Release of tumor necrosis factor-α and prostanoids in whole blood cultures after in vivo exposure to low-dose aspirin
Background: The preventive effect of low-dose aspirin in cardiovascular disease is generally attributed to its antiplatelet action caused by differential inhibition of platelet cyclooxygenase-1. However, there is evidence that aspirin also affects release of inflammatory cytokines, including tumor n...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350120054554 |
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| _version_ | 1849414843870740480 |
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| author | Ilse Beckmann Shlomo Ben-Efraim Monica Vervoort Henk C. S. Wallenburg |
| author_facet | Ilse Beckmann Shlomo Ben-Efraim Monica Vervoort Henk C. S. Wallenburg |
| author_sort | Ilse Beckmann |
| collection | DOAJ |
| description | Background: The preventive effect of low-dose aspirin in cardiovascular disease is generally attributed to its antiplatelet action caused by differential inhibition of platelet cyclooxygenase-1. However, there is evidence that aspirin also affects release of inflammatory cytokines, including tumor necrosis factor-α (TNF-α). It is not known whether this is caused by direct action on the cytokine pathway or indirectly through cyclooxygenase inhibition and altered prostanoid synthesis, or both. |
| format | Article |
| id | doaj-art-71dce5b5d7f74367979923ef6b9a72dd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-71dce5b5d7f74367979923ef6b9a72dd2025-08-20T03:33:42ZengWileyMediators of Inflammation0962-93511466-18612001-01-01102818810.1080/09629350120054554Release of tumor necrosis factor-α and prostanoids in whole blood cultures after in vivo exposure to low-dose aspirinIlse Beckmann0Shlomo Ben-Efraim1Monica Vervoort2Henk C. S. Wallenburg3Department of Obstetrics and Gynecology, Erasmus University School of Medicine and Health Sciences, P.O.B. 1738, Rotterdam 3000 DR, The NetherlandsDepartment of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel Aviv, IsraelDepartment of Obstetrics and Gynecology, Erasmus University School of Medicine and Health Sciences, P.O.B. 1738, Rotterdam 3000 DR, The NetherlandsDepartment of Obstetrics and Gynecology, Erasmus University School of Medicine and Health Sciences, P.O.B. 1738, Rotterdam 3000 DR, The NetherlandsBackground: The preventive effect of low-dose aspirin in cardiovascular disease is generally attributed to its antiplatelet action caused by differential inhibition of platelet cyclooxygenase-1. However, there is evidence that aspirin also affects release of inflammatory cytokines, including tumor necrosis factor-α (TNF-α). It is not known whether this is caused by direct action on the cytokine pathway or indirectly through cyclooxygenase inhibition and altered prostanoid synthesis, or both.http://dx.doi.org/10.1080/09629350120054554 |
| spellingShingle | Ilse Beckmann Shlomo Ben-Efraim Monica Vervoort Henk C. S. Wallenburg Release of tumor necrosis factor-α and prostanoids in whole blood cultures after in vivo exposure to low-dose aspirin Mediators of Inflammation |
| title | Release of tumor necrosis factor-α and prostanoids in whole blood cultures after
in vivo exposure to low-dose aspirin |
| title_full | Release of tumor necrosis factor-α and prostanoids in whole blood cultures after
in vivo exposure to low-dose aspirin |
| title_fullStr | Release of tumor necrosis factor-α and prostanoids in whole blood cultures after
in vivo exposure to low-dose aspirin |
| title_full_unstemmed | Release of tumor necrosis factor-α and prostanoids in whole blood cultures after
in vivo exposure to low-dose aspirin |
| title_short | Release of tumor necrosis factor-α and prostanoids in whole blood cultures after
in vivo exposure to low-dose aspirin |
| title_sort | release of tumor necrosis factor α and prostanoids in whole blood cultures after in vivo exposure to low dose aspirin |
| url | http://dx.doi.org/10.1080/09629350120054554 |
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