Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis.
Despite the importance of Helicobacter pylori infection and portal hypertension (PH)-associated gastrointestinal (GI) diseases, such as esophageal varices and portal hypertensive gastropathy (PHG), the impact of H. pylori infection on PH-related GI complications has not yet been elucidated. This met...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261448&type=printable |
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| author | Yu Kyung Jun Ji Won Kim Byeong Gwan Kim Kook Lae Lee Yong Jin Jung Won Kim Hyun Sun Park Dong Hyeon Lee Seong-Joon Koh |
| author_facet | Yu Kyung Jun Ji Won Kim Byeong Gwan Kim Kook Lae Lee Yong Jin Jung Won Kim Hyun Sun Park Dong Hyeon Lee Seong-Joon Koh |
| author_sort | Yu Kyung Jun |
| collection | DOAJ |
| description | Despite the importance of Helicobacter pylori infection and portal hypertension (PH)-associated gastrointestinal (GI) diseases, such as esophageal varices and portal hypertensive gastropathy (PHG), the impact of H. pylori infection on PH-related GI complications has not yet been elucidated. This meta-analysis investigated the association between H. pylori infection and the risk of PH-related GI complications. An electronic search for original articles published before May 2020 was performed using PubMed, EMBASE, and the Cochrane Library. Independent reviewers conducted the article screening and data extraction. We used the generic inverse variance method for the meta-analysis, and Begg's rank correlation test and Egger's regression test to assess publication bias. A total of 1,148 cases of H. pylori infection and 1,231 uninfected controls were included from 13 studies. H. pylori infection had no significant association with esophageal varices [relative risk (RR) = 0.96, 95% confidence interval (CI) = 0.87-1.06 for all selected studies; RR = 0.95, 95% CI = 0.84-1.07 for cohort studies; odds ratio (OR) = 0.96, 95% CI = 0.60-1.54 for case-control studies]. Although H. pylori infection was significantly associated with PHG in case-control studies [OR = 1.86, 95% CI = 1.17-2.96], no significant differences were found in the cohort studies [RR = 0.98, 95% CI = 0.91-1.05] or all studies combined [RR = 1.18, 95% CI = 0.93-1.52]. In conclusion, H. pylori infection was not associated with the risk of PH-related GI complications. Clinicians should carefully treat cirrhotic patients with PH-related GI complications, regardless of H. pylori infection. |
| format | Article |
| id | doaj-art-716874ad6599434a868514e0d77741e6 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-716874ad6599434a868514e0d77741e62025-01-24T05:31:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01171e026144810.1371/journal.pone.0261448Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis.Yu Kyung JunJi Won KimByeong Gwan KimKook Lae LeeYong Jin JungWon KimHyun Sun ParkDong Hyeon LeeSeong-Joon KohDespite the importance of Helicobacter pylori infection and portal hypertension (PH)-associated gastrointestinal (GI) diseases, such as esophageal varices and portal hypertensive gastropathy (PHG), the impact of H. pylori infection on PH-related GI complications has not yet been elucidated. This meta-analysis investigated the association between H. pylori infection and the risk of PH-related GI complications. An electronic search for original articles published before May 2020 was performed using PubMed, EMBASE, and the Cochrane Library. Independent reviewers conducted the article screening and data extraction. We used the generic inverse variance method for the meta-analysis, and Begg's rank correlation test and Egger's regression test to assess publication bias. A total of 1,148 cases of H. pylori infection and 1,231 uninfected controls were included from 13 studies. H. pylori infection had no significant association with esophageal varices [relative risk (RR) = 0.96, 95% confidence interval (CI) = 0.87-1.06 for all selected studies; RR = 0.95, 95% CI = 0.84-1.07 for cohort studies; odds ratio (OR) = 0.96, 95% CI = 0.60-1.54 for case-control studies]. Although H. pylori infection was significantly associated with PHG in case-control studies [OR = 1.86, 95% CI = 1.17-2.96], no significant differences were found in the cohort studies [RR = 0.98, 95% CI = 0.91-1.05] or all studies combined [RR = 1.18, 95% CI = 0.93-1.52]. In conclusion, H. pylori infection was not associated with the risk of PH-related GI complications. Clinicians should carefully treat cirrhotic patients with PH-related GI complications, regardless of H. pylori infection.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261448&type=printable |
| spellingShingle | Yu Kyung Jun Ji Won Kim Byeong Gwan Kim Kook Lae Lee Yong Jin Jung Won Kim Hyun Sun Park Dong Hyeon Lee Seong-Joon Koh Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis. PLoS ONE |
| title | Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis. |
| title_full | Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis. |
| title_fullStr | Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis. |
| title_full_unstemmed | Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis. |
| title_short | Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis. |
| title_sort | helicobacter pylori infection is not associated with portal hypertension related gastrointestinal complications a meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261448&type=printable |
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