LncRNA16 inhibits pyroptosis and promotes platinum resistance in non-small cell lung cancer by sponging miRNA1827 to regulate MBD3/GSDME expression

LncRNA16 inhibits pyroptosis and promotes platinum resistance in non-small cell lung cancer by sponging miRNA1827 to regulate MBD3/GSDME expression

Abstract Background Platinum-based chemotherapy is the standard first-line cancer treatment. However, patients experience relapses due to chemoresistance. We found that long non-coding RNA 16 (lncRNA16) promotes platinum resistance and inhibits cell death in non-small cell lung cancer (NSCLC). Howev...

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Bibliographic Details
Main Authors: Yanfang Liu, Yuanjun Zeng, Sikai Wang, Jiangyan Chen, Zhouqi Wang, Yang Zhao, Kuiyu Gong, Guihua Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer Cell International
Subjects:
NSCLC
Platinum resistance
CeRNA
MiRNA Agomir
NcRNA
Online Access:https://doi.org/10.1186/s12935-025-03812-z
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