Advanced Nanotechnology-Based Nucleic Acid Medicines
Nucleic acid medicines are a highly attractive modality that act in a sequence-specific manner on target molecules. To date, 21 such products have been approved by the Food and Drug Administration. However, the development of nucleic acid medicines continues to face various challenges, including tis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/11/1367 |
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| _version_ | 1850266844813852672 |
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| author | Noriko Miyamoto Mina Sakuragi Yukio Kitade |
| author_facet | Noriko Miyamoto Mina Sakuragi Yukio Kitade |
| author_sort | Noriko Miyamoto |
| collection | DOAJ |
| description | Nucleic acid medicines are a highly attractive modality that act in a sequence-specific manner on target molecules. To date, 21 such products have been approved by the Food and Drug Administration. However, the development of nucleic acid medicines continues to face various challenges, including tissue and cell targeting as well as intracellular delivery. Numerous research groups are addressing these issues by advancing the development of nucleic acid medicines through nanotechnology. In countries other than Japan (including Europe and the USA), >40 nanotechnology-based nucleic acid medicines have been tested in clinical trials, and 15 clinical trials are ongoing. In Japan, three phase I trials are ongoing, and future results are awaited. The review summarizes the latest research in the nanotechnology of nucleic acid medicines and statuses of clinical trials in Japan, with expectations of further evolutions. |
| format | Article |
| id | doaj-art-716d414a46f4491fb9f3ea76834af2ab |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-716d414a46f4491fb9f3ea76834af2ab2025-08-20T01:54:03ZengMDPI AGPharmaceutics1999-49232024-10-011611136710.3390/pharmaceutics16111367Advanced Nanotechnology-Based Nucleic Acid MedicinesNoriko Miyamoto0Mina Sakuragi1Yukio Kitade2Department of Applied Chemistry, Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota 470-0392, JapanDepartment of Nanoscience, Faculty of Engineering, Sojo University, 4-22-1, Ikeda, Nishi, Kumamoto 860-0082, JapanDepartment of Applied Chemistry, Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota 470-0392, JapanNucleic acid medicines are a highly attractive modality that act in a sequence-specific manner on target molecules. To date, 21 such products have been approved by the Food and Drug Administration. However, the development of nucleic acid medicines continues to face various challenges, including tissue and cell targeting as well as intracellular delivery. Numerous research groups are addressing these issues by advancing the development of nucleic acid medicines through nanotechnology. In countries other than Japan (including Europe and the USA), >40 nanotechnology-based nucleic acid medicines have been tested in clinical trials, and 15 clinical trials are ongoing. In Japan, three phase I trials are ongoing, and future results are awaited. The review summarizes the latest research in the nanotechnology of nucleic acid medicines and statuses of clinical trials in Japan, with expectations of further evolutions.https://www.mdpi.com/1999-4923/16/11/1367nucleic acid medicinesiRNAmiRNAmRNADNAASO |
| spellingShingle | Noriko Miyamoto Mina Sakuragi Yukio Kitade Advanced Nanotechnology-Based Nucleic Acid Medicines Pharmaceutics nucleic acid medicine siRNA miRNA mRNA DNA ASO |
| title | Advanced Nanotechnology-Based Nucleic Acid Medicines |
| title_full | Advanced Nanotechnology-Based Nucleic Acid Medicines |
| title_fullStr | Advanced Nanotechnology-Based Nucleic Acid Medicines |
| title_full_unstemmed | Advanced Nanotechnology-Based Nucleic Acid Medicines |
| title_short | Advanced Nanotechnology-Based Nucleic Acid Medicines |
| title_sort | advanced nanotechnology based nucleic acid medicines |
| topic | nucleic acid medicine siRNA miRNA mRNA DNA ASO |
| url | https://www.mdpi.com/1999-4923/16/11/1367 |
| work_keys_str_mv | AT norikomiyamoto advancednanotechnologybasednucleicacidmedicines AT minasakuragi advancednanotechnologybasednucleicacidmedicines AT yukiokitade advancednanotechnologybasednucleicacidmedicines |