α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

Abstract Prenatal nicotine exposure impairs fetal cortical grey matter volume, but the precise cellular mechanisms remain poorly understood. This study elucidates the role of nicotinic acetylcholine receptors (nAChRs) in progenitor cells and radial glia (RG) during human cortical development. We ide...

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Main Authors: Tanzila Mukhtar, Clara-Vita Siebert, Yuejun Wang, Mark-Phillip Pebworth, Matthew L. White, Tianzhi Wu, Tan Ieng Huang, Guolong Zuo, Jayden Ross, Jennifer Baltazar, Varun Upadhyay, Merut Shankar, Li Zhou, Isabel Lombardi-Coronel, Ishaan Mandala, Manal A. Adam, Shaohui Wang, Qiuli Bi, Marco F. M. Hoekman, Jingjing Li, Arnold R. Kriegstein
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61167-5
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