Chemical Characterization and Biological Activity of <i>Varronia curassavica</i> Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-Pinene
Multidrug-resistant bacteria have complicated the treatment of gastrointestinal diseases; their microbial resistance stems from the indiscriminate use of medications and the transfer of resistance genes. <i>Varronia curassavica</i> Jacq., a plant traditionally used to treat rheumatic and...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Analytica |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4532/5/4/34 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850042569686253568 |
|---|---|
| author | José Thyálisson da Costa Silva Viviane Bezerra da Silva Sabrina Bezerra da Silva Maria Ivaneide Rocha Adrielle Rodrigues Costa Jailson Renato de Lima Silva Marcos Aurélio Figueirêdo dos Santos Maria Elizete Machado Generino Jeovane Henrique de Souza Maraiza Gregorio de Oliveira Clara Mariana Gonçalves Lima Raimundo Luiz Silva Pereira Renata Ferreira Santana Isaac Moura Araujo Maria Flaviana Bezerra Morais-Braga Talha Bin Emran Henrique Douglas Melo Coutinho José Weverton Almeida-Bezerra |
| author_facet | José Thyálisson da Costa Silva Viviane Bezerra da Silva Sabrina Bezerra da Silva Maria Ivaneide Rocha Adrielle Rodrigues Costa Jailson Renato de Lima Silva Marcos Aurélio Figueirêdo dos Santos Maria Elizete Machado Generino Jeovane Henrique de Souza Maraiza Gregorio de Oliveira Clara Mariana Gonçalves Lima Raimundo Luiz Silva Pereira Renata Ferreira Santana Isaac Moura Araujo Maria Flaviana Bezerra Morais-Braga Talha Bin Emran Henrique Douglas Melo Coutinho José Weverton Almeida-Bezerra |
| author_sort | José Thyálisson da Costa Silva |
| collection | DOAJ |
| description | Multidrug-resistant bacteria have complicated the treatment of gastrointestinal diseases; their microbial resistance stems from the indiscriminate use of medications and the transfer of resistance genes. <i>Varronia curassavica</i> Jacq., a plant traditionally used to treat rheumatic and gastrointestinal diseases in underserved populations, has sparked interest as a potential source of antimicrobial compounds. This study aimed to investigate the chemical composition and antibacterial effects of <i>V. curassavica</i> essential oil and to evaluate its toxicity in <i>Drosophila melanogaster</i>. The essential oil was extracted through hydrodistillation and its chemical composition was determined using GC-MS. Antibacterial tests were performed with microdilution. The results showed the presence of major compounds including α-pinene and β-caryophyllene. The essential oil did not show relevant MIC, but it enhanced the effects of the antibiotics, gentamicin, norfloxacin, and oxacillin. It exhibited no toxicity and did not affect geotaxis, even at high concentrations. The in silico analysis of α-pinene revealed low toxicity; however, its permeability to the BBB shows that caution is needed in its application. These results indicate that the essential oil of <i>V. curassavica</i> shows promising potential in enhancing pharmaceuticals to prevent increased bacterial resistance. In addition, it demonstrated safe aspects when tested on <i>D. melanogaster</i>. |
| format | Article |
| id | doaj-art-71eed2e822fd482f8d3cca7f8f00d05c |
| institution | DOAJ |
| issn | 2673-4532 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Analytica |
| spelling | doaj-art-71eed2e822fd482f8d3cca7f8f00d05c2025-08-20T02:55:31ZengMDPI AGAnalytica2673-45322024-10-015449951110.3390/analytica5040034Chemical Characterization and Biological Activity of <i>Varronia curassavica</i> Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-PineneJosé Thyálisson da Costa Silva0Viviane Bezerra da Silva1Sabrina Bezerra da Silva2Maria Ivaneide Rocha3Adrielle Rodrigues Costa4Jailson Renato de Lima Silva5Marcos Aurélio Figueirêdo dos Santos6Maria Elizete Machado Generino7Jeovane Henrique de Souza8Maraiza Gregorio de Oliveira9Clara Mariana Gonçalves Lima10Raimundo Luiz Silva Pereira11Renata Ferreira Santana12Isaac Moura Araujo13Maria Flaviana Bezerra Morais-Braga14Talha Bin Emran15Henrique Douglas Melo Coutinho16José Weverton Almeida-Bezerra17Cariri Applied Mycology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilApplied Ecology and Phytochemistry Laboratory, Federal University of Pernambuco, Recife 50740-600, PE, BrazilPlant Ecophysiology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilPlant Ecophysiology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilPlant Ecophysiology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilPlant Ecophysiology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilApplied Botany Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilApplied Botany Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilPlant Ecophysiology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilPlant Ecophysiology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato 63105-000, CE, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato 63105-000, CE, BrazilDepartment of Food Science and Engineering, Southwestern Bahia State University, Itapetinga 45083-900, BA, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato 63105-000, CE, BrazilCariri Applied Mycology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912, USALaboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato 63105-000, CE, BrazilCariri Applied Mycology Laboratory, Regional University of Cariri, Crato 63105-000, CE, BrazilMultidrug-resistant bacteria have complicated the treatment of gastrointestinal diseases; their microbial resistance stems from the indiscriminate use of medications and the transfer of resistance genes. <i>Varronia curassavica</i> Jacq., a plant traditionally used to treat rheumatic and gastrointestinal diseases in underserved populations, has sparked interest as a potential source of antimicrobial compounds. This study aimed to investigate the chemical composition and antibacterial effects of <i>V. curassavica</i> essential oil and to evaluate its toxicity in <i>Drosophila melanogaster</i>. The essential oil was extracted through hydrodistillation and its chemical composition was determined using GC-MS. Antibacterial tests were performed with microdilution. The results showed the presence of major compounds including α-pinene and β-caryophyllene. The essential oil did not show relevant MIC, but it enhanced the effects of the antibiotics, gentamicin, norfloxacin, and oxacillin. It exhibited no toxicity and did not affect geotaxis, even at high concentrations. The in silico analysis of α-pinene revealed low toxicity; however, its permeability to the BBB shows that caution is needed in its application. These results indicate that the essential oil of <i>V. curassavica</i> shows promising potential in enhancing pharmaceuticals to prevent increased bacterial resistance. In addition, it demonstrated safe aspects when tested on <i>D. melanogaster</i>.https://www.mdpi.com/2673-4532/5/4/34erva-baleeira<i>Cordia verbenacea</i>α-humulenesecondary metabolites |
| spellingShingle | José Thyálisson da Costa Silva Viviane Bezerra da Silva Sabrina Bezerra da Silva Maria Ivaneide Rocha Adrielle Rodrigues Costa Jailson Renato de Lima Silva Marcos Aurélio Figueirêdo dos Santos Maria Elizete Machado Generino Jeovane Henrique de Souza Maraiza Gregorio de Oliveira Clara Mariana Gonçalves Lima Raimundo Luiz Silva Pereira Renata Ferreira Santana Isaac Moura Araujo Maria Flaviana Bezerra Morais-Braga Talha Bin Emran Henrique Douglas Melo Coutinho José Weverton Almeida-Bezerra Chemical Characterization and Biological Activity of <i>Varronia curassavica</i> Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-Pinene Analytica erva-baleeira <i>Cordia verbenacea</i> α-humulene secondary metabolites |
| title | Chemical Characterization and Biological Activity of <i>Varronia curassavica</i> Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-Pinene |
| title_full | Chemical Characterization and Biological Activity of <i>Varronia curassavica</i> Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-Pinene |
| title_fullStr | Chemical Characterization and Biological Activity of <i>Varronia curassavica</i> Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-Pinene |
| title_full_unstemmed | Chemical Characterization and Biological Activity of <i>Varronia curassavica</i> Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-Pinene |
| title_short | Chemical Characterization and Biological Activity of <i>Varronia curassavica</i> Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-Pinene |
| title_sort | chemical characterization and biological activity of i varronia curassavica i jacq essential oil boraginaceae and in silico testing of α pinene |
| topic | erva-baleeira <i>Cordia verbenacea</i> α-humulene secondary metabolites |
| url | https://www.mdpi.com/2673-4532/5/4/34 |
| work_keys_str_mv | AT josethyalissondacostasilva chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT vivianebezerradasilva chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT sabrinabezerradasilva chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT mariaivaneiderocha chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT adriellerodriguescosta chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT jailsonrenatodelimasilva chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT marcosaureliofigueiredodossantos chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT mariaelizetemachadogenerino chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT jeovanehenriquedesouza chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT maraizagregoriodeoliveira chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT claramarianagoncalveslima chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT raimundoluizsilvapereira chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT renataferreirasantana chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT isaacmouraaraujo chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT mariaflavianabezerramoraisbraga chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT talhabinemran chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT henriquedouglasmelocoutinho chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene AT josewevertonalmeidabezerra chemicalcharacterizationandbiologicalactivityofivarroniacurassavicaijacqessentialoilboraginaceaeandinsilicotestingofapinene |