The mechanism of super-enhancer regulation of gene expression and research progress in neurodegenerative diseases
Super-enhancers (SEs) play a key role in cell fate determination by regulating the transcription of cell-specific target genes and may contribute to the pathogenesis of neurodegenerative diseases. Targeted inhibition of the activity of SEs or knockout of SEs fragments may represent a novel therapeut...
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| Format: | Article |
| Language: | English |
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2025-04-01
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| Series: | Revista de Investigación Clínica |
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| Online Access: | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=527 |
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| _version_ | 1850198656439812096 |
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| author | Shaofei Zhao Qian Yang Changjun Gao |
| author_facet | Shaofei Zhao Qian Yang Changjun Gao |
| author_sort | Shaofei Zhao |
| collection | DOAJ |
| description | Super-enhancers (SEs) play a key role in cell fate determination by regulating the transcription of cell-specific target genes and may contribute to the pathogenesis of neurodegenerative diseases. Targeted inhibition of the activity of SEs or knockout of SEs fragments may represent a novel therapeutic strategy for neurodegenerative diseases. This article mainly outlines the discovery, structure, and identification methods of SEs; lists the current SE database platforms; summarizes the main regulatory mechanisms of SEs and strategies to acquire disease-specific SEs; and reviews recent research advances on SEs in neurodegenerative diseases. These findings provide new insights into the molecular mechanisms and development of treatment for neurodegenerative diseases.
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| format | Article |
| id | doaj-art-71e1f01e68734f9bae02972d6067e2ca |
| institution | OA Journals |
| issn | 0034-8376 2564-8896 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista de Investigación Clínica |
| spelling | doaj-art-71e1f01e68734f9bae02972d6067e2ca2025-08-20T02:12:49ZengPermanyerRevista de Investigación Clínica0034-83762564-88962025-04-0177210.24875/RIC.24000246The mechanism of super-enhancer regulation of gene expression and research progress in neurodegenerative diseasesShaofei Zhao0Qian Yang1Changjun Gao2Departments of Anesthesiology and Experimental Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Experimental Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Anesthesiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, ChinaSuper-enhancers (SEs) play a key role in cell fate determination by regulating the transcription of cell-specific target genes and may contribute to the pathogenesis of neurodegenerative diseases. Targeted inhibition of the activity of SEs or knockout of SEs fragments may represent a novel therapeutic strategy for neurodegenerative diseases. This article mainly outlines the discovery, structure, and identification methods of SEs; lists the current SE database platforms; summarizes the main regulatory mechanisms of SEs and strategies to acquire disease-specific SEs; and reviews recent research advances on SEs in neurodegenerative diseases. These findings provide new insights into the molecular mechanisms and development of treatment for neurodegenerative diseases. https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=527Enhancer. Super-enhancers. Alzheimer’s disease. Parkinson’s disease. Huntington’s disease. |
| spellingShingle | Shaofei Zhao Qian Yang Changjun Gao The mechanism of super-enhancer regulation of gene expression and research progress in neurodegenerative diseases Revista de Investigación Clínica Enhancer. Super-enhancers. Alzheimer’s disease. Parkinson’s disease. Huntington’s disease. |
| title | The mechanism of super-enhancer regulation of gene expression and research progress in neurodegenerative diseases |
| title_full | The mechanism of super-enhancer regulation of gene expression and research progress in neurodegenerative diseases |
| title_fullStr | The mechanism of super-enhancer regulation of gene expression and research progress in neurodegenerative diseases |
| title_full_unstemmed | The mechanism of super-enhancer regulation of gene expression and research progress in neurodegenerative diseases |
| title_short | The mechanism of super-enhancer regulation of gene expression and research progress in neurodegenerative diseases |
| title_sort | mechanism of super enhancer regulation of gene expression and research progress in neurodegenerative diseases |
| topic | Enhancer. Super-enhancers. Alzheimer’s disease. Parkinson’s disease. Huntington’s disease. |
| url | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=527 |
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