Ursodeoxycholic acid in complex treatment of metabolic syndrome
Aim of investigation. Evaluation of effect of ursodeoxycholic acid (Ursosan) on levels of immunoreactive insulin, leptin, clinical and biochemical tests in metabolic syndrome.Material and methods. The group of patients with metabolic syndrome (66 patients, aged 38 to 67 years) received Ursosan withi...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2012-02-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1266 |
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| author | O. A. Tanchenko S. V. Naryshkina O. N. Sivyakova |
| author_facet | O. A. Tanchenko S. V. Naryshkina O. N. Sivyakova |
| author_sort | O. A. Tanchenko |
| collection | DOAJ |
| description | Aim of investigation. Evaluation of effect of ursodeoxycholic acid (Ursosan) on levels of immunoreactive insulin, leptin, clinical and biochemical tests in metabolic syndrome.Material and methods. The group of patients with metabolic syndrome (66 patients, aged 38 to 67 years) received Ursosan within complex treatment. Control group included 21 patients. Dynamics of immunoreactive insulin, leptin, lipid spectrum was determined by immunoenzyme test.Results. Significant decrease of transaminase, gamma-glutamyltranspeptidase, alkaline phosphatase activity, total cholesterol, triglyceride level, atherogenicity index was found in patients receiving Ursosan 15 mg/kg of body weight for 8 wks within complex treatment with trend for decrease of leptin and hyperinsulinemia level.Conclusions. Addition of Ursosan to complex treatment of patients with metabolic syndrome results in significant decrease of immunoreactive insulin, atherogenous fractions of lipids parameters with the tendency for decrease of leptin that playing the leading role in development and progression of metabolic syndrome. |
| format | Article |
| id | doaj-art-715d9975e4cb4b048f0d0c807cab506c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2012-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-715d9975e4cb4b048f0d0c807cab506c2025-02-10T16:14:31ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732012-02-012218286846Ursodeoxycholic acid in complex treatment of metabolic syndromeO. A. Tanchenko0S. V. Naryshkina1O. N. Sivyakova2Амурская государственная медицинская академияАмурская государственная медицинская академияАмурская государственная медицинская академияAim of investigation. Evaluation of effect of ursodeoxycholic acid (Ursosan) on levels of immunoreactive insulin, leptin, clinical and biochemical tests in metabolic syndrome.Material and methods. The group of patients with metabolic syndrome (66 patients, aged 38 to 67 years) received Ursosan within complex treatment. Control group included 21 patients. Dynamics of immunoreactive insulin, leptin, lipid spectrum was determined by immunoenzyme test.Results. Significant decrease of transaminase, gamma-glutamyltranspeptidase, alkaline phosphatase activity, total cholesterol, triglyceride level, atherogenicity index was found in patients receiving Ursosan 15 mg/kg of body weight for 8 wks within complex treatment with trend for decrease of leptin and hyperinsulinemia level.Conclusions. Addition of Ursosan to complex treatment of patients with metabolic syndrome results in significant decrease of immunoreactive insulin, atherogenous fractions of lipids parameters with the tendency for decrease of leptin that playing the leading role in development and progression of metabolic syndrome.https://www.gastro-j.ru/jour/article/view/1266metabolic syndromeursosanimmunoreactive insulinleptingamma-glutamyltranspeptidasetriglycerides |
| spellingShingle | O. A. Tanchenko S. V. Naryshkina O. N. Sivyakova Ursodeoxycholic acid in complex treatment of metabolic syndrome Российский журнал гастроэнтерологии, гепатологии, колопроктологии metabolic syndrome ursosan immunoreactive insulin leptin gamma-glutamyltranspeptidase triglycerides |
| title | Ursodeoxycholic acid in complex treatment of metabolic syndrome |
| title_full | Ursodeoxycholic acid in complex treatment of metabolic syndrome |
| title_fullStr | Ursodeoxycholic acid in complex treatment of metabolic syndrome |
| title_full_unstemmed | Ursodeoxycholic acid in complex treatment of metabolic syndrome |
| title_short | Ursodeoxycholic acid in complex treatment of metabolic syndrome |
| title_sort | ursodeoxycholic acid in complex treatment of metabolic syndrome |
| topic | metabolic syndrome ursosan immunoreactive insulin leptin gamma-glutamyltranspeptidase triglycerides |
| url | https://www.gastro-j.ru/jour/article/view/1266 |
| work_keys_str_mv | AT oatanchenko ursodeoxycholicacidincomplextreatmentofmetabolicsyndrome AT svnaryshkina ursodeoxycholicacidincomplextreatmentofmetabolicsyndrome AT onsivyakova ursodeoxycholicacidincomplextreatmentofmetabolicsyndrome |