Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study
Objective. To investigate the effect of magnesium (Mg) supplementation in healthy pregnant women for prevention of blood pressure increase. Secondary outcomes were comparison of biomarkers for hypertensive disorders and labour and fetal outcomes between the groups. Methods. Two hundred nulliparous h...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2018/4843159 |
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| _version_ | 1849414051332882432 |
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| author | Maria Bullarbo Helena Mattson Anna-Karin Broman Natalia Ödman Thorkild F. Nielsen |
| author_facet | Maria Bullarbo Helena Mattson Anna-Karin Broman Natalia Ödman Thorkild F. Nielsen |
| author_sort | Maria Bullarbo |
| collection | DOAJ |
| description | Objective. To investigate the effect of magnesium (Mg) supplementation in healthy pregnant women for prevention of blood pressure increase. Secondary outcomes were comparison of biomarkers for hypertensive disorders and labour and fetal outcomes between the groups. Methods. Two hundred nulliparous healthy pregnant women were double-blind randomized to receive Mg daily or placebo. Results. There were no differences in blood pressure increase. However, among the Mg-treated women, there was a significant negative correlation between increase in blood levels of magnesium and increase in systolic blood pressure (p = 0.042). Magnesium supplementation seems to be safe for both mother and infant. Conclusion. Magnesium supplementation in healthy first-time pregnant women is not to be recommended for prevention of blood pressure increase. Supplementation in risk pregnancies needs to be further investigated. The study is listed on the ISRCTN registry with study ID 13890849. |
| format | Article |
| id | doaj-art-71a7b87562d74a26b7acbb1bcd1dd495 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-71a7b87562d74a26b7acbb1bcd1dd4952025-08-20T03:33:57ZengWileyJournal of Pregnancy2090-27272090-27352018-01-01201810.1155/2018/48431594843159Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter StudyMaria Bullarbo0Helena Mattson1Anna-Karin Broman2Natalia Ödman3Thorkild F. Nielsen4Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenWomen’s Clinic, Södra Älvsborgs Hospital, Borås, SwedenWomen’s Clinic, Norra Älvsborgs Hospital, Trollhättan, SwedenWomen’s Clinic, Södra Älvsborgs Hospital, Borås, SwedenDepartment of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenObjective. To investigate the effect of magnesium (Mg) supplementation in healthy pregnant women for prevention of blood pressure increase. Secondary outcomes were comparison of biomarkers for hypertensive disorders and labour and fetal outcomes between the groups. Methods. Two hundred nulliparous healthy pregnant women were double-blind randomized to receive Mg daily or placebo. Results. There were no differences in blood pressure increase. However, among the Mg-treated women, there was a significant negative correlation between increase in blood levels of magnesium and increase in systolic blood pressure (p = 0.042). Magnesium supplementation seems to be safe for both mother and infant. Conclusion. Magnesium supplementation in healthy first-time pregnant women is not to be recommended for prevention of blood pressure increase. Supplementation in risk pregnancies needs to be further investigated. The study is listed on the ISRCTN registry with study ID 13890849.http://dx.doi.org/10.1155/2018/4843159 |
| spellingShingle | Maria Bullarbo Helena Mattson Anna-Karin Broman Natalia Ödman Thorkild F. Nielsen Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study Journal of Pregnancy |
| title | Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study |
| title_full | Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study |
| title_fullStr | Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study |
| title_full_unstemmed | Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study |
| title_short | Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study |
| title_sort | magnesium supplementation and blood pressure in pregnancy a double blind randomized multicenter study |
| url | http://dx.doi.org/10.1155/2018/4843159 |
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