Intestinal Permeability Assays: a Review
Aim. A literature review of intestinal permeability assessment techniques.Key points. The intestinal barrier is a functional entity separating the intestinal lumen and internal body, and intestinal permeability is a measure of the barrier functionality. The intestinal barrier integrity and permeabil...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2021-04-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/525 |
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| author | A. A. Iakupova S. R. Abdulkhakov R. K. Zalyalov A. G. Safin R. A. Abdulkhakov |
| author_facet | A. A. Iakupova S. R. Abdulkhakov R. K. Zalyalov A. G. Safin R. A. Abdulkhakov |
| author_sort | A. A. Iakupova |
| collection | DOAJ |
| description | Aim. A literature review of intestinal permeability assessment techniques.Key points. The intestinal barrier is a functional entity separating the intestinal lumen and internal body, and intestinal permeability is a measure of the barrier functionality. The intestinal barrier integrity and permeability assays differ by the application setting (in vivo or ex vivo), subject (human or animal), marker molecules used to assess permeability (ions, various size carbohydrates, macromolecules, antigens, bacterial products and bacteria), biomaterial for the marker concentration assays (peripheral blood, portal venous blood, urine, stool). Despite a great variety of methods for assessing intestinal permeability, their clinical application requires further studies due to a lack of standardisation, the complexity of selected techniques and occasional limited reliability of results.Conclusion. Further investigation and improvement of intestinal permeability assays is required. The assay and result standardisation will facilitate practice in functional and organic intestinal diseases, as well as allergies, diabetes mellitus, non-alcoholic fatty liver disease and some other illnesses. |
| format | Article |
| id | doaj-art-71d8e5a1586a4d9488cba31c40191507 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2021-04-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-71d8e5a1586a4d9488cba31c401915072025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732021-04-01311203010.22416/1382-4376-2021-31-1-20-30410Intestinal Permeability Assays: a ReviewA. A. Iakupova0S. R. Abdulkhakov1R. K. Zalyalov2A. G. Safin3R. A. Abdulkhakov4Kazan Federal UniversityKazan Federal University; Kazan State Medical UniversityKazan Federal University, University ClinicKazan Federal University, University ClinicKazan State Medical UniversityAim. A literature review of intestinal permeability assessment techniques.Key points. The intestinal barrier is a functional entity separating the intestinal lumen and internal body, and intestinal permeability is a measure of the barrier functionality. The intestinal barrier integrity and permeability assays differ by the application setting (in vivo or ex vivo), subject (human or animal), marker molecules used to assess permeability (ions, various size carbohydrates, macromolecules, antigens, bacterial products and bacteria), biomaterial for the marker concentration assays (peripheral blood, portal venous blood, urine, stool). Despite a great variety of methods for assessing intestinal permeability, their clinical application requires further studies due to a lack of standardisation, the complexity of selected techniques and occasional limited reliability of results.Conclusion. Further investigation and improvement of intestinal permeability assays is required. The assay and result standardisation will facilitate practice in functional and organic intestinal diseases, as well as allergies, diabetes mellitus, non-alcoholic fatty liver disease and some other illnesses.https://www.gastro-j.ru/jour/article/view/525intestinal permeabilityintestinal barriersugar testlipopolysaccharidetight junctions |
| spellingShingle | A. A. Iakupova S. R. Abdulkhakov R. K. Zalyalov A. G. Safin R. A. Abdulkhakov Intestinal Permeability Assays: a Review Российский журнал гастроэнтерологии, гепатологии, колопроктологии intestinal permeability intestinal barrier sugar test lipopolysaccharide tight junctions |
| title | Intestinal Permeability Assays: a Review |
| title_full | Intestinal Permeability Assays: a Review |
| title_fullStr | Intestinal Permeability Assays: a Review |
| title_full_unstemmed | Intestinal Permeability Assays: a Review |
| title_short | Intestinal Permeability Assays: a Review |
| title_sort | intestinal permeability assays a review |
| topic | intestinal permeability intestinal barrier sugar test lipopolysaccharide tight junctions |
| url | https://www.gastro-j.ru/jour/article/view/525 |
| work_keys_str_mv | AT aaiakupova intestinalpermeabilityassaysareview AT srabdulkhakov intestinalpermeabilityassaysareview AT rkzalyalov intestinalpermeabilityassaysareview AT agsafin intestinalpermeabilityassaysareview AT raabdulkhakov intestinalpermeabilityassaysareview |