Dual associations of gut and oral microbial networks with kidney transplantation
ABSTRACT Gut and oral microbiomes play an essential role in the occurrence and development of kidney disease, but their changes after kidney transplantation in patients with end-stage renal disease and their relationships with host health remain unclear. Through shotgun metagenomic sequencing of fec...
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| Language: | English |
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American Society for Microbiology
2025-08-01
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| Series: | mSystems |
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| Online Access: | https://journals.asm.org/doi/10.1128/msystems.00252-25 |
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| author | Siming Qu Yuzheng Gu Xiaoxue Hou Min Wei Mengmeng Wang Yuya Su Yinglei Miao Jinlong Yang Yang Sun Zhong Zeng |
| author_facet | Siming Qu Yuzheng Gu Xiaoxue Hou Min Wei Mengmeng Wang Yuya Su Yinglei Miao Jinlong Yang Yang Sun Zhong Zeng |
| author_sort | Siming Qu |
| collection | DOAJ |
| description | ABSTRACT Gut and oral microbiomes play an essential role in the occurrence and development of kidney disease, but their changes after kidney transplantation in patients with end-stage renal disease and their relationships with host health remain unclear. Through shotgun metagenomic sequencing of fecal and saliva samples, we found that for both gut and oral microbiome, the initial loss of species diversity after kidney transplantation led to a reduction in network nodes and interactions, but strengthened the connections among the remaining species, which started to get a recovery approximately 7–14 days later. Different network modules tended to exhibit unique functions and showed different responses to transplantation. These network changes were significantly correlated with clinical indicators, especially with estimated glomerular filtration rate, suggesting that microbial networks contributed to regulating kidney function and host health from dual dimensions. Our study provides novel insights into associating microbiomes with patient recovery after kidney transplantation and offers new diagnostic strategies.IMPORTANCEUnderstanding the dynamics of gut and oral microbiomes after kidney transplantation is crucial for improving post-transplant outcomes and managing potential complications. Through shotgun metagenomic sequencing of fecal and saliva samples from patients following kidney transplantation, our study emphasizes that, in addition to focusing on the various microbial species themselves, the topological properties of gut and oral microbial networks are also critically important for kidney function. We aim to explore the relationship between host health and the oral and gut microbiomes following kidney transplantation from an ecological perspective and extend to other diseases to advance the study of the microbiome and its clinical impact. |
| format | Article |
| id | doaj-art-715d97d3fdb44fb1a0be96aff5b93d0b |
| institution | Kabale University |
| issn | 2379-5077 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSystems |
| spelling | doaj-art-715d97d3fdb44fb1a0be96aff5b93d0b2025-08-20T03:47:16ZengAmerican Society for MicrobiologymSystems2379-50772025-08-0110810.1128/msystems.00252-25Dual associations of gut and oral microbial networks with kidney transplantationSiming Qu0Yuzheng Gu1Xiaoxue Hou2Min Wei3Mengmeng Wang4Yuya Su5Yinglei Miao6Jinlong Yang7Yang Sun8Zhong Zeng9Department of Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaCollege of Grassland Agriculture, Northwest A&F University, Yangling, ChinaCollege of Agriculture, South China Agricultural University, Guangzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaCollege of Life Sciences, University of the Chinese Academy of Sciences, Beijing, Beijing, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaCollege of Forensic Sciences, Xi'an Jiaotong University, Xi'An, Shaanxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaABSTRACT Gut and oral microbiomes play an essential role in the occurrence and development of kidney disease, but their changes after kidney transplantation in patients with end-stage renal disease and their relationships with host health remain unclear. Through shotgun metagenomic sequencing of fecal and saliva samples, we found that for both gut and oral microbiome, the initial loss of species diversity after kidney transplantation led to a reduction in network nodes and interactions, but strengthened the connections among the remaining species, which started to get a recovery approximately 7–14 days later. Different network modules tended to exhibit unique functions and showed different responses to transplantation. These network changes were significantly correlated with clinical indicators, especially with estimated glomerular filtration rate, suggesting that microbial networks contributed to regulating kidney function and host health from dual dimensions. Our study provides novel insights into associating microbiomes with patient recovery after kidney transplantation and offers new diagnostic strategies.IMPORTANCEUnderstanding the dynamics of gut and oral microbiomes after kidney transplantation is crucial for improving post-transplant outcomes and managing potential complications. Through shotgun metagenomic sequencing of fecal and saliva samples from patients following kidney transplantation, our study emphasizes that, in addition to focusing on the various microbial species themselves, the topological properties of gut and oral microbial networks are also critically important for kidney function. We aim to explore the relationship between host health and the oral and gut microbiomes following kidney transplantation from an ecological perspective and extend to other diseases to advance the study of the microbiome and its clinical impact.https://journals.asm.org/doi/10.1128/msystems.00252-25kidney transplantationgut microbiomeoral microbiomemicrobial co-occurrence networksshotgun metagenomic sequencing |
| spellingShingle | Siming Qu Yuzheng Gu Xiaoxue Hou Min Wei Mengmeng Wang Yuya Su Yinglei Miao Jinlong Yang Yang Sun Zhong Zeng Dual associations of gut and oral microbial networks with kidney transplantation mSystems kidney transplantation gut microbiome oral microbiome microbial co-occurrence networks shotgun metagenomic sequencing |
| title | Dual associations of gut and oral microbial networks with kidney transplantation |
| title_full | Dual associations of gut and oral microbial networks with kidney transplantation |
| title_fullStr | Dual associations of gut and oral microbial networks with kidney transplantation |
| title_full_unstemmed | Dual associations of gut and oral microbial networks with kidney transplantation |
| title_short | Dual associations of gut and oral microbial networks with kidney transplantation |
| title_sort | dual associations of gut and oral microbial networks with kidney transplantation |
| topic | kidney transplantation gut microbiome oral microbiome microbial co-occurrence networks shotgun metagenomic sequencing |
| url | https://journals.asm.org/doi/10.1128/msystems.00252-25 |
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