High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening
Primary aldosteronism is a main cause of secondary hypertension which can be effectively treated. The screening test for primary aldosteronism is benefit for minimizing damage to the patient. In the previous retrospective study, we obtained the optimal cutoff value of aldosterone-to-renin ratio dete...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2020/3934212 |
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| author | Wenbin Lin Yuzhe Li Dubo Chen Zhenrong Yao Hongxu Xu Yonghong Chen Jiahao Xiao Pinning Feng Wenjia Gan |
| author_facet | Wenbin Lin Yuzhe Li Dubo Chen Zhenrong Yao Hongxu Xu Yonghong Chen Jiahao Xiao Pinning Feng Wenjia Gan |
| author_sort | Wenbin Lin |
| collection | DOAJ |
| description | Primary aldosteronism is a main cause of secondary hypertension which can be effectively treated. The screening test for primary aldosteronism is benefit for minimizing damage to the patient. In the previous retrospective study, we obtained the optimal cutoff value of aldosterone-to-renin ratio detected by chemiluminescence assay, a newly developing method, and prompted its high efficiency in primary aldosteronism screening in upright position. In this study, we want to evaluate its efficiency in practical work. We used this ratio to continuously screen 238 patients, and 58 patients were finally diagnosed with primary aldosteronism. We found it had 86.13% accuracy rate in the upright position compared with the final clinical diagnosis. False negative and positive rates were 13.79% and 13.89%. Diagnostic sensitivity and specificity were 86.21% and 86.11%, which are slightly different from results in our previous study. False negative rate can be improved by combining the aldosterone-to-renin ratio with aldosterone concentration. We also found impaired glucose tolerance may be a reason for high false positive rate. Besides, chemiluminescence assay may be interfered in aldosterone detection. Although it has some shortcomings, chemiluminescence assay-detected aldosterone-to-renin ratio is a highly effective index for screening primary aldosteronism in practice. |
| format | Article |
| id | doaj-art-71a98f1d21f6437d86f48601fc5c613b |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-71a98f1d21f6437d86f48601fc5c613b2025-08-20T03:33:57ZengWileyInternational Journal of Hypertension2090-03842090-03922020-01-01202010.1155/2020/39342123934212High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism ScreeningWenbin Lin0Yuzhe Li1Dubo Chen2Zhenrong Yao3Hongxu Xu4Yonghong Chen5Jiahao Xiao6Pinning Feng7Wenjia Gan8Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Clinical Laboratory, The Sixth People’s Hospital of Longgang District, Shenzhen, ChinaReproductive Medicine Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaPrimary aldosteronism is a main cause of secondary hypertension which can be effectively treated. The screening test for primary aldosteronism is benefit for minimizing damage to the patient. In the previous retrospective study, we obtained the optimal cutoff value of aldosterone-to-renin ratio detected by chemiluminescence assay, a newly developing method, and prompted its high efficiency in primary aldosteronism screening in upright position. In this study, we want to evaluate its efficiency in practical work. We used this ratio to continuously screen 238 patients, and 58 patients were finally diagnosed with primary aldosteronism. We found it had 86.13% accuracy rate in the upright position compared with the final clinical diagnosis. False negative and positive rates were 13.79% and 13.89%. Diagnostic sensitivity and specificity were 86.21% and 86.11%, which are slightly different from results in our previous study. False negative rate can be improved by combining the aldosterone-to-renin ratio with aldosterone concentration. We also found impaired glucose tolerance may be a reason for high false positive rate. Besides, chemiluminescence assay may be interfered in aldosterone detection. Although it has some shortcomings, chemiluminescence assay-detected aldosterone-to-renin ratio is a highly effective index for screening primary aldosteronism in practice.http://dx.doi.org/10.1155/2020/3934212 |
| spellingShingle | Wenbin Lin Yuzhe Li Dubo Chen Zhenrong Yao Hongxu Xu Yonghong Chen Jiahao Xiao Pinning Feng Wenjia Gan High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening International Journal of Hypertension |
| title | High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening |
| title_full | High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening |
| title_fullStr | High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening |
| title_full_unstemmed | High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening |
| title_short | High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening |
| title_sort | high efficiency and problems of chemiluminescence assay detected aldosterone to renin ratio in practical primary aldosteronism screening |
| url | http://dx.doi.org/10.1155/2020/3934212 |
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