Metals (Cr, Mn, Co, Ni) concentration in the blood plasma and urine od Polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposure
Objectives The study investigated the concentrations of metals (chromium [Cr], manganese [Mn], cobalt [Co], nickel [Ni]) in the blood plasma and urine of Polish welders exposed to these elements contained in welding dust/fumes based on the results of biological monitoring, analyze the interrelations...
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| Format: | Article |
| Language: | English |
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Nofer Institute of Occupational Medicine
2025-02-01
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| Series: | International Journal of Occupational Medicine and Environmental Health |
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| Online Access: | https://ijomeh.eu/Metals-Cr-Mn-Co-Ni-concentration-in-the-blood-plasma-and-urine-od-Polish-welders,200203,0,2.html |
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| _version_ | 1850227119662039040 |
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| author | Wojciech Wąsowicz Beata Janasik Edyta Reszka Edyta Kasperczyk Jędrzej Chrzanowski Wojciech Fendler |
| author_facet | Wojciech Wąsowicz Beata Janasik Edyta Reszka Edyta Kasperczyk Jędrzej Chrzanowski Wojciech Fendler |
| author_sort | Wojciech Wąsowicz |
| collection | DOAJ |
| description | Objectives
The study investigated the concentrations of metals (chromium [Cr], manganese [Mn], cobalt [Co], nickel [Ni]) in the blood plasma and urine of Polish welders exposed to these elements contained in welding dust/fumes based on the results of biological monitoring, analyze the interrelationships between these elements, and attempt to correlate these data with telomere length. It is believed that telomere length can be considered a marker of exposure, including occupational. Analysis of questionnaire surveys was also taken into consideration.
Material and Methods
The study included 118 male welders and 51 age-matched male controls. Metals analysis in plasma and urine were determined by ICP-MS technique. Telomere length was measured in blood genomic DNA using the qRT-PCR method.
Results
Welders had significantly higher plasma levels of Cr, Ni, and Mn (p < 0.0001, respectively). Total concentrations of Cr, Ni, and Mn in the urine of pre-shift subjects were significantly higher compared to controls. Cobalt concentration in urine of exposed welders was significantly higher (p < 0.02) than in control group. Telomere length was exactly the same in
the welder group compared to the control (mean ± standard deviation 0.99±0.41 vs. 0.99±0.52, respectively). Plasma and urine metal concentrations and telomere length were also studied in groups of welders in relation to personal protection equipment. Differences were found in plasma and urine metal concentrations according to the aspirators used. Statistically significant linear correlations were found between plasma and urine concentrations of the determined elements both before and after the work shift.
Conclusions
The findings suggest a positive relationship between Ni and Mn (end-shift) concentrations and telomere length, the effect which remained statistically significant even after adjusting for age and metabolic status. This indicates a complex interplay between metal exposure and biological aging markers. However, the relationship between exposure to welding fumes and changes in telomere length in welders requires further in-depth research. Int J Occup Med Environ Health. 2025;38(1):70–90 |
| format | Article |
| id | doaj-art-7193478d5fd04466bc06caa20fb31b5d |
| institution | OA Journals |
| issn | 1232-1087 1896-494X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nofer Institute of Occupational Medicine |
| record_format | Article |
| series | International Journal of Occupational Medicine and Environmental Health |
| spelling | doaj-art-7193478d5fd04466bc06caa20fb31b5d2025-08-20T02:04:54ZengNofer Institute of Occupational MedicineInternational Journal of Occupational Medicine and Environmental Health1232-10871896-494X2025-02-01381709010.13075/ijomeh.1896.02493200203Metals (Cr, Mn, Co, Ni) concentration in the blood plasma and urine od Polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposureWojciech Wąsowicz0Beata Janasik1Edyta Reszka2Edyta Kasperczyk3Jędrzej Chrzanowski4Wojciech Fendler5Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Biological and Environmental Monitoring)Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Biological and Environmental Monitoring)Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Translational Research)Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Translational Research)Medical University of Lodz, Łódź, Poland (Department of Biostatistics and Translational Medicine)Medical University of Lodz, Łódź, Poland (Department of Biostatistics and Translational Medicine)Objectives The study investigated the concentrations of metals (chromium [Cr], manganese [Mn], cobalt [Co], nickel [Ni]) in the blood plasma and urine of Polish welders exposed to these elements contained in welding dust/fumes based on the results of biological monitoring, analyze the interrelationships between these elements, and attempt to correlate these data with telomere length. It is believed that telomere length can be considered a marker of exposure, including occupational. Analysis of questionnaire surveys was also taken into consideration. Material and Methods The study included 118 male welders and 51 age-matched male controls. Metals analysis in plasma and urine were determined by ICP-MS technique. Telomere length was measured in blood genomic DNA using the qRT-PCR method. Results Welders had significantly higher plasma levels of Cr, Ni, and Mn (p < 0.0001, respectively). Total concentrations of Cr, Ni, and Mn in the urine of pre-shift subjects were significantly higher compared to controls. Cobalt concentration in urine of exposed welders was significantly higher (p < 0.02) than in control group. Telomere length was exactly the same in the welder group compared to the control (mean ± standard deviation 0.99±0.41 vs. 0.99±0.52, respectively). Plasma and urine metal concentrations and telomere length were also studied in groups of welders in relation to personal protection equipment. Differences were found in plasma and urine metal concentrations according to the aspirators used. Statistically significant linear correlations were found between plasma and urine concentrations of the determined elements both before and after the work shift. Conclusions The findings suggest a positive relationship between Ni and Mn (end-shift) concentrations and telomere length, the effect which remained statistically significant even after adjusting for age and metabolic status. This indicates a complex interplay between metal exposure and biological aging markers. However, the relationship between exposure to welding fumes and changes in telomere length in welders requires further in-depth research. Int J Occup Med Environ Health. 2025;38(1):70–90https://ijomeh.eu/Metals-Cr-Mn-Co-Ni-concentration-in-the-blood-plasma-and-urine-od-Polish-welders,200203,0,2.htmlbiological monitoringmetalsweldersurinewelding fumestelomere length |
| spellingShingle | Wojciech Wąsowicz Beata Janasik Edyta Reszka Edyta Kasperczyk Jędrzej Chrzanowski Wojciech Fendler Metals (Cr, Mn, Co, Ni) concentration in the blood plasma and urine od Polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposure International Journal of Occupational Medicine and Environmental Health biological monitoring metals welders urine welding fumes telomere length |
| title | Metals (Cr, Mn, Co, Ni) concentration in the blood plasma and urine od Polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposure |
| title_full | Metals (Cr, Mn, Co, Ni) concentration in the blood plasma and urine od Polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposure |
| title_fullStr | Metals (Cr, Mn, Co, Ni) concentration in the blood plasma and urine od Polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposure |
| title_full_unstemmed | Metals (Cr, Mn, Co, Ni) concentration in the blood plasma and urine od Polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposure |
| title_short | Metals (Cr, Mn, Co, Ni) concentration in the blood plasma and urine od Polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposure |
| title_sort | metals cr mn co ni concentration in the blood plasma and urine od polish welders and telomere length as an potential indicator of toxicity of metals welding fumes exposure |
| topic | biological monitoring metals welders urine welding fumes telomere length |
| url | https://ijomeh.eu/Metals-Cr-Mn-Co-Ni-concentration-in-the-blood-plasma-and-urine-od-Polish-welders,200203,0,2.html |
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