Unlocking the bioactive potential of seagrass-derived actinomycetota from the Tanzanian Coastline
Actinomycetota are renowned for their production of bioactive compounds, which play a crucial role in various healthcare industries. Significant research has been done on discovering active bioactive compounds from Actinomycetota strains in terrestrial soils, but very little has been done on marine...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
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| Series: | The Microbe |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S295019462500278X |
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| Summary: | Actinomycetota are renowned for their production of bioactive compounds, which play a crucial role in various healthcare industries. Significant research has been done on discovering active bioactive compounds from Actinomycetota strains in terrestrial soils, but very little has been done on marine Actinomycetota strains. In this study, we used ethyl acetate to prepare crude extracts from four selected Actinomycetota strains namely, Streptomyces (THD8), Micrococcus (SIS1), Micrococcus (SIS5), and Microbacterium (SIP6), isolated from seagrass meadows in Tanzania, and the gas chromatography-mass spectrometry technique was used to identify the compounds they contain. Fifty nine bioactive compounds from the Actinomycetota were identified, of which 14 have no previously reported biological activities; an important new finding of this study. Furthermore, most of these identified compounds are reported for the first time in Actinomycetota species. The most commonly found compounds were n-hexadecanoic acid, 7,9-di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, and azelaic acid. Streptomyces was found to contain more compounds compared to the other three Actinomycetota species studied. These results demonstrate the therapeutic potential of Actinomycetota associated with the Tanzanian seagrass species that may be leveraged for novel therapeutic strategies. |
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| ISSN: | 2950-1946 |