25 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphology
It has been recognized that subtle, cosmetically insignificant anomalies tend to occur cumulatively in diseases with neurodevelopmental origin. These visible signs of morphogenesis errors are called minor physical anomalies (MPAs), serving as sensitive external markers of abnormal neurodevelopment....
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1479156/full |
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| author | Dalma Tényi Györgyi Csábi József Janszky Róbert Herold Tamás Tényi |
| author_facet | Dalma Tényi Györgyi Csábi József Janszky Róbert Herold Tamás Tényi |
| author_sort | Dalma Tényi |
| collection | DOAJ |
| description | It has been recognized that subtle, cosmetically insignificant anomalies tend to occur cumulatively in diseases with neurodevelopmental origin. These visible signs of morphogenesis errors are called minor physical anomalies (MPAs), serving as sensitive external markers of abnormal neurodevelopment. After the introduction of the Waldrop Scale, the studies conducted on MPAs in diseases with neurodevelopmental origin gave conflicting results. It has been debated that this discrepancy can be – at least partly – attributed to the use of the Waldrop Scale. Understanding the need of a comprehensive scale of MPAs that also differentiates according to the time of development, Hungarian pediatrician professor of University of Pécs, Károly Méhes developed a scale with 57 items, the only scale differentiating minor malformations from phenogenetic variants. With the use of the Méhes Scale, our research group has been investigating the role of abnormal neurodevelopment in different neuropsychiatric and neurologic disorders since 1997. 25 years into our research, in this review we summarize the results of our 18 research articles on MPAs in different diseases. We have found an increased number of MPAs, especially in the head and mouth region, in patients with schizophrenia, bipolar disorder, Tourette syndrome, autism and many epilepsy syndromes, fortifying the role of abnormal neurodevelopment in these diseases. Moreover, an increased number of MPAs was detected among the first-degree relatives of patients with schizophrenia and bipolar I disorder, supporting the hypothesis about MPAs being endophenotypic trait markers. |
| format | Article |
| id | doaj-art-7178b7d673f24532a2cd2c4f683c10db |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-7178b7d673f24532a2cd2c4f683c10db2025-08-20T02:18:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-11-011510.3389/fpsyt.2024.1479156147915625 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphologyDalma Tényi0Györgyi Csábi1József Janszky2Róbert Herold3Tamás Tényi4Department of Neurology, Medical School, Clinical Center, University of Pécs, Pécs, HungaryDepartment of Pediatrics, Medical School, Clinical Center, University of Pécs, Pécs, HungaryDepartment of Neurology, Medical School, Clinical Center, University of Pécs, Pécs, HungaryDepartment of Psychiatry and Psychotherapy, Medical School, Clinical Center, University of Pécs, Pécs, HungaryDepartment of Psychiatry and Psychotherapy, Medical School, Clinical Center, University of Pécs, Pécs, HungaryIt has been recognized that subtle, cosmetically insignificant anomalies tend to occur cumulatively in diseases with neurodevelopmental origin. These visible signs of morphogenesis errors are called minor physical anomalies (MPAs), serving as sensitive external markers of abnormal neurodevelopment. After the introduction of the Waldrop Scale, the studies conducted on MPAs in diseases with neurodevelopmental origin gave conflicting results. It has been debated that this discrepancy can be – at least partly – attributed to the use of the Waldrop Scale. Understanding the need of a comprehensive scale of MPAs that also differentiates according to the time of development, Hungarian pediatrician professor of University of Pécs, Károly Méhes developed a scale with 57 items, the only scale differentiating minor malformations from phenogenetic variants. With the use of the Méhes Scale, our research group has been investigating the role of abnormal neurodevelopment in different neuropsychiatric and neurologic disorders since 1997. 25 years into our research, in this review we summarize the results of our 18 research articles on MPAs in different diseases. We have found an increased number of MPAs, especially in the head and mouth region, in patients with schizophrenia, bipolar disorder, Tourette syndrome, autism and many epilepsy syndromes, fortifying the role of abnormal neurodevelopment in these diseases. Moreover, an increased number of MPAs was detected among the first-degree relatives of patients with schizophrenia and bipolar I disorder, supporting the hypothesis about MPAs being endophenotypic trait markers.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1479156/fullminor physical anomaliesMéhes Scaleneurodevelopmental disordersschizophreniaepilepsy |
| spellingShingle | Dalma Tényi Györgyi Csábi József Janszky Róbert Herold Tamás Tényi 25 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphology Frontiers in Psychiatry minor physical anomalies Méhes Scale neurodevelopmental disorders schizophrenia epilepsy |
| title | 25 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphology |
| title_full | 25 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphology |
| title_fullStr | 25 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphology |
| title_full_unstemmed | 25 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphology |
| title_short | 25 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphology |
| title_sort | 25 years into research with the mehes scale a comprehensive scale of modern dysmorphology |
| topic | minor physical anomalies Méhes Scale neurodevelopmental disorders schizophrenia epilepsy |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1479156/full |
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