DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies

DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies

Abstract Background Primary myelofibrosis (PMF) is a clonal blood disorder characterized by mutually exclusive driver mutations in JAK2, CALR, or MPL genes. So far, it is largely unclear if the driver mutations have a specific impact on DNA methylation (DNAm) profiles and how epigenetic alterations...

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Bibliographic Details
Main Authors: Esra Dursun Torlak, Vithurithra Tharmapalan, Kim Kricheldorf, Joelle Schifflers, Madeline Caduc, Martin Zenke, Steffen Koschmieder, Wolfgang Wagner
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Clinical Epigenetics
Subjects:
Primary myelofibrosis
DNA methylation
Myeloid malignancies
MPN
AML
JMML
Online Access:https://doi.org/10.1186/s13148-025-01877-1
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