndiaDepartment of Child Health Research, ICMR - National Institute for Research in Reproductive and Child Health, Mumbai, IndiaCentre for Atmospheric Sciences, Indian Institute of Technology (IIT-Delhi), Delhi, IndiaCentre of Excellence for Research on Clean Air, Indian Institute of Technology (IIT-Delhi), Delhi, IndiaDepartment of Environmental Health and Epidemiology, ICMR-National Institute for Research in Environmental Health, Bhopal, IndiaFaculty of Medical Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, IndiaBackgroundPregnant women and children are vulnerable to air pollution-related adverse health effects, especially those residing in low-resource and high-exposure settings like India. However, evidence regarding the effects of early-life exposure to air particulate matter (PM) on childhood growth/developmental trajectory is contradictory; evidence about specific constituents of PM, like heavy metals, is limited. Similarly, there are few Indian cohorts investigating PM exposure and the incidence of acute respiratory infection during infancy. This study protocol aims to fill these critical gaps in knowledge.MethodsWe aim to establish a mother–child birth cohort through the enrolment of 1,566 pregnant women residing in two urban areas of central India. Antenatally, we will collect socioeconomic, demographic, and clinical information and details of confounding variables from these pregnant women, who will then be followed up until childbirth to assess their exposure to air PM. Biomonitoring will also be conducted to evaluate heavy metal exposure. At birth, pregnancy outcomes will be noted, followed by postnatal follow-up of live-born children until the first year of life to assess their achievement of growth/development milestones and exposure to pollutants. We will also estimate the incidence of Acute Respiratory Infections (ARI) during infancy.DiscussionThis manuscript describes the protocol for an Indian mother–child air pollution birth cohort study that aims to generate comprehensive evidence regarding the adverse effects of early-life (i.e., both pre- and post-natal) exposure to air PM and its constituent heavy metals among Indian children. This study will provide an epidemiological basis for further understanding in this context. Finally, by reporting our carefully planned study methods/outcome measures, which are comparable to those of published and ongoing birth cohorts, we aim to serve as the starting point for similar cohorts in the future, which, when considered together, would generate enough evidence to facilitate context-specific policy-making and development of appropriate prevention and mitigation strategies.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1485417/fullacute respiratory infectionair pollutionbirth cohortchild developmentgrowthheavy metals |
| spellingShingle | Tanwi Trushna Vikas Yadav Vikas Yadav Uday Kumar Mandal Vishal Diwan Vishal Diwan Rajnarayan R. Tiwari Rajnarayan R. Tiwari Rajesh Ahirwar Rajesh Ahirwar Dharma Raj Sindhuprava Rana Sindhuprava Rana Suchitra Vishwambhar Surve Sagnik Dey Sagnik Dey Yogesh Damodar Sabde Yogesh Damodar Sabde A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Central India Frontiers in Public Health acute respiratory infection air pollution birth cohort child development growth heavy metals |
| title | A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Central India |
| title_full | A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Central India |
| title_fullStr | A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Central India |
| title_full_unstemmed | A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Central India |
| title_short | A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Central India |
| title_sort | protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition a mother child birth elite cohort from central india |
| topic | acute respiratory infection air pollution birth cohort child development growth heavy metals |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1485417/full |
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