Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysis from 1990 to 2021
PurposeThis study aims to explore global, regional, and national trends in the prevalence of depression and disability-adjusted life years (DALYs) among women of childbearing age from 1990 to 2021, as well as to project future trends from 2022 to 2040.MethodsThis research analyzes the prevalence of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Global Women's Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgwh.2025.1629747/full |
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| author | Yuhang Yang Yuyuan Hu Yuan He Wei Zhang Jinghan Jia Yibo Xu Yan Li Jinxi Wang |
| author_facet | Yuhang Yang Yuyuan Hu Yuan He Wei Zhang Jinghan Jia Yibo Xu Yan Li Jinxi Wang |
| author_sort | Yuhang Yang |
| collection | DOAJ |
| description | PurposeThis study aims to explore global, regional, and national trends in the prevalence of depression and disability-adjusted life years (DALYs) among women of childbearing age from 1990 to 2021, as well as to project future trends from 2022 to 2040.MethodsThis research analyzes the prevalence of depression and Disability-Adjusted Life Years (DALYs) among Women of Childbearing Age (WCBA) using data from the Global Burden of Disease (GBD) database, covering the period from 1990 to 2021. We evaluate trends in the burden of depression in WCBA through estimated annual percentage change (EAPC) and percentage change, as well as annual percentage change (APC) and average annual percentage change (AAPC) derived from Joinpoint regression analyses. Additionally, we employ age-period-cohort modeling to provide a more comprehensive evaluation of the prevalence of WCBA and the burden of DALYs, including future projections.ResultsIn 2021, it was estimated that there were 121.24 million cases of depression among women of childbearing age worldwide, with disability-adjusted life years (DALYs) accounting for 21.04 million cases. When compared to figures from 1990, these numbers indicate percentage increases of 68% and 69%, respectively. Moreover, despite an overall increase in both global prevalence and DALY rates, this rise was not considered statistically significant, as reflected by an estimated annual percentage change (EAPC) of −0.02 (95% confidence interval: −0.17 to 0.13) for prevalence and −0.06 (95% CI: −0.24 to 0.12) for DALYs. Furthermore, the average annual percentage change (AAPC) was computed to be 0.4789 (95% CI: 0.3289–0.6295; P < 0.001) for prevalence and 0.524 (95% CI: 0.3756–0.6725; P < 0.001) for DALYs. Projections made using our Bayesian age–period–cohort (BAPC) model suggest that we can expect a considerable increase in the global prevalence of depression and DALY rates among women of childbearing age by the year 2040. |
| format | Article |
| id | doaj-art-718fee6f3a8e4c5f956bed273cb31073 |
| institution | Kabale University |
| issn | 2673-5059 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Global Women's Health |
| spelling | doaj-art-718fee6f3a8e4c5f956bed273cb310732025-08-20T04:02:51ZengFrontiers Media S.A.Frontiers in Global Women's Health2673-50592025-08-01610.3389/fgwh.2025.16297471629747Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysis from 1990 to 2021Yuhang Yang0Yuyuan Hu1Yuan He2Wei Zhang3Jinghan Jia4Yibo Xu5Yan Li6Jinxi Wang7Division of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDivision of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaHepatobiliary Surgery, Baogang Hospital of InnerMongolia, Baotou, ChinaDivision of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDivision of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaFaculty of Clinical Medicine, Xi’an Medical University, Xi’an, ChinaNeurology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDivision of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaPurposeThis study aims to explore global, regional, and national trends in the prevalence of depression and disability-adjusted life years (DALYs) among women of childbearing age from 1990 to 2021, as well as to project future trends from 2022 to 2040.MethodsThis research analyzes the prevalence of depression and Disability-Adjusted Life Years (DALYs) among Women of Childbearing Age (WCBA) using data from the Global Burden of Disease (GBD) database, covering the period from 1990 to 2021. We evaluate trends in the burden of depression in WCBA through estimated annual percentage change (EAPC) and percentage change, as well as annual percentage change (APC) and average annual percentage change (AAPC) derived from Joinpoint regression analyses. Additionally, we employ age-period-cohort modeling to provide a more comprehensive evaluation of the prevalence of WCBA and the burden of DALYs, including future projections.ResultsIn 2021, it was estimated that there were 121.24 million cases of depression among women of childbearing age worldwide, with disability-adjusted life years (DALYs) accounting for 21.04 million cases. When compared to figures from 1990, these numbers indicate percentage increases of 68% and 69%, respectively. Moreover, despite an overall increase in both global prevalence and DALY rates, this rise was not considered statistically significant, as reflected by an estimated annual percentage change (EAPC) of −0.02 (95% confidence interval: −0.17 to 0.13) for prevalence and −0.06 (95% CI: −0.24 to 0.12) for DALYs. Furthermore, the average annual percentage change (AAPC) was computed to be 0.4789 (95% CI: 0.3289–0.6295; P < 0.001) for prevalence and 0.524 (95% CI: 0.3756–0.6725; P < 0.001) for DALYs. Projections made using our Bayesian age–period–cohort (BAPC) model suggest that we can expect a considerable increase in the global prevalence of depression and DALY rates among women of childbearing age by the year 2040.https://www.frontiersin.org/articles/10.3389/fgwh.2025.1629747/fulldepressionwomen of childbearing ageburden of diseasejoinpoint regression analysisage-period-cohort analysis |
| spellingShingle | Yuhang Yang Yuyuan Hu Yuan He Wei Zhang Jinghan Jia Yibo Xu Yan Li Jinxi Wang Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysis from 1990 to 2021 Frontiers in Global Women's Health depression women of childbearing age burden of disease joinpoint regression analysis age-period-cohort analysis |
| title | Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysis from 1990 to 2021 |
| title_full | Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysis from 1990 to 2021 |
| title_fullStr | Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysis from 1990 to 2021 |
| title_full_unstemmed | Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysis from 1990 to 2021 |
| title_short | Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysis from 1990 to 2021 |
| title_sort | global regional and national trends in depressive disorder prevalence and dalys among women of childbearing age from 1990 to 2021 and projections to 2040 a comprehensive analysis from 1990 to 2021 |
| topic | depression women of childbearing age burden of disease joinpoint regression analysis age-period-cohort analysis |
| url | https://www.frontiersin.org/articles/10.3389/fgwh.2025.1629747/full |
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