Intraoperative cerebral perfusion monitoring with ultrafast power doppler imaging
Abstract Brain perfusion monitoring during cerebrovascular surgery is highly desirable; however, this technology is not yet available to surgeons. Our center has developed and implemented a dedicated ultrafast power Doppler imaging (UPDI) sequence along with a novel postprocessing analysis. This met...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-04338-0 |
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| author | Hamid Reza Niknejad Yizhou Huang Anna Maria Auricchio Albert van der Zwan Massimo Mischi |
| author_facet | Hamid Reza Niknejad Yizhou Huang Anna Maria Auricchio Albert van der Zwan Massimo Mischi |
| author_sort | Hamid Reza Niknejad |
| collection | DOAJ |
| description | Abstract Brain perfusion monitoring during cerebrovascular surgery is highly desirable; however, this technology is not yet available to surgeons. Our center has developed and implemented a dedicated ultrafast power Doppler imaging (UPDI) sequence along with a novel postprocessing analysis. This method enables intraoperative, real-time (1 Hz) detection of changes in cerebral blood volume (CBV) at high spatial resolution (100 μm). We performed continuous UPDI acquisitions in 10 patients undergoing surgery for intracranial aneurysm clipping, AVM resection, or cerebrovascular bypass surgery. When temporary clipping was required during surgery, we recorded perfusion in the parenchyma within the vascular territory of the affected artery. Recordings began with a 30-second baseline and continued for up to 60 s after clip release. The UPDI sequence successfully demonstrated cerebral perfusion up to the level of the penetrating arterioles. The time-series data captured vascular phenomena such as ischemia, collateral recruitment, and hyperperfusion in both the cortex and white matter following the placement and removal of temporary clips. UPDI shows promise as a tool for continuous CBV monitoring during (cerebrovascular) surgery, as it enables quantitative vascular monitoring of the parenchyma. |
| format | Article |
| id | doaj-art-716ecc54b4cc4f79ba84ecabdecd1eec |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-716ecc54b4cc4f79ba84ecabdecd1eec2025-08-20T03:37:22ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-04338-0Intraoperative cerebral perfusion monitoring with ultrafast power doppler imagingHamid Reza Niknejad0Yizhou Huang1Anna Maria Auricchio2Albert van der Zwan3Massimo Mischi4Department of Neurosurgery, University Medical Center UtrechtSignal Processing Systems Unit, Eindhoven University of TechnologyDepartment of Neurosurgery, University Medical Center UtrechtDepartment of Neurosurgery, University Medical Center UtrechtSignal Processing Systems Unit, Eindhoven University of TechnologyAbstract Brain perfusion monitoring during cerebrovascular surgery is highly desirable; however, this technology is not yet available to surgeons. Our center has developed and implemented a dedicated ultrafast power Doppler imaging (UPDI) sequence along with a novel postprocessing analysis. This method enables intraoperative, real-time (1 Hz) detection of changes in cerebral blood volume (CBV) at high spatial resolution (100 μm). We performed continuous UPDI acquisitions in 10 patients undergoing surgery for intracranial aneurysm clipping, AVM resection, or cerebrovascular bypass surgery. When temporary clipping was required during surgery, we recorded perfusion in the parenchyma within the vascular territory of the affected artery. Recordings began with a 30-second baseline and continued for up to 60 s after clip release. The UPDI sequence successfully demonstrated cerebral perfusion up to the level of the penetrating arterioles. The time-series data captured vascular phenomena such as ischemia, collateral recruitment, and hyperperfusion in both the cortex and white matter following the placement and removal of temporary clips. UPDI shows promise as a tool for continuous CBV monitoring during (cerebrovascular) surgery, as it enables quantitative vascular monitoring of the parenchyma.https://doi.org/10.1038/s41598-025-04338-0Surgery related strokeUltrafast power Doppler imagingPerfusion |
| spellingShingle | Hamid Reza Niknejad Yizhou Huang Anna Maria Auricchio Albert van der Zwan Massimo Mischi Intraoperative cerebral perfusion monitoring with ultrafast power doppler imaging Scientific Reports Surgery related stroke Ultrafast power Doppler imaging Perfusion |
| title | Intraoperative cerebral perfusion monitoring with ultrafast power doppler imaging |
| title_full | Intraoperative cerebral perfusion monitoring with ultrafast power doppler imaging |
| title_fullStr | Intraoperative cerebral perfusion monitoring with ultrafast power doppler imaging |
| title_full_unstemmed | Intraoperative cerebral perfusion monitoring with ultrafast power doppler imaging |
| title_short | Intraoperative cerebral perfusion monitoring with ultrafast power doppler imaging |
| title_sort | intraoperative cerebral perfusion monitoring with ultrafast power doppler imaging |
| topic | Surgery related stroke Ultrafast power Doppler imaging Perfusion |
| url | https://doi.org/10.1038/s41598-025-04338-0 |
| work_keys_str_mv | AT hamidrezaniknejad intraoperativecerebralperfusionmonitoringwithultrafastpowerdopplerimaging AT yizhouhuang intraoperativecerebralperfusionmonitoringwithultrafastpowerdopplerimaging AT annamariaauricchio intraoperativecerebralperfusionmonitoringwithultrafastpowerdopplerimaging AT albertvanderzwan intraoperativecerebralperfusionmonitoringwithultrafastpowerdopplerimaging AT massimomischi intraoperativecerebralperfusionmonitoringwithultrafastpowerdopplerimaging |