Anti-SARS-CoV-2 serology based on ancestral RBD antigens does not correlate with the presence of neutralizing antibodies against Omicron variants

Anti-SARS-CoV-2 serology based on ancestral RBD antigens does not correlate with the presence of neutralizing antibodies against Omicron variants

ABSTRACT Neutralizing antibody titers and binding antibody levels are considered correlates of protection against severe SARS-CoV-2 infection. The clinical utility of serology should be reevaluated in light of the emergence of escape variants, as commercial antibody-binding assays have not been adap...

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Bibliographic Details
Main Authors: Léa Dépéry, Isabelle Bally, Axelle Amen, Benjamin Némoz, Marlyse Buisson, Laurence Grossi, Aurélie Truffot, Raphaële Germi, Delphine Guilligay, Mélanie Veloso, Antoine Vilotitch, Olivier Epaulard, Patrice Morand, Winfried Weissenhorn, Pascal Poignard, Julien Lupo
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
serology
neutralizing antibodies
Omicron
COVID
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01568-24
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