BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROL
The authors have carried on a prospective open comparative study within the parallel groups to assess the dynamics of the markers of the inflammation among the patients with various degree of bronchial asthma severity against the background of the anti-inflammatory therapy and define the role of nit...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Union of pediatricians of Russia
2006-12-01
|
| Series: | Педиатрическая фармакология |
| Online Access: | https://www.pedpharma.ru/jour/article/view/590 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849685707243651072 |
|---|---|
| author | L.M. Ogorodova D.V. Kozyritskaya I.A. Deev Yu.A. Petrovskaya A.V. Ekimovskikh |
| author_facet | L.M. Ogorodova D.V. Kozyritskaya I.A. Deev Yu.A. Petrovskaya A.V. Ekimovskikh |
| author_sort | L.M. Ogorodova |
| collection | DOAJ |
| description | The authors have carried on a prospective open comparative study within the parallel groups to assess the dynamics of the markers of the inflammation among the patients with various degree of bronchial asthma severity against the background of the anti-inflammatory therapy and define the role of nitrogen oxide in respiratory condensate as a biomarker during the bronchial asthma. All the patients (n = 54) have undergone determination of the bronchial hypere activity level, nitrite level in respiratory condensate, relative number of eosinophiles of nasal secretion against the background of the anti-inflammatory basic therapy application adequate to the degree of bronchial asthma severity. the researchers have revealed that application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity led to achievement of the criteria for the control over bronchial asthma symptoms among the majority of patients already towards the end of the 12th week. Nevertheless, the accurate reduction of biomarkers of allergic inflammation was registered only in the end of the treatment period (24 weeks). Thus, the application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity is necessary within no less than 24 weeks. It helps to achieve the control over symptoms of the disease, as well as it is accompanied by the accurate reduction of biomarkers of atopic inflammation, and there? Fore, it leads to the activity reduction of the respiratory tract inflammation. Biomarkers may be used not only for the purpose to assess the inflammation of the respiratory passages, but also as a marker for the asthma therapy effectiveness, which can allow optimizing the bronchial asthma therapy among children.Key words: bronchial asthma, children, atopic inflammation, bio-markers, nitrogen oxide, eosinophiles, bronchial hyperreactivity. |
| format | Article |
| id | doaj-art-715b190f4c314b559c47dc6925ed77b3 |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2006-12-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-715b190f4c314b559c47dc6925ed77b32025-08-20T03:23:02ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892006-12-0135913586BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROLL.M. Ogorodova0D.V. Kozyritskaya1I.A. Deev2Yu.A. Petrovskaya3A.V. Ekimovskikh4Siberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskThe authors have carried on a prospective open comparative study within the parallel groups to assess the dynamics of the markers of the inflammation among the patients with various degree of bronchial asthma severity against the background of the anti-inflammatory therapy and define the role of nitrogen oxide in respiratory condensate as a biomarker during the bronchial asthma. All the patients (n = 54) have undergone determination of the bronchial hypere activity level, nitrite level in respiratory condensate, relative number of eosinophiles of nasal secretion against the background of the anti-inflammatory basic therapy application adequate to the degree of bronchial asthma severity. the researchers have revealed that application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity led to achievement of the criteria for the control over bronchial asthma symptoms among the majority of patients already towards the end of the 12th week. Nevertheless, the accurate reduction of biomarkers of allergic inflammation was registered only in the end of the treatment period (24 weeks). Thus, the application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity is necessary within no less than 24 weeks. It helps to achieve the control over symptoms of the disease, as well as it is accompanied by the accurate reduction of biomarkers of atopic inflammation, and there? Fore, it leads to the activity reduction of the respiratory tract inflammation. Biomarkers may be used not only for the purpose to assess the inflammation of the respiratory passages, but also as a marker for the asthma therapy effectiveness, which can allow optimizing the bronchial asthma therapy among children.Key words: bronchial asthma, children, atopic inflammation, bio-markers, nitrogen oxide, eosinophiles, bronchial hyperreactivity.https://www.pedpharma.ru/jour/article/view/590 |
| spellingShingle | L.M. Ogorodova D.V. Kozyritskaya I.A. Deev Yu.A. Petrovskaya A.V. Ekimovskikh BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROL Педиатрическая фармакология |
| title | BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROL |
| title_full | BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROL |
| title_fullStr | BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROL |
| title_full_unstemmed | BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROL |
| title_short | BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROL |
| title_sort | biomarkers of the allergic inflammation as additional criteria for the asthma control |
| url | https://www.pedpharma.ru/jour/article/view/590 |
| work_keys_str_mv | AT lmogorodova biomarkersoftheallergicinflammationasadditionalcriteriafortheasthmacontrol AT dvkozyritskaya biomarkersoftheallergicinflammationasadditionalcriteriafortheasthmacontrol AT iadeev biomarkersoftheallergicinflammationasadditionalcriteriafortheasthmacontrol AT yuapetrovskaya biomarkersoftheallergicinflammationasadditionalcriteriafortheasthmacontrol AT avekimovskikh biomarkersoftheallergicinflammationasadditionalcriteriafortheasthmacontrol |