Roasted cashew nut supplement inhibits MCP-1 and inflammatory mediators to correct hypertension related liver failure induced by mixed-fractionated petroleum products via NOS-cAMP-PKA signaling pathway in male rats
People who expose to mixture of crude oil products had been reported to show several diseased-symptoms including hypertension, liver failure and chronic complications. The drugs for treating multiple-complex diseases are scarcely available. Cashew nut snack is known to check multiple diseases and ea...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Medicine in Omics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590124923000111 |
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| author | J.K. Akintunde A.O. Osifeso O.E. Eteng F.C. Thomas |
| author_facet | J.K. Akintunde A.O. Osifeso O.E. Eteng F.C. Thomas |
| author_sort | J.K. Akintunde |
| collection | DOAJ |
| description | People who expose to mixture of crude oil products had been reported to show several diseased-symptoms including hypertension, liver failure and chronic complications. The drugs for treating multiple-complex diseases are scarcely available. Cashew nut snack is known to check multiple diseases and easily accessible by indigenous-patients with no lethal-effects. Here, we examined the corrective-measures of roasted-cashew-nut (RCN) against hypertension co-morbidity with liver-failure in male rats on exposure to mixture of fractionated-petroleum-products (MFPP). Seventy (70) male-albino-rats (n = 10) were randomly exposed to MFPP for 14 days. Group 1: control rats were given basal-diet. Group 2 was given basal diet + 0.2 ml/day-MFPP. Group 3 was given 0.2 ml/day-MFPP + 50 mg/kg Atenolol. Group 4 was given 0.2 ml/day-MFPP + 10 % RCN. Group 5 was given 0.2 ml/day-MFPP + 20 % RCN. Group 6 was given 10 % RCN. Group 7 was given 20 % RCN. We found that high activities of liver-arginase, MAO-A, AChE, ADA, PDE-51 and ATP-hydrolytic-enzymes with low-bioavailability of NO-level on exposure to MFPP implicated liver-failure and hypertension. Also, up-regulation of HIF-1, p53, TNF-α, and MCP-1 with reduced-level of 1L-10 were connected to liver-failure and hypertension. However, post-treatment with 10 % RCN and 20 % RCN for 14-days corrected liver-failure and hypertension by inhibiting liver-arginase, MAO-A, AChE, ADA, PDE-51 and ATP-hydrolytic-enzymes. Also, liver-failure characterized by vascular-congestion and sinusoidal-dilation on exposure to 0.2 ml/day-MFPP was reversed by 10 % RCN and 20 % RCN via down-regulation of liver HIF-1, p53, TNF-α, MCP-1 with increased 1L-10. We conclude that 10 % RCN and 20 % RCN may be an innovative-snacks against hepatocellular damage co-morbidity with hypertension. |
| format | Article |
| id | doaj-art-71c9490d29cb476cbf3fd29ecd7f7a5f |
| institution | OA Journals |
| issn | 2590-1249 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | Medicine in Omics |
| spelling | doaj-art-71c9490d29cb476cbf3fd29ecd7f7a5f2025-08-20T02:18:57ZengElsevierMedicine in Omics2590-12492024-12-011210003010.1016/j.meomic.2023.100030Roasted cashew nut supplement inhibits MCP-1 and inflammatory mediators to correct hypertension related liver failure induced by mixed-fractionated petroleum products via NOS-cAMP-PKA signaling pathway in male ratsJ.K. Akintunde0A.O. Osifeso1O.E. Eteng2F.C. Thomas3Molecular Toxicology and Biomedical Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria; Corresponding author.Molecular Toxicology and Biomedical Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaMolecular Toxicology and Biomedical Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaDepartment of Physiology and Biochemistry, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, NigeriaPeople who expose to mixture of crude oil products had been reported to show several diseased-symptoms including hypertension, liver failure and chronic complications. The drugs for treating multiple-complex diseases are scarcely available. Cashew nut snack is known to check multiple diseases and easily accessible by indigenous-patients with no lethal-effects. Here, we examined the corrective-measures of roasted-cashew-nut (RCN) against hypertension co-morbidity with liver-failure in male rats on exposure to mixture of fractionated-petroleum-products (MFPP). Seventy (70) male-albino-rats (n = 10) were randomly exposed to MFPP for 14 days. Group 1: control rats were given basal-diet. Group 2 was given basal diet + 0.2 ml/day-MFPP. Group 3 was given 0.2 ml/day-MFPP + 50 mg/kg Atenolol. Group 4 was given 0.2 ml/day-MFPP + 10 % RCN. Group 5 was given 0.2 ml/day-MFPP + 20 % RCN. Group 6 was given 10 % RCN. Group 7 was given 20 % RCN. We found that high activities of liver-arginase, MAO-A, AChE, ADA, PDE-51 and ATP-hydrolytic-enzymes with low-bioavailability of NO-level on exposure to MFPP implicated liver-failure and hypertension. Also, up-regulation of HIF-1, p53, TNF-α, and MCP-1 with reduced-level of 1L-10 were connected to liver-failure and hypertension. However, post-treatment with 10 % RCN and 20 % RCN for 14-days corrected liver-failure and hypertension by inhibiting liver-arginase, MAO-A, AChE, ADA, PDE-51 and ATP-hydrolytic-enzymes. Also, liver-failure characterized by vascular-congestion and sinusoidal-dilation on exposure to 0.2 ml/day-MFPP was reversed by 10 % RCN and 20 % RCN via down-regulation of liver HIF-1, p53, TNF-α, MCP-1 with increased 1L-10. We conclude that 10 % RCN and 20 % RCN may be an innovative-snacks against hepatocellular damage co-morbidity with hypertension.http://www.sciencedirect.com/science/article/pii/S2590124923000111Roasted cashew nutMixtureFractionated petroleum productsHypertensionLiver damageRats |
| spellingShingle | J.K. Akintunde A.O. Osifeso O.E. Eteng F.C. Thomas Roasted cashew nut supplement inhibits MCP-1 and inflammatory mediators to correct hypertension related liver failure induced by mixed-fractionated petroleum products via NOS-cAMP-PKA signaling pathway in male rats Medicine in Omics Roasted cashew nut Mixture Fractionated petroleum products Hypertension Liver damage Rats |
| title | Roasted cashew nut supplement inhibits MCP-1 and inflammatory mediators to correct hypertension related liver failure induced by mixed-fractionated petroleum products via NOS-cAMP-PKA signaling pathway in male rats |
| title_full | Roasted cashew nut supplement inhibits MCP-1 and inflammatory mediators to correct hypertension related liver failure induced by mixed-fractionated petroleum products via NOS-cAMP-PKA signaling pathway in male rats |
| title_fullStr | Roasted cashew nut supplement inhibits MCP-1 and inflammatory mediators to correct hypertension related liver failure induced by mixed-fractionated petroleum products via NOS-cAMP-PKA signaling pathway in male rats |
| title_full_unstemmed | Roasted cashew nut supplement inhibits MCP-1 and inflammatory mediators to correct hypertension related liver failure induced by mixed-fractionated petroleum products via NOS-cAMP-PKA signaling pathway in male rats |
| title_short | Roasted cashew nut supplement inhibits MCP-1 and inflammatory mediators to correct hypertension related liver failure induced by mixed-fractionated petroleum products via NOS-cAMP-PKA signaling pathway in male rats |
| title_sort | roasted cashew nut supplement inhibits mcp 1 and inflammatory mediators to correct hypertension related liver failure induced by mixed fractionated petroleum products via nos camp pka signaling pathway in male rats |
| topic | Roasted cashew nut Mixture Fractionated petroleum products Hypertension Liver damage Rats |
| url | http://www.sciencedirect.com/science/article/pii/S2590124923000111 |
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