Propyl inulin nanoprebiotics as a synbiotic partner of Lactiplantibacillus plantarum for Inhibiting pathogenic infection in a mouse model
Listeria monocytogenes (LM) can proliferate significantly under refrigeration conditions, impacting food storage and safety for humans. This study investigated the effects of different forms of inulin on the antibacterial properties of lactic acid bacteria. Initially, propionylated inulin (IPr) and...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925001756 |
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| author | Xueyi Jing Weiyue Li Yang Gao Xin Qiao Yufei Cheng Wenjuan Zhang Lei Pu Hua Yang Jianbin Zhang Liang Hong |
| author_facet | Xueyi Jing Weiyue Li Yang Gao Xin Qiao Yufei Cheng Wenjuan Zhang Lei Pu Hua Yang Jianbin Zhang Liang Hong |
| author_sort | Xueyi Jing |
| collection | DOAJ |
| description | Listeria monocytogenes (LM) can proliferate significantly under refrigeration conditions, impacting food storage and safety for humans. This study investigated the effects of different forms of inulin on the antibacterial properties of lactic acid bacteria. Initially, propionylated inulin (IPr) and propyl-inulin nanoparticles (PIN) were synthesized and characterized. Characterization revealed that IPr had an irregular shape, while PIN exhibited a regular spherical structure, with a particle size of 949.7 and 434.4 nm, respectively. The zeta potential of PIN was measured at -51.16 mV. Subsequently, the effects of IPr and PIN on Lactiplantibacillus plantarum (LP) were studied, demonstrating that neither compound negatively affected LP's growth, but both significantly enhanced its antimicrobial activity. Animal studies indicated that LP and PIN had a considerable in vivo antimicrobial impact. They effectively repaired intestinal barrier damage caused by pathogens, alleviated liver injury, regulated immune responses, and restored gut microbiota composition. This study highlights the potent antimicrobial properties of enhanced nanoprebiotics and LP-based synbiotics, which inhibit the growth of psychrotrophic bacteria and promote animal gut health. The study innovatively develops nanoprebiotic-enhanced synbiotics, effectively combating infections, restoring gut health, and offering novel insights for creating additives to improve livestock product quality and shelf life. |
| format | Article |
| id | doaj-art-71a902fc0cec4127a758b623ee70d45e |
| institution | DOAJ |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-71a902fc0cec4127a758b623ee70d45e2025-08-20T03:20:58ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-06-011010083710.1016/j.carpta.2025.100837Propyl inulin nanoprebiotics as a synbiotic partner of Lactiplantibacillus plantarum for Inhibiting pathogenic infection in a mouse modelXueyi Jing0Weiyue Li1Yang Gao2Xin Qiao3Yufei Cheng4Wenjuan Zhang5Lei Pu6Hua Yang7Jianbin Zhang8Liang Hong9Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, ChinaTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China; Tianjin Modern Tianjiao Agricultural Technology Co., Ltd., Tianjin Key Laboratory of Green Ecological Feed, Tianjin 301800, China; Corresponding author.Listeria monocytogenes (LM) can proliferate significantly under refrigeration conditions, impacting food storage and safety for humans. This study investigated the effects of different forms of inulin on the antibacterial properties of lactic acid bacteria. Initially, propionylated inulin (IPr) and propyl-inulin nanoparticles (PIN) were synthesized and characterized. Characterization revealed that IPr had an irregular shape, while PIN exhibited a regular spherical structure, with a particle size of 949.7 and 434.4 nm, respectively. The zeta potential of PIN was measured at -51.16 mV. Subsequently, the effects of IPr and PIN on Lactiplantibacillus plantarum (LP) were studied, demonstrating that neither compound negatively affected LP's growth, but both significantly enhanced its antimicrobial activity. Animal studies indicated that LP and PIN had a considerable in vivo antimicrobial impact. They effectively repaired intestinal barrier damage caused by pathogens, alleviated liver injury, regulated immune responses, and restored gut microbiota composition. This study highlights the potent antimicrobial properties of enhanced nanoprebiotics and LP-based synbiotics, which inhibit the growth of psychrotrophic bacteria and promote animal gut health. The study innovatively develops nanoprebiotic-enhanced synbiotics, effectively combating infections, restoring gut health, and offering novel insights for creating additives to improve livestock product quality and shelf life.http://www.sciencedirect.com/science/article/pii/S2666893925001756NanoprebioticsLactiplantibacillus plantarumInulinSynbioticPathogenic infectionGut microbiota |
| spellingShingle | Xueyi Jing Weiyue Li Yang Gao Xin Qiao Yufei Cheng Wenjuan Zhang Lei Pu Hua Yang Jianbin Zhang Liang Hong Propyl inulin nanoprebiotics as a synbiotic partner of Lactiplantibacillus plantarum for Inhibiting pathogenic infection in a mouse model Carbohydrate Polymer Technologies and Applications Nanoprebiotics Lactiplantibacillus plantarum Inulin Synbiotic Pathogenic infection Gut microbiota |
| title | Propyl inulin nanoprebiotics as a synbiotic partner of Lactiplantibacillus plantarum for Inhibiting pathogenic infection in a mouse model |
| title_full | Propyl inulin nanoprebiotics as a synbiotic partner of Lactiplantibacillus plantarum for Inhibiting pathogenic infection in a mouse model |
| title_fullStr | Propyl inulin nanoprebiotics as a synbiotic partner of Lactiplantibacillus plantarum for Inhibiting pathogenic infection in a mouse model |
| title_full_unstemmed | Propyl inulin nanoprebiotics as a synbiotic partner of Lactiplantibacillus plantarum for Inhibiting pathogenic infection in a mouse model |
| title_short | Propyl inulin nanoprebiotics as a synbiotic partner of Lactiplantibacillus plantarum for Inhibiting pathogenic infection in a mouse model |
| title_sort | propyl inulin nanoprebiotics as a synbiotic partner of lactiplantibacillus plantarum for inhibiting pathogenic infection in a mouse model |
| topic | Nanoprebiotics Lactiplantibacillus plantarum Inulin Synbiotic Pathogenic infection Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925001756 |
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