Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of Russia
Aim. To determine the associations of allelic variants of the CYP2C19 gene with coronary atherosclerosis and ischemic events in patients with myocardial infarction (MI) living in the Khanty-Mansi Autonomous Okrug — Yugra.Material and methods. This prospective observational study included 203 patient...
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«FIRMA «SILICEA» LLC
2023-11-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5533 |
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| author | A. S. Vorobyov G. I. Lifshits E. M. Zelenskaya K. Yu. Batueva L. V. Kovalenko I. A. Urvantseva M. Yu. Donnikov A. V. Morozkina K. Yu. Nikolaev |
| author_facet | A. S. Vorobyov G. I. Lifshits E. M. Zelenskaya K. Yu. Batueva L. V. Kovalenko I. A. Urvantseva M. Yu. Donnikov A. V. Morozkina K. Yu. Nikolaev |
| author_sort | A. S. Vorobyov |
| collection | DOAJ |
| description | Aim. To determine the associations of allelic variants of the CYP2C19 gene with coronary atherosclerosis and ischemic events in patients with myocardial infarction (MI) living in the Khanty-Mansi Autonomous Okrug — Yugra.Material and methods. This prospective observational study included 203 patients with acute MI who underwent percutaneous coronary intervention. Patients also underwent genetic testing using real-time polymerase chain reaction to determine allelic variants of the CYP2C19 gene. Using biostatistical analysis methods, associations were established between the genotypes of patients with MI, their clinical characteristics and major ischemic events over 7-year follow-up.Results. Significant associations were identified between allelic variants of CYP2C19*2 (*1/*2 and *2/*2) and smoking, right ventricular volume and glomerular filtration rate (GFR). The presence of the allelic variant CYP2C19*3 (*3/*3) was associated with GFR ³90 ml/min/1,73 m2 and impaired glucose tolerance. A significant association was established between the CYP2C19*17 alleles (*1/*17, *17/*17) with coronary atherosclerosis, smoking, levels of troponin T, aspartate aminotransferase, total cholesterol, left ventricular posterior wall thickness, and a history of myocardial infarction. Data from multivariate analysis showed a clear association of allelic variants of CYP2C19*2 (*1/*2 and *2/*2) with the composite endpoint of 7-year follow-up (death, recurrent myocardial infarction, stent/bypass thrombosis, myocardial revascularization). A significant influence of CYP2C19*17 genotypes (*1/*17 and *17/*17) on myocardial revascularization in patients in the post-infarction period was also determined.Conclusion. CYP2C19*2 genotypes (*1/*2 and *2/*2) in MI patients living in Khanty-Mansi Autonomous Okrug — Yugra are clearly associated with ischemic events during a 7-year follow-up. CYP2C19*17 genotypes (*1/*17 and *17/*17) are clearly associated with coronary atherosclerosis and myocardial revascularization in the long-term post-infarction period. |
| format | Article |
| id | doaj-art-71896bef8fca4642bf8727fc9b2ddbac |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-11-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-71896bef8fca4642bf8727fc9b2ddbac2025-08-20T03:43:37Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-11-01281010.15829/1560-4071-2023-55333879Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of RussiaA. S. Vorobyov0G. I. Lifshits1E. M. Zelenskaya2K. Yu. Batueva3L. V. Kovalenko4I. A. Urvantseva5M. Yu. Donnikov6A. V. Morozkina7K. Yu. Nikolaev8Yugra Surgut State University; Center for Diagnostics and Cardiovascular SurgeryInstitute of Chemical Biology and Fundamental MedicineYugra Surgut State University; Institute of Chemical Biology and Fundamental MedicineYugra Surgut State University; Center for Diagnostics and Cardiovascular SurgeryYugra Surgut State UniversityYugra Surgut State University; Center for Diagnostics and Cardiovascular SurgeryYugra Surgut State UniversityYugra Surgut State UniversityYugra Surgut State University; Research Institute of Therapy and Preventive Medicine – branch of the Institute of Cytology and GeneticsAim. To determine the associations of allelic variants of the CYP2C19 gene with coronary atherosclerosis and ischemic events in patients with myocardial infarction (MI) living in the Khanty-Mansi Autonomous Okrug — Yugra.Material and methods. This prospective observational study included 203 patients with acute MI who underwent percutaneous coronary intervention. Patients also underwent genetic testing using real-time polymerase chain reaction to determine allelic variants of the CYP2C19 gene. Using biostatistical analysis methods, associations were established between the genotypes of patients with MI, their clinical characteristics and major ischemic events over 7-year follow-up.Results. Significant associations were identified between allelic variants of CYP2C19*2 (*1/*2 and *2/*2) and smoking, right ventricular volume and glomerular filtration rate (GFR). The presence of the allelic variant CYP2C19*3 (*3/*3) was associated with GFR ³90 ml/min/1,73 m2 and impaired glucose tolerance. A significant association was established between the CYP2C19*17 alleles (*1/*17, *17/*17) with coronary atherosclerosis, smoking, levels of troponin T, aspartate aminotransferase, total cholesterol, left ventricular posterior wall thickness, and a history of myocardial infarction. Data from multivariate analysis showed a clear association of allelic variants of CYP2C19*2 (*1/*2 and *2/*2) with the composite endpoint of 7-year follow-up (death, recurrent myocardial infarction, stent/bypass thrombosis, myocardial revascularization). A significant influence of CYP2C19*17 genotypes (*1/*17 and *17/*17) on myocardial revascularization in patients in the post-infarction period was also determined.Conclusion. CYP2C19*2 genotypes (*1/*2 and *2/*2) in MI patients living in Khanty-Mansi Autonomous Okrug — Yugra are clearly associated with ischemic events during a 7-year follow-up. CYP2C19*17 genotypes (*1/*17 and *17/*17) are clearly associated with coronary atherosclerosis and myocardial revascularization in the long-term post-infarction period.https://russjcardiol.elpub.ru/jour/article/view/5533myocardial infarctioncyp2c19 genotypescoronary atherosclerosisischemic eventsnorthern region of russia |
| spellingShingle | A. S. Vorobyov G. I. Lifshits E. M. Zelenskaya K. Yu. Batueva L. V. Kovalenko I. A. Urvantseva M. Yu. Donnikov A. V. Morozkina K. Yu. Nikolaev Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of Russia Российский кардиологический журнал myocardial infarction cyp2c19 genotypes coronary atherosclerosis ischemic events northern region of russia |
| title | Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of Russia |
| title_full | Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of Russia |
| title_fullStr | Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of Russia |
| title_full_unstemmed | Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of Russia |
| title_short | Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of Russia |
| title_sort | clinically significant cyp2c19 genotypes in patients with myocardial infarction in the northern region of russia |
| topic | myocardial infarction cyp2c19 genotypes coronary atherosclerosis ischemic events northern region of russia |
| url | https://russjcardiol.elpub.ru/jour/article/view/5533 |
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