β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease

β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease

Abstract Background β-synuclein (β-syn), mainly expressed in central nerve system, is one of the biomarkers in cerebrospinal fluid (CSF) and blood for synaptic damage, which has been reported to be elevated in CSF and blood of the patients of prion diseases (PrDs). Methods We analyzed 314 CSF sample...

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Bibliographic Details
Main Authors: Bing Xu, Kang Xiao, Xiaoxi Jia, Rundong Cao, Donglin Liang, Ruhan A, Weiwei Zhang, Chunjie Li, Liping Gao, Cao Chen, Qi Shi, Xiaoping Dong
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
β-synuclein
Cerebrospinal fluid
Human prion diseases
Online Access:https://doi.org/10.1186/s13195-025-01688-9
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