CAR T-cell therapy for systemic lupus erythematosus: current status and future perspectives

CAR T-cell therapy for systemic lupus erythematosus: current status and future perspectives

Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are debilitating autoimmune disorders characterized by pathological autoantibodies production and immune dysfunction, causing chronic inflammation and multi-organ damage. Despite current treatments with antimalarial drugs, glucocorticoids,...

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Bibliographic Details
Main Authors: Jincai Zhou, Bixia Lei, Feifei Shi, Xinran Luo, Kai Wu, Yanhong Xu, Yuting Zhang, Rongjiao Liu, Huajing Wang, Joy Zhou, Xiaowen He
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
chimeric antigen receptor T-cell
CD19
BCMA
therapeutic strategy
clinical implications
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1476859/full
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