ReCLAIM-2: A Randomized Phase II Clinical Trial Evaluating Elamipretide in Age-related Macular Degeneration, Geographic Atrophy Growth, Visual Function, and Ellipsoid Zone Preservation

ReCLAIM-2: A Randomized Phase II Clinical Trial Evaluating Elamipretide in Age-related Macular Degeneration, Geographic Atrophy Growth, Visual Function, and Ellipsoid Zone Preservation

Objective: This study evaluated the safety and efficacy of elamipretide in dry age-related macular degeneration (AMD) with noncentral geographic atrophy (GA). Design: ReCLAIM-2 was a prospective, phase II, randomized, placebo-controlled, double-masked, multicenter trial (NCT03891875). Subjects: Pati...

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Main Authors: Justis P. Ehlers, MD, Allen Hu, MD, David Boyer, MD, Scott W. Cousins, MD, Nadia K. Waheed, MD, Philip J. Rosenfeld, MD, PhD, David Brown, MD, Peter K. Kaiser, MD, Anthony Abbruscato, PharmD, Gui Gao, PhD, Jeffrey Heier, MD, Prema Abraham, Christopher Devine, Anita Schadlu, George Novalis, Derek Y. Kunimoto, John Parchue, Suk Jin Moon, Zachary Segal, Dennis Marcus, Paul Hahn, Eric Suan, Michael Lee, Victor Gonzalez, Michael A. Samuel, Sunil Patel, Patrick Williams, Brian B. Berger, Henry Kwong, Dante Pieramici, Eric W. Schneider, Yevgeniy Shildkrot, Mathew T. Witmer, Nathan Steinle, Carmelina Gordon, Daniel Learned, Patrick Higgins, Guruprasad Pattar, Vijay Khetpal, Robin Ross, Mark R. Barakat, Sun Young Lee Sjatkowski, David Lally, Troy Becker
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ophthalmology Science
Subjects:
Age-related macular degeneration
Elamipretide
Ellipsoid zone
Geographic atrophy
Visual acuity
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914524001647
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