Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study
This study aimed to investigate the effects of physical multimorbidity on the trajectory of cognitive decline over 17 years and whether vary across wealth status. The study was conducted in 9035 respondents aged 50+ at baseline from nine waves (2002–2019) of the English Longitudinal Study of Aging....
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | Cambridge Prisms: Global Mental Health |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2054425124001419/type/journal_article |
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| author | Chen Chen Shan Zhang Ning Huang Mingyu Zhang JinXin Fu Jing Guo |
| author_facet | Chen Chen Shan Zhang Ning Huang Mingyu Zhang JinXin Fu Jing Guo |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | This study aimed to investigate the effects of physical multimorbidity on the trajectory of cognitive decline over 17 years and whether vary across wealth status. The study was conducted in 9035 respondents aged 50+ at baseline from nine waves (2002–2019) of the English Longitudinal Study of Aging. A latent class analysis was used to identify patterns of physical multimorbidity, and mixed multilevel models were performed to determine the association between physical multimorbidity and trajectories of cognitive decline. Joint analyses were conducted to further verify the influence of wealth status. Four patterns of physical multimorbidity were identified. Mixed multilevel models with quadratic terms of time and status/patterns indicated significant non-linear trajectories of multimorbidity on cognitive function. The magnitude of the association between complex multisystem patterns and cognitive decline increased the most as follow-up progressed. Individuals with high wealth and hypertension/diabetes patterns have significantly lower composite global cognitive z scores over time as compared with respiratory/osteoporosis patterns. Physical multimorbidity at baseline is associated with the trajectory of cognitive decline, and the magnitude of the association increased over time. The trend of cognitive decline differed in specific combinations of wealth status and physical multimorbidity. |
| format | Article |
| id | doaj-art-7158b7bd0e394b32884cff8c678a866f |
| institution | Kabale University |
| issn | 2054-4251 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Cambridge Prisms: Global Mental Health |
| spelling | doaj-art-7158b7bd0e394b32884cff8c678a866f2025-01-16T21:51:40ZengCambridge University PressCambridge Prisms: Global Mental Health2054-42512024-01-011110.1017/gmh.2024.141Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort studyChen Chen0Shan Zhang1Ning Huang2Mingyu Zhang3JinXin Fu4Jing Guo5https://orcid.org/0000-0001-8085-0117Department of Health Policy and Management, School of Public Health, Peking University, Beijing, ChinaDepartment of Health Policy and Management, School of Public Health, Peking University, Beijing, ChinaDepartment of Health Policy and Management, School of Public Health, Peking University, Beijing, ChinaDepartment of Health Policy and Management, School of Public Health, Peking University, Beijing, ChinaDepartment of Interventional Radiology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Health Policy and Management, School of Public Health, Peking University, Beijing, ChinaThis study aimed to investigate the effects of physical multimorbidity on the trajectory of cognitive decline over 17 years and whether vary across wealth status. The study was conducted in 9035 respondents aged 50+ at baseline from nine waves (2002–2019) of the English Longitudinal Study of Aging. A latent class analysis was used to identify patterns of physical multimorbidity, and mixed multilevel models were performed to determine the association between physical multimorbidity and trajectories of cognitive decline. Joint analyses were conducted to further verify the influence of wealth status. Four patterns of physical multimorbidity were identified. Mixed multilevel models with quadratic terms of time and status/patterns indicated significant non-linear trajectories of multimorbidity on cognitive function. The magnitude of the association between complex multisystem patterns and cognitive decline increased the most as follow-up progressed. Individuals with high wealth and hypertension/diabetes patterns have significantly lower composite global cognitive z scores over time as compared with respiratory/osteoporosis patterns. Physical multimorbidity at baseline is associated with the trajectory of cognitive decline, and the magnitude of the association increased over time. The trend of cognitive decline differed in specific combinations of wealth status and physical multimorbidity.https://www.cambridge.org/core/product/identifier/S2054425124001419/type/journal_articlecognitive declinephysical multimorbiditywealth statuspopulation-based study |
| spellingShingle | Chen Chen Shan Zhang Ning Huang Mingyu Zhang JinXin Fu Jing Guo Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study Cambridge Prisms: Global Mental Health cognitive decline physical multimorbidity wealth status population-based study |
| title | Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study |
| title_full | Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study |
| title_fullStr | Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study |
| title_full_unstemmed | Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study |
| title_short | Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study |
| title_sort | effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status a 17 year population based cohort study |
| topic | cognitive decline physical multimorbidity wealth status population-based study |
| url | https://www.cambridge.org/core/product/identifier/S2054425124001419/type/journal_article |
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