Selective immunoglobulin A deficiency combined with juvenile idiopathic arthritis: a report of two cases and literature review
Abstract Objective To investigate the clinical characteristics of selective immunoglobulin A deficiency (SIgAD) combined with juvenile idiopathic arthritis (JIA). Methods A retrospective analysis of the clinical data and follow-up data of children with SIgAD combined with JIA was conducted. Results...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-05-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
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| Online Access: | https://doi.org/10.1186/s43166-025-00315-7 |
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| author | Tan Yinli Buweimaieryemu Yusufu Caiju Luo Yikun Mou Yuxing Zhu Cai Yun |
| author_facet | Tan Yinli Buweimaieryemu Yusufu Caiju Luo Yikun Mou Yuxing Zhu Cai Yun |
| author_sort | Tan Yinli |
| collection | DOAJ |
| description | Abstract Objective To investigate the clinical characteristics of selective immunoglobulin A deficiency (SIgAD) combined with juvenile idiopathic arthritis (JIA). Methods A retrospective analysis of the clinical data and follow-up data of children with SIgAD combined with JIA was conducted. Results Both patients were female, patient 1 was 13 years old and of Han nationality from Guangdong Province (southern China), and patient 2 was 4 years and 10 months old and of Uygur nationality from Xinjiang Province (northwest China). The main clinical manifestations were joint deformity, joint pain, limited activity, and a serum IgA concentration < 0 g/ L. After treatment with immunosuppressants, biological agents and rehabilitation, the symptoms improved, but joint deformity and functional disability remained. Conclusion Children with SIgAD combined with JIA may experience early disease onset, multiple joint involvement, and poor curative effects. Early diagnosis, timely intervention, and combination therapy are crucial for reducing long-term sequelae and improving clinical outcomes. |
| format | Article |
| id | doaj-art-71e37be54aff4e75a632e64cb24849bb |
| institution | DOAJ |
| issn | 2090-3235 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj-art-71e37be54aff4e75a632e64cb24849bb2025-08-20T03:09:20ZengSpringerOpenEgyptian Rheumatology and Rehabilitation2090-32352025-05-0152111010.1186/s43166-025-00315-7Selective immunoglobulin A deficiency combined with juvenile idiopathic arthritis: a report of two cases and literature reviewTan Yinli0Buweimaieryemu Yusufu1Caiju Luo2Yikun Mou3Yuxing Zhu4Cai Yun5The Third Affiliated Hospital of Sun Yat-Sen UniversityThe First People’S Hospital of Kashi PrefectureSun Yat-Sen Memorial HospitalThe Third Affiliated Hospital of Sun Yat-Sen UniversityThe Third Affiliated Hospital of Sun Yat-Sen UniversityThe Third Affiliated Hospital of Sun Yat-Sen UniversityAbstract Objective To investigate the clinical characteristics of selective immunoglobulin A deficiency (SIgAD) combined with juvenile idiopathic arthritis (JIA). Methods A retrospective analysis of the clinical data and follow-up data of children with SIgAD combined with JIA was conducted. Results Both patients were female, patient 1 was 13 years old and of Han nationality from Guangdong Province (southern China), and patient 2 was 4 years and 10 months old and of Uygur nationality from Xinjiang Province (northwest China). The main clinical manifestations were joint deformity, joint pain, limited activity, and a serum IgA concentration < 0 g/ L. After treatment with immunosuppressants, biological agents and rehabilitation, the symptoms improved, but joint deformity and functional disability remained. Conclusion Children with SIgAD combined with JIA may experience early disease onset, multiple joint involvement, and poor curative effects. Early diagnosis, timely intervention, and combination therapy are crucial for reducing long-term sequelae and improving clinical outcomes.https://doi.org/10.1186/s43166-025-00315-7SIgADJIAClinical manifestationsPrognosis |
| spellingShingle | Tan Yinli Buweimaieryemu Yusufu Caiju Luo Yikun Mou Yuxing Zhu Cai Yun Selective immunoglobulin A deficiency combined with juvenile idiopathic arthritis: a report of two cases and literature review Egyptian Rheumatology and Rehabilitation SIgAD JIA Clinical manifestations Prognosis |
| title | Selective immunoglobulin A deficiency combined with juvenile idiopathic arthritis: a report of two cases and literature review |
| title_full | Selective immunoglobulin A deficiency combined with juvenile idiopathic arthritis: a report of two cases and literature review |
| title_fullStr | Selective immunoglobulin A deficiency combined with juvenile idiopathic arthritis: a report of two cases and literature review |
| title_full_unstemmed | Selective immunoglobulin A deficiency combined with juvenile idiopathic arthritis: a report of two cases and literature review |
| title_short | Selective immunoglobulin A deficiency combined with juvenile idiopathic arthritis: a report of two cases and literature review |
| title_sort | selective immunoglobulin a deficiency combined with juvenile idiopathic arthritis a report of two cases and literature review |
| topic | SIgAD JIA Clinical manifestations Prognosis |
| url | https://doi.org/10.1186/s43166-025-00315-7 |
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