Hyper-fractionated radiotherapy as a bridging strategy to enhance CAR-T efficacy by regulating T-cell co-stimulatory molecules in relapsed/refractory diffuse large B-cell lymphoma

Hyper-fractionated radiotherapy as a bridging strategy to enhance CAR-T efficacy by regulating T-cell co-stimulatory molecules in relapsed/refractory diffuse large B-cell lymphoma

BackgroundBridging therapy can prevent patients from disease progression while waiting for CAR-T cell preparation. Hyper-fractionated radiotherapy can achieve an effective target dose within a short period, minimize radiation damage, and may modify immune environment compared to conventional radioth...

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Bibliographic Details
Main Authors: Jing Ruan, Daobin Zhou, Yan Zhang, Danqing Zhao, Chong Wei, Ke Hu, Fuquan Zhang, Xiaorong Hou, Wei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
hyper-fractionated radiotherapy
DLBCL
CAR-T
bridging therapy
T-cell co-stimulatory molecules
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481080/full
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