Increased ventral striatal volume in college-aged binge drinkers.
<h4>Background</h4>Binge drinking is a serious public health issue associated with cognitive, physiological, and anatomical differences from healthy individuals. No studies, however, have reported subcortical grey matter differences in this population. To address this, we compared the gr...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074164&type=printable |
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| author | Nicholas A Howell Yulia Worbe Iris Lange Roger Tait Michael Irvine Paula Banca Neil A Harrison Edward T Bullmore William D Hutchison Valerie Voon |
| author_facet | Nicholas A Howell Yulia Worbe Iris Lange Roger Tait Michael Irvine Paula Banca Neil A Harrison Edward T Bullmore William D Hutchison Valerie Voon |
| author_sort | Nicholas A Howell |
| collection | DOAJ |
| description | <h4>Background</h4>Binge drinking is a serious public health issue associated with cognitive, physiological, and anatomical differences from healthy individuals. No studies, however, have reported subcortical grey matter differences in this population. To address this, we compared the grey matter volumes of college-age binge drinkers and healthy controls, focusing on the ventral striatum, hippocampus and amygdala.<h4>Method</h4>T1-weighted images of 19 binge drinkers and 19 healthy volunteers were analyzed using voxel-based morphometry. Structural data were also covaried with Alcohol Use Disorders Identification Test (AUDIT) scores. Cluster-extent threshold and small volume corrections were both used to analyze imaging data.<h4>Results</h4>Binge drinkers had significantly larger ventral striatal grey matter volumes compared to controls. There were no between group differences in hippocampal or amygdalar volume. Ventral striatal, amygdalar, and hippocampal volumes were also negatively related to AUDIT scores across groups.<h4>Conclusions</h4>Our findings stand in contrast to the lower ventral striatal volume previously observed in more severe forms of alcohol use disorders, suggesting that college-age binge drinkers may represent a distinct population from those groups. These findings may instead represent early sequelae, compensatory effects of repeated binge and withdrawal, or an endophenotypic risk factor. |
| format | Article |
| id | doaj-art-7183bd9eb2f9499c842f0df6788d38b2 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7183bd9eb2f9499c842f0df6788d38b22025-08-20T02:35:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7416410.1371/journal.pone.0074164Increased ventral striatal volume in college-aged binge drinkers.Nicholas A HowellYulia WorbeIris LangeRoger TaitMichael IrvinePaula BancaNeil A HarrisonEdward T BullmoreWilliam D HutchisonValerie Voon<h4>Background</h4>Binge drinking is a serious public health issue associated with cognitive, physiological, and anatomical differences from healthy individuals. No studies, however, have reported subcortical grey matter differences in this population. To address this, we compared the grey matter volumes of college-age binge drinkers and healthy controls, focusing on the ventral striatum, hippocampus and amygdala.<h4>Method</h4>T1-weighted images of 19 binge drinkers and 19 healthy volunteers were analyzed using voxel-based morphometry. Structural data were also covaried with Alcohol Use Disorders Identification Test (AUDIT) scores. Cluster-extent threshold and small volume corrections were both used to analyze imaging data.<h4>Results</h4>Binge drinkers had significantly larger ventral striatal grey matter volumes compared to controls. There were no between group differences in hippocampal or amygdalar volume. Ventral striatal, amygdalar, and hippocampal volumes were also negatively related to AUDIT scores across groups.<h4>Conclusions</h4>Our findings stand in contrast to the lower ventral striatal volume previously observed in more severe forms of alcohol use disorders, suggesting that college-age binge drinkers may represent a distinct population from those groups. These findings may instead represent early sequelae, compensatory effects of repeated binge and withdrawal, or an endophenotypic risk factor.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074164&type=printable |
| spellingShingle | Nicholas A Howell Yulia Worbe Iris Lange Roger Tait Michael Irvine Paula Banca Neil A Harrison Edward T Bullmore William D Hutchison Valerie Voon Increased ventral striatal volume in college-aged binge drinkers. PLoS ONE |
| title | Increased ventral striatal volume in college-aged binge drinkers. |
| title_full | Increased ventral striatal volume in college-aged binge drinkers. |
| title_fullStr | Increased ventral striatal volume in college-aged binge drinkers. |
| title_full_unstemmed | Increased ventral striatal volume in college-aged binge drinkers. |
| title_short | Increased ventral striatal volume in college-aged binge drinkers. |
| title_sort | increased ventral striatal volume in college aged binge drinkers |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074164&type=printable |
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