STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) represent complex hematopoietic malignancies characterized by ineffective hematopoiesis and dysregulated myeloid differentiation. Recent research has underscored the critical role of aberrant STAT signaling pathways, particularly invol...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558625000168 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856831304302592 |
|---|---|
| author | Zoe King Sudhamsh Reddy Desai David A. Frank Aditi Shastri |
| author_facet | Zoe King Sudhamsh Reddy Desai David A. Frank Aditi Shastri |
| author_sort | Zoe King |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) represent complex hematopoietic malignancies characterized by ineffective hematopoiesis and dysregulated myeloid differentiation. Recent research has underscored the critical role of aberrant STAT signaling pathways, particularly involving STAT3 and STAT5, in the pathogenesis of these disorders. Aberrant activation of STAT proteins has been implicated as a mediator of oncogenesis in several malignancies. In this review, we discuss the role of STAT proteins in both regulated and dysregulated hematopoiesis, the consequences of dysregulation in acute myeloid leukemia and myelodysplastic syndromes, therapeutic strategies, and recent advancements in STAT-targeted therapy. By integrating findings from recent preclinical and clinical studies, this review provides insights into the evolving landscape of STAT-targeted therapies, highlighting the promise of these approaches in enhancing treatment efficacy and improving patient outcomes in high-risk hematologic malignancies. |
| format | Article |
| id | doaj-art-716e3ab1b5b64d4da05bd2e7e903279a |
| institution | Kabale University |
| issn | 1476-5586 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj-art-716e3ab1b5b64d4da05bd2e7e903279a2025-02-12T05:30:47ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862025-03-0161101137STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromesZoe King0Sudhamsh Reddy Desai1David A. Frank2Aditi Shastri3Department of Pediatric Hematology and Oncology, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; Corresponding author at: Division of Hematology, Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road NE, C4008, Atlanta, GA 30322, USA.Department of Oncology, Montefiore Medical Center & Albert Einstein College of Medicine, Bronx, NY, USA; Co-corresponding author at: Department of Oncology, Department of Developmental & Molecular Biology, Montefiore Medical Center & Albert Einstein College of Medicine, Chanin 302A, 1300 Morris Park Avenue, Bronx, NY 10461, USA.Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) represent complex hematopoietic malignancies characterized by ineffective hematopoiesis and dysregulated myeloid differentiation. Recent research has underscored the critical role of aberrant STAT signaling pathways, particularly involving STAT3 and STAT5, in the pathogenesis of these disorders. Aberrant activation of STAT proteins has been implicated as a mediator of oncogenesis in several malignancies. In this review, we discuss the role of STAT proteins in both regulated and dysregulated hematopoiesis, the consequences of dysregulation in acute myeloid leukemia and myelodysplastic syndromes, therapeutic strategies, and recent advancements in STAT-targeted therapy. By integrating findings from recent preclinical and clinical studies, this review provides insights into the evolving landscape of STAT-targeted therapies, highlighting the promise of these approaches in enhancing treatment efficacy and improving patient outcomes in high-risk hematologic malignancies.http://www.sciencedirect.com/science/article/pii/S1476558625000168Acute myeloid leukemiaMyelodysplastic syndromesTranscription factorsSTAT proteinsTherapeutic strategies |
| spellingShingle | Zoe King Sudhamsh Reddy Desai David A. Frank Aditi Shastri STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes Neoplasia: An International Journal for Oncology Research Acute myeloid leukemia Myelodysplastic syndromes Transcription factors STAT proteins Therapeutic strategies |
| title | STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes |
| title_full | STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes |
| title_fullStr | STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes |
| title_full_unstemmed | STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes |
| title_short | STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes |
| title_sort | stat signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes |
| topic | Acute myeloid leukemia Myelodysplastic syndromes Transcription factors STAT proteins Therapeutic strategies |
| url | http://www.sciencedirect.com/science/article/pii/S1476558625000168 |
| work_keys_str_mv | AT zoeking statsignalinginthepathogenesisandtherapyofacutemyeloidleukemiaandmyelodysplasticsyndromes AT sudhamshreddydesai statsignalinginthepathogenesisandtherapyofacutemyeloidleukemiaandmyelodysplasticsyndromes AT davidafrank statsignalinginthepathogenesisandtherapyofacutemyeloidleukemiaandmyelodysplasticsyndromes AT aditishastri statsignalinginthepathogenesisandtherapyofacutemyeloidleukemiaandmyelodysplasticsyndromes |