Remapping the spatial distribution of neutralizing sites and their immunodominance on the capsid of different topotypes of FMDV serotype O by site-directed competitive ELISA for detection of neutralizing antibodies

Remapping the spatial distribution of neutralizing sites and their immunodominance on the capsid of different topotypes of FMDV serotype O by site-directed competitive ELISA for detection of neutralizing antibodies

ABSTRACT The foot-and-mouth disease virus (FMDV) serotype O contains at least five neutralizing antigenic sites, yet the structural relationship and antibody abundance remain poorly characterized. This study identifies six distinct neutralizing antigenic sites by evaluating 27 host-derived neutraliz...

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Main Authors: Qiongqiong Zhao, Fengjuan Li, Shulun Huang, Xiangchuan Xing, Ying Sun, Pinghua Li, Huifang Bao, Yuanfang Fu, Pu Sun, Xingwen Bai, Hong Yuan, Xueqing Ma, Zhixun Zhao, Jing Zhang, Jian Wang, Tao Wang, Dong Li, Qiang Zhang, Ping Qian, Yimei Cao, Kun Li, Xiangmin Li, Zengjun Lu
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:Microbiology Spectrum
Subjects:
foot-and-mouth disease virus
serotype O
neutralizing antigenic sites
neutralizing antibody
competitive ELISA
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03344-24
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