Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare Professionals and Consumers
ABSTRACT Integration of clinical pharmacogenomics (PGx) within routine cancer care is limited despite frequent use of medicines impacted by PGx, evidence for the benefits of PGx, and the availability of international PGx clinical guidelines. Our study objective was to develop survey tools to assess...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Clinical and Translational Science |
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| Online Access: | https://doi.org/10.1111/cts.70144 |
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| author | Marliese Alexander Chiao Xin Lim Senthil Lingaratnam Sarah Glewis Joanne Wickens Abbey Hird Zi Yue Chen Alistair Bozkurt Amit Khot David Routledge Sam Harris Craig Underhill Ashley Whitechurch Lydia Leong Marcus Pergolini Gail Rowan Monnette Samo Chloe Georgiou Peter Savas Jenny Devine Alysia Kepert Safeera Y. Hussainy |
| author_facet | Marliese Alexander Chiao Xin Lim Senthil Lingaratnam Sarah Glewis Joanne Wickens Abbey Hird Zi Yue Chen Alistair Bozkurt Amit Khot David Routledge Sam Harris Craig Underhill Ashley Whitechurch Lydia Leong Marcus Pergolini Gail Rowan Monnette Samo Chloe Georgiou Peter Savas Jenny Devine Alysia Kepert Safeera Y. Hussainy |
| author_sort | Marliese Alexander |
| collection | DOAJ |
| description | ABSTRACT Integration of clinical pharmacogenomics (PGx) within routine cancer care is limited despite frequent use of medicines impacted by PGx, evidence for the benefits of PGx, and the availability of international PGx clinical guidelines. Our study objective was to develop survey tools to assess PGx knowledge, attitudes, practices, perceptions, and education needs among (a) doctors, nurses, and pharmacists involved in cancer care (healthcare professionals, HCPs) and (b) adults who have received cancer treatment or their carers (consumers), with the view to informing implementation strategies for PGx in solid and hematologic cancers. Survey tools were developed in a three‐phase (ph) mixed‐methods approach. Content was informed by systematic literature review findings and framed by determinants of behavior as informed by the Theoretical Domains Framework (ph‐1). Refinement occurred through four separate priority partnership meetings (ph‐2). Meetings focused on clinical PGx practices within select cancer streams, and consumers' knowledge, attitudes, and preferences for PGx testing. Content/face validity and health literacy (Flesch Kincaid Grade Level) assessments informed final refinements (ph‐3). Separate HCP and consumer survey tools were developed with six common sections: (1) introduction; (2) demographics; (3) experience; (4) knowledge, attitudes, practices and perceptions; (5) education; and (6) vignettes. Content and face validity were rated highly with acceptable health literacy assessments for questions within the consumer survey (median grade level 6; range 1–8). The developed survey tools will be used to generate evidence to inform local implementation strategies for PGx in cancer and promote broader integration of pharmacogenomics in routine clinical care. |
| format | Article |
| id | doaj-art-716b836d7ab54329a100b1c1fc7a581c |
| institution | OA Journals |
| issn | 1752-8054 1752-8062 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Science |
| spelling | doaj-art-716b836d7ab54329a100b1c1fc7a581c2025-08-20T02:10:38ZengWileyClinical and Translational Science1752-80541752-80622025-03-01183n/an/a10.1111/cts.70144Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare Professionals and ConsumersMarliese Alexander0Chiao Xin Lim1Senthil Lingaratnam2Sarah Glewis3Joanne Wickens4Abbey Hird5Zi Yue Chen6Alistair Bozkurt7Amit Khot8David Routledge9Sam Harris10Craig Underhill11Ashley Whitechurch12Lydia Leong13Marcus Pergolini14Gail Rowan15Monnette Samo16Chloe Georgiou17Peter Savas18Jenny Devine19Alysia Kepert20Safeera Y. Hussainy21Pharmacy Department Peter MacCallum Cancer Centre Melbourne Victoria AustraliaPharmacy, School of Health and Biomedical Sciences RMIT University Bundoora Victoria AustraliaPharmacy Department Peter MacCallum Cancer Centre Melbourne Victoria AustraliaPharmacy Department Peter MacCallum Cancer Centre Melbourne Victoria AustraliaPharmacy, School of Health and Biomedical Sciences RMIT University Bundoora Victoria AustraliaPharmacy, School of Health and Biomedical Sciences RMIT University Bundoora Victoria AustraliaPharmacy, School of Health and Biomedical Sciences RMIT University Bundoora Victoria AustraliaPharmacy, School of Health and Biomedical Sciences RMIT University Bundoora Victoria AustraliaSir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Victoria AustraliaSir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Victoria AustraliaBendigo Cancer Centre Bendigo Health Bendigo Victoria AustraliaBorder Medical Oncology Research Unit Albury Wodonga Regional Cancer Centre Albury New South Wales AustraliaClinical Haematology Department Peter MacCallum Cancer Centre and Royal Melbourne Hospital Melbourne Victoria AustraliaPharmacy Department Peter MacCallum Cancer Centre Melbourne Victoria AustraliaPharmacy Department Peter MacCallum Cancer Centre Melbourne Victoria AustraliaPharmacy Department Peter MacCallum Cancer Centre Melbourne Victoria AustraliaPharmacy Department Peter MacCallum Cancer Centre Melbourne Victoria AustraliaBendigo Cancer Centre Bendigo Health Bendigo Victoria AustraliaSir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Victoria AustraliaAlcohol and Other Drugs Committee, The Royal Australian College of General Practitioners Melbourne Victoria AustraliaConsumer Representative Peter MacCallum Cancer Centre Melbourne Victoria AustraliaPharmacy Department Peter MacCallum Cancer Centre Melbourne Victoria AustraliaABSTRACT Integration of clinical pharmacogenomics (PGx) within routine cancer care is limited despite frequent use of medicines impacted by PGx, evidence for the benefits of PGx, and the availability of international PGx clinical guidelines. Our study objective was to develop survey tools to assess PGx knowledge, attitudes, practices, perceptions, and education needs among (a) doctors, nurses, and pharmacists involved in cancer care (healthcare professionals, HCPs) and (b) adults who have received cancer treatment or their carers (consumers), with the view to informing implementation strategies for PGx in solid and hematologic cancers. Survey tools were developed in a three‐phase (ph) mixed‐methods approach. Content was informed by systematic literature review findings and framed by determinants of behavior as informed by the Theoretical Domains Framework (ph‐1). Refinement occurred through four separate priority partnership meetings (ph‐2). Meetings focused on clinical PGx practices within select cancer streams, and consumers' knowledge, attitudes, and preferences for PGx testing. Content/face validity and health literacy (Flesch Kincaid Grade Level) assessments informed final refinements (ph‐3). Separate HCP and consumer survey tools were developed with six common sections: (1) introduction; (2) demographics; (3) experience; (4) knowledge, attitudes, practices and perceptions; (5) education; and (6) vignettes. Content and face validity were rated highly with acceptable health literacy assessments for questions within the consumer survey (median grade level 6; range 1–8). The developed survey tools will be used to generate evidence to inform local implementation strategies for PGx in cancer and promote broader integration of pharmacogenomics in routine clinical care.https://doi.org/10.1111/cts.70144cancerconsumershealth professionalspharmacogenomicssurvey |
| spellingShingle | Marliese Alexander Chiao Xin Lim Senthil Lingaratnam Sarah Glewis Joanne Wickens Abbey Hird Zi Yue Chen Alistair Bozkurt Amit Khot David Routledge Sam Harris Craig Underhill Ashley Whitechurch Lydia Leong Marcus Pergolini Gail Rowan Monnette Samo Chloe Georgiou Peter Savas Jenny Devine Alysia Kepert Safeera Y. Hussainy Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare Professionals and Consumers Clinical and Translational Science cancer consumers health professionals pharmacogenomics survey |
| title | Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare Professionals and Consumers |
| title_full | Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare Professionals and Consumers |
| title_fullStr | Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare Professionals and Consumers |
| title_full_unstemmed | Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare Professionals and Consumers |
| title_short | Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare Professionals and Consumers |
| title_sort | informing implementation strategies for pharmacogenomics in cancer development of survey tools for healthcare professionals and consumers |
| topic | cancer consumers health professionals pharmacogenomics survey |
| url | https://doi.org/10.1111/cts.70144 |
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