Histone modification in diabetic nephropathy
Diabetic nephropathy （DN） is a clinical syndrome characterized by persistent proteinuria and progressive decline in renal function. It is a typical glomerular disease. The incidence is rising yearly and it has become the most common cause of end-stage renal disease. It is particularly important to e...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2022-01-01
|
| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.01.015 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850039995992113152 |
|---|---|
| author | Cao Zi-yu Ma Dong-hong |
| author_facet | Cao Zi-yu Ma Dong-hong |
| author_sort | Cao Zi-yu |
| collection | DOAJ |
| description | Diabetic nephropathy （DN） is a clinical syndrome characterized by persistent proteinuria and progressive decline in renal function. It is a typical glomerular disease. The incidence is rising yearly and it has become the most common cause of end-stage renal disease. It is particularly important to elucidate the underlying pathogenesis of DN. A growing body of evidence has demonstrated that the pathogenesis of DN is not only regulated by classical signaling pathways，but also by such epigenetic mechanisms as histone modification，DNA methylation and non-coding RNA. With the continuous discovery of research，the role of histone modification in the pathogenesis of DN has come into spotlightr. This review summarized the role of histone modifications in the pathogenesis of DN and the therapeutic prospects for DN. |
| format | Article |
| id | doaj-art-71dd57c730004f6c95061e95c1a8a201 |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-71dd57c730004f6c95061e95c1a8a2012025-08-20T02:56:11ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-01-0122778123110544Histone modification in diabetic nephropathyCao Zi-yuMa Dong-hongDiabetic nephropathy （DN） is a clinical syndrome characterized by persistent proteinuria and progressive decline in renal function. It is a typical glomerular disease. The incidence is rising yearly and it has become the most common cause of end-stage renal disease. It is particularly important to elucidate the underlying pathogenesis of DN. A growing body of evidence has demonstrated that the pathogenesis of DN is not only regulated by classical signaling pathways，but also by such epigenetic mechanisms as histone modification，DNA methylation and non-coding RNA. With the continuous discovery of research，the role of histone modification in the pathogenesis of DN has come into spotlightr. This review summarized the role of histone modifications in the pathogenesis of DN and the therapeutic prospects for DN.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.01.015Diabetic nephropathyEpigeneticsHistone modification |
| spellingShingle | Cao Zi-yu Ma Dong-hong Histone modification in diabetic nephropathy Linchuang shenzangbing zazhi Diabetic nephropathy Epigenetics Histone modification |
| title | Histone modification in diabetic nephropathy |
| title_full | Histone modification in diabetic nephropathy |
| title_fullStr | Histone modification in diabetic nephropathy |
| title_full_unstemmed | Histone modification in diabetic nephropathy |
| title_short | Histone modification in diabetic nephropathy |
| title_sort | histone modification in diabetic nephropathy |
| topic | Diabetic nephropathy Epigenetics Histone modification |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.01.015 |
| work_keys_str_mv | AT caoziyu histonemodificationindiabeticnephropathy AT madonghong histonemodificationindiabeticnephropathy |