Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic review
Colorectal cancer (CRC) represents a relevant public health problem, with high incidence and mortality in Western countries. CRC can occur as sporadic (65%–75%), common familial (25%), or as a consequence of an inherited predisposition (up to 10%). While unravelling its genetic basis has been a long...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | Gut Microbiome |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2632289725000039/type/journal_article |
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| author | Luana Greco Federica Rubbino Clarissa Ferrari Michela Cameletti Fabio Grizzi Fabrizio Bonelli Alberto Malesci Massimiliano Mazzone Luigi Ricciardiello Luigi Laghi |
| author_facet | Luana Greco Federica Rubbino Clarissa Ferrari Michela Cameletti Fabio Grizzi Fabrizio Bonelli Alberto Malesci Massimiliano Mazzone Luigi Ricciardiello Luigi Laghi |
| author_sort | Luana Greco |
| collection | DOAJ |
| description | Colorectal cancer (CRC) represents a relevant public health problem, with high incidence and mortality in Western countries. CRC can occur as sporadic (65%–75%), common familial (25%), or as a consequence of an inherited predisposition (up to 10%). While unravelling its genetic basis has been a long trip leading to relevant clinical implementation over more than 30 years, other contributing factors remain to be clarified. Among these, micro-organisms have emerged as critical players in the development and progression of the disease, as well as for CRC treatment response. Fusobacterium nucleatum (Fn) has been associated with CRC development in both pre-clinical models and clinical settings. Fusobacteria are core members of the human oral microbiome, while being less prevalent in the healthy gut, prompting questions about their localization in CRC and its precursor lesions. This review aims to critically discuss the evidence connecting Fn with CRC pathogenesis, its molecular subtypes and clinical outcomes. |
| format | Article |
| id | doaj-art-71b79af8b0654e6cb4b4d1d480e3f92f |
| institution | OA Journals |
| issn | 2632-2897 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Gut Microbiome |
| spelling | doaj-art-71b79af8b0654e6cb4b4d1d480e3f92f2025-08-20T02:30:09ZengCambridge University PressGut Microbiome2632-28972025-01-01610.1017/gmb.2025.3Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic reviewLuana Greco0https://orcid.org/0000-0002-6507-3257Federica Rubbino1Clarissa Ferrari2Michela Cameletti3Fabio Grizzi4Fabrizio Bonelli5Alberto Malesci6Massimiliano Mazzone7Luigi Ricciardiello8Luigi Laghi9Laboratory of Molecular Gastroenterology, IRCCS Humanitas Research Hospital, Milan, ItalyLaboratory of Molecular Gastroenterology, IRCCS Humanitas Research Hospital, Milan, ItalyResearch and Clinical Trials Office, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, ItalyDepartment of Economics, University of Bergamo, Bergamo, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, Italy Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Milan, ItalyDiaSorin SpA, Saluggia, ItalyUniversità Vita-Salute San Raffaele, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, Italy Macrophage Dynamics Lab, IRCCS Humanitas Research Hospital, Milan, Italy Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, BelgiumDepartment of Gastroenterology, Hepatology and Nutrition, The University of Texas at MD Anderson Cancer Center, Houston, TX, USALaboratory of Molecular Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy Department of Medicine and Surgery, University of Parma, Parma, ItalyColorectal cancer (CRC) represents a relevant public health problem, with high incidence and mortality in Western countries. CRC can occur as sporadic (65%–75%), common familial (25%), or as a consequence of an inherited predisposition (up to 10%). While unravelling its genetic basis has been a long trip leading to relevant clinical implementation over more than 30 years, other contributing factors remain to be clarified. Among these, micro-organisms have emerged as critical players in the development and progression of the disease, as well as for CRC treatment response. Fusobacterium nucleatum (Fn) has been associated with CRC development in both pre-clinical models and clinical settings. Fusobacteria are core members of the human oral microbiome, while being less prevalent in the healthy gut, prompting questions about their localization in CRC and its precursor lesions. This review aims to critically discuss the evidence connecting Fn with CRC pathogenesis, its molecular subtypes and clinical outcomes.https://www.cambridge.org/core/product/identifier/S2632289725000039/type/journal_articlecolorectal cancerFusobacterium nucleatummicrobiomeprognosis |
| spellingShingle | Luana Greco Federica Rubbino Clarissa Ferrari Michela Cameletti Fabio Grizzi Fabrizio Bonelli Alberto Malesci Massimiliano Mazzone Luigi Ricciardiello Luigi Laghi Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic review Gut Microbiome colorectal cancer Fusobacterium nucleatum microbiome prognosis |
| title | Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic review |
| title_full | Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic review |
| title_fullStr | Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic review |
| title_full_unstemmed | Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic review |
| title_short | Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic review |
| title_sort | association of fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome a systematic review |
| topic | colorectal cancer Fusobacterium nucleatum microbiome prognosis |
| url | https://www.cambridge.org/core/product/identifier/S2632289725000039/type/journal_article |
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