High IL-8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapy
Abstract Objective Our earlier work reported the association of inflammatory biomarker with a reduced breast cancer chemotherapy relative dose intensity (RDI) resulting in an unfavourable survival outcome. This current study aimed to assess the prognostic role of inflammatory biomarkers in patients...
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BMC
2025-07-01
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| Online Access: | https://doi.org/10.1186/s13104-025-07353-6 |
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| author | Susanna Hilda Hutajulu Yufi Kartika Astari Dewi Kartikawati Paramita Jihan Fadlila Gubiananda Ado Pranawalingga Meita Ucche Lina Choridah Lidya Meidania Irianiwati Widodo Suwardjo Suwardjo Mardiah Suci Hardianti |
| author_facet | Susanna Hilda Hutajulu Yufi Kartika Astari Dewi Kartikawati Paramita Jihan Fadlila Gubiananda Ado Pranawalingga Meita Ucche Lina Choridah Lidya Meidania Irianiwati Widodo Suwardjo Suwardjo Mardiah Suci Hardianti |
| author_sort | Susanna Hilda Hutajulu |
| collection | DOAJ |
| description | Abstract Objective Our earlier work reported the association of inflammatory biomarker with a reduced breast cancer chemotherapy relative dose intensity (RDI) resulting in an unfavourable survival outcome. This current study aimed to assess the prognostic role of inflammatory biomarkers in patients with breast cancer, particularly Interleukin-8 (IL-8). Results This study included 168 breast cancer patients. The median follow-up was 24.3 (range 3–77) months. Kaplan-Meier and log-rank test showed that the 3-year overall survival (OS) in patients with high IL-8 plasma level (> 6.88pg/mL) were significantly lower than those with low level (≤ 6.88pg/mL) (59.6% vs. 76.4%, P = 0.049). Multivariate Cox regression analysis adjusted with stage and HER2 showed high IL-8 as prognostic factor for poor OS (HR 1.70, 95%CI [1.01–2.84], P = 0.044). Multivariate comparisons for disease-free survival (DFS) and progression-free survival (PFS) revealed none of the investigated inflammatory biomarkers having prognostic significance. More patients with older age and stage IV disease had a high IL-8 level than their counterparts (54 vs. 51 years, P = 0.020 and 61% vs. 39%, P = 0.012). High IL-8 level may serve as potential prognostic biomarker in the clinical setting in order to deliver more personalized care and strategy toward better outcomes. |
| format | Article |
| id | doaj-art-71d20476a76d4e569a91c9e74dd1cdbf |
| institution | DOAJ |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-71d20476a76d4e569a91c9e74dd1cdbf2025-08-20T03:04:12ZengBMCBMC Research Notes1756-05002025-07-011811810.1186/s13104-025-07353-6High IL-8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapySusanna Hilda Hutajulu0Yufi Kartika Astari1Dewi Kartikawati Paramita2Jihan Fadlila Gubiananda3Ado Pranawalingga4Meita Ucche5Lina Choridah6Lidya Meidania7Irianiwati Widodo8Suwardjo Suwardjo9Mardiah Suci Hardianti10Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalDivision of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Sardjito General HospitalDepartment of Histology and Cell Biology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaStudy Program of Specialty, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalStudy Program of Specialty, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalSiloam HospitalDivision of Radiodiagnosis, Department of Radiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalDivision of Radiotherapy, Department of Radiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalDepartment of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalDivision of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalAbstract Objective Our earlier work reported the association of inflammatory biomarker with a reduced breast cancer chemotherapy relative dose intensity (RDI) resulting in an unfavourable survival outcome. This current study aimed to assess the prognostic role of inflammatory biomarkers in patients with breast cancer, particularly Interleukin-8 (IL-8). Results This study included 168 breast cancer patients. The median follow-up was 24.3 (range 3–77) months. Kaplan-Meier and log-rank test showed that the 3-year overall survival (OS) in patients with high IL-8 plasma level (> 6.88pg/mL) were significantly lower than those with low level (≤ 6.88pg/mL) (59.6% vs. 76.4%, P = 0.049). Multivariate Cox regression analysis adjusted with stage and HER2 showed high IL-8 as prognostic factor for poor OS (HR 1.70, 95%CI [1.01–2.84], P = 0.044). Multivariate comparisons for disease-free survival (DFS) and progression-free survival (PFS) revealed none of the investigated inflammatory biomarkers having prognostic significance. More patients with older age and stage IV disease had a high IL-8 level than their counterparts (54 vs. 51 years, P = 0.020 and 61% vs. 39%, P = 0.012). High IL-8 level may serve as potential prognostic biomarker in the clinical setting in order to deliver more personalized care and strategy toward better outcomes.https://doi.org/10.1186/s13104-025-07353-6Breast neoplasmsInflammationInterleukin-8Interleukin-6SurvivalMortality |
| spellingShingle | Susanna Hilda Hutajulu Yufi Kartika Astari Dewi Kartikawati Paramita Jihan Fadlila Gubiananda Ado Pranawalingga Meita Ucche Lina Choridah Lidya Meidania Irianiwati Widodo Suwardjo Suwardjo Mardiah Suci Hardianti High IL-8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapy BMC Research Notes Breast neoplasms Inflammation Interleukin-8 Interleukin-6 Survival Mortality |
| title | High IL-8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapy |
| title_full | High IL-8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapy |
| title_fullStr | High IL-8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapy |
| title_full_unstemmed | High IL-8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapy |
| title_short | High IL-8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapy |
| title_sort | high il 8 plasma levels at baseline are predictive of poor overall survival in breast cancer patients receiving chemotherapy |
| topic | Breast neoplasms Inflammation Interleukin-8 Interleukin-6 Survival Mortality |
| url | https://doi.org/10.1186/s13104-025-07353-6 |
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