Leveraging strain competition to address antimicrobial resistance with microbiota therapies
The enteric microbiota is an established reservoir for multidrug-resistant organisms that present urgent clinical and public health threats. Observational data and small interventional studies suggest that microbiome interventions, such as fecal microbiota products and characterized live biotherapeu...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2488046 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850214984185806848 |
|---|---|
| author | Danielle Barrios Steed Dylan Koundakjian Anthony D. Harris Adriana E Rosato Konstantinos T Konstantinidis Michael H Woodworth |
| author_facet | Danielle Barrios Steed Dylan Koundakjian Anthony D. Harris Adriana E Rosato Konstantinos T Konstantinidis Michael H Woodworth |
| author_sort | Danielle Barrios Steed |
| collection | DOAJ |
| description | The enteric microbiota is an established reservoir for multidrug-resistant organisms that present urgent clinical and public health threats. Observational data and small interventional studies suggest that microbiome interventions, such as fecal microbiota products and characterized live biotherapeutic bacterial strains, could be an effective antibiotic-sparing prevention approach to address these threats. However, bacterial colonization is a complex ecological phenomenon that remains understudied in the context of the human gut. Antibiotic resistance is one among many adaptative strategies that impact long-term colonization. Here we review and synthesize evidence of how bacterial competition and differential fitness in the context of the gut present opportunities to improve mechanistic understanding of colonization resistance, therapeutic development, patient care, and ultimately public health. |
| format | Article |
| id | doaj-art-716d5e91a059409f80f58d3df921d55b |
| institution | OA Journals |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-716d5e91a059409f80f58d3df921d55b2025-08-20T02:08:45ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2488046Leveraging strain competition to address antimicrobial resistance with microbiota therapiesDanielle Barrios Steed0Dylan Koundakjian1Anthony D. Harris2Adriana E Rosato3Konstantinos T Konstantinidis4Michael H Woodworth5Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USADepartment of Medicine, Emory University Hospital, Atlanta, GA, USADepartment of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USACenter for Molecular Medicine, MaineHealth Institute for Research, Scarborough, ME, USASchool of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, USADepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USAThe enteric microbiota is an established reservoir for multidrug-resistant organisms that present urgent clinical and public health threats. Observational data and small interventional studies suggest that microbiome interventions, such as fecal microbiota products and characterized live biotherapeutic bacterial strains, could be an effective antibiotic-sparing prevention approach to address these threats. However, bacterial colonization is a complex ecological phenomenon that remains understudied in the context of the human gut. Antibiotic resistance is one among many adaptative strategies that impact long-term colonization. Here we review and synthesize evidence of how bacterial competition and differential fitness in the context of the gut present opportunities to improve mechanistic understanding of colonization resistance, therapeutic development, patient care, and ultimately public health.https://www.tandfonline.com/doi/10.1080/19490976.2025.2488046Antibiotic resistancefecal microbiota transplantationmicrobiotamicrobiomebacterial competitionquorum sensing |
| spellingShingle | Danielle Barrios Steed Dylan Koundakjian Anthony D. Harris Adriana E Rosato Konstantinos T Konstantinidis Michael H Woodworth Leveraging strain competition to address antimicrobial resistance with microbiota therapies Gut Microbes Antibiotic resistance fecal microbiota transplantation microbiota microbiome bacterial competition quorum sensing |
| title | Leveraging strain competition to address antimicrobial resistance with microbiota therapies |
| title_full | Leveraging strain competition to address antimicrobial resistance with microbiota therapies |
| title_fullStr | Leveraging strain competition to address antimicrobial resistance with microbiota therapies |
| title_full_unstemmed | Leveraging strain competition to address antimicrobial resistance with microbiota therapies |
| title_short | Leveraging strain competition to address antimicrobial resistance with microbiota therapies |
| title_sort | leveraging strain competition to address antimicrobial resistance with microbiota therapies |
| topic | Antibiotic resistance fecal microbiota transplantation microbiota microbiome bacterial competition quorum sensing |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2488046 |
| work_keys_str_mv | AT daniellebarriossteed leveragingstraincompetitiontoaddressantimicrobialresistancewithmicrobiotatherapies AT dylankoundakjian leveragingstraincompetitiontoaddressantimicrobialresistancewithmicrobiotatherapies AT anthonydharris leveragingstraincompetitiontoaddressantimicrobialresistancewithmicrobiotatherapies AT adrianaerosato leveragingstraincompetitiontoaddressantimicrobialresistancewithmicrobiotatherapies AT konstantinostkonstantinidis leveragingstraincompetitiontoaddressantimicrobialresistancewithmicrobiotatherapies AT michaelhwoodworth leveragingstraincompetitiontoaddressantimicrobialresistancewithmicrobiotatherapies |