Single-cell RNA sequencing for the study of lupus nephritis
Single-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in many biological systems and diseases. The single-cell resolution of the technique allows for the investigation of heterogeneity...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2019-12-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/6/1/e000329.full |
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| _version_ | 1850256116437483520 |
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| author | Jill Buyon Chaim Putterman Evan Der |
| author_facet | Jill Buyon Chaim Putterman Evan Der |
| author_sort | Jill Buyon |
| collection | DOAJ |
| description | Single-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in many biological systems and diseases. The single-cell resolution of the technique allows for the investigation of heterogeneity in cell populations, and the pinpointing of pathological populations contributing to disease. Here we review the development of scRNA-seq technology and the analysis that has evolved with the ever-increasing throughput. Finally, we highlight recent applications of scRNA-seq to understand the molecular pathogenesis of lupus and lupus nephritis. |
| format | Article |
| id | doaj-art-71e4e6ff3cd142dbbc5c380544dc832f |
| institution | OA Journals |
| issn | 2053-8790 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Lupus Science and Medicine |
| spelling | doaj-art-71e4e6ff3cd142dbbc5c380544dc832f2025-08-20T01:56:42ZengBMJ Publishing GroupLupus Science and Medicine2053-87902019-12-016110.1136/lupus-2019-000329Single-cell RNA sequencing for the study of lupus nephritisJill Buyon0Chaim Putterman1Evan Der2Grossman School of Medicine, New York University, New York, New York, USA6 Research Institute, Galilee Medical Center, Nahariya, IsraelDivision of Rheumatology, Albert Einstein College of Medicine, Bronx, New York, USASingle-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in many biological systems and diseases. The single-cell resolution of the technique allows for the investigation of heterogeneity in cell populations, and the pinpointing of pathological populations contributing to disease. Here we review the development of scRNA-seq technology and the analysis that has evolved with the ever-increasing throughput. Finally, we highlight recent applications of scRNA-seq to understand the molecular pathogenesis of lupus and lupus nephritis.https://lupus.bmj.com/content/6/1/e000329.full |
| spellingShingle | Jill Buyon Chaim Putterman Evan Der Single-cell RNA sequencing for the study of lupus nephritis Lupus Science and Medicine |
| title | Single-cell RNA sequencing for the study of lupus nephritis |
| title_full | Single-cell RNA sequencing for the study of lupus nephritis |
| title_fullStr | Single-cell RNA sequencing for the study of lupus nephritis |
| title_full_unstemmed | Single-cell RNA sequencing for the study of lupus nephritis |
| title_short | Single-cell RNA sequencing for the study of lupus nephritis |
| title_sort | single cell rna sequencing for the study of lupus nephritis |
| url | https://lupus.bmj.com/content/6/1/e000329.full |
| work_keys_str_mv | AT jillbuyon singlecellrnasequencingforthestudyoflupusnephritis AT chaimputterman singlecellrnasequencingforthestudyoflupusnephritis AT evander singlecellrnasequencingforthestudyoflupusnephritis |