Harnessing a Safe Novel Lipid Nanoparticle: Targeted Oral Delivery to Colonic Epithelial and Macrophage Cells in a Colitis Mouse Model

Harnessing a Safe Novel Lipid Nanoparticle: Targeted Oral Delivery to Colonic Epithelial and Macrophage Cells in a Colitis Mouse Model

A novel lipid nanoparticle (nLNP), formulated with three essential lipids to mimic ginger-derived exosomal particles, shows strong potential for delivering IL-22 mRNA specifically to the colon, presenting a unique oral drug delivery system for inflammatory bowel disease (IBD). However, its cellular...

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Bibliographic Details
Main Authors: Rabeya Jafrin Mow, Michal Pawel Kuczma, Xiaodi Shi, Sridhar Mani, Didier Merlin, Chunhua Yang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Nanomaterials
Subjects:
Inflammatory Bowel Disease (IBD)
macrophage-targeting
lipid labeling
colonic epithelium
flow cytometry
Online Access:https://www.mdpi.com/2079-4991/14/22/1800
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